Doctoral Degrees (Medical Microbiology)
Recent Submissions
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Molecular epidemiology of antibiotic resistant ESKAPE pathogens isolated from public sector hospitals in uMgungundlovu District, KwaZulu-Natal, South Africa.
(2017)Multi-drug resistant Enterococcus faecium, staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp termed ESKAPE pathogens are commonly implicated in ... -
Investigating schistosomiasis markers of inflammation and immune responses in school children on repeated mass drug administration in Bandanyenje, Zimbabwe.
(2017)Abstract available in PDF file. -
Microchemostat technologies for characterization of efflux pumps associated with multidrug resistance in mycobacterium tuberculosis.
(2016)Abstract available in PDF file. -
TylA has an essential virulence role in mycobacterium tuberculosis pathogenesis.
(2015)Mycobacterium tuberculosis (M.tb), the causative agent of the disease tuberculosis, is an ancient pathogen and a major cause of death worldwide. Although various virulence factors of M.tb have been identified, its pathogenesis ... -
Antibiotic resistance in mycobacterium tuberculosis : the role of genetic mutations in resistance conferring genes and efflux transporters.
(2016)Two decades after the World Health Organisation (WHO) declaration of tuberculosis (TB) as a global emergency, the disease remains a public health crisis of epic proportions. The emergence of drug resistant strains of ... -
Improving the efficacy of bacillus calmette guerin vaccine by concomitant inhibition of T regulatory and T helper 2 cells.
(2015)Tuberculosis (TB) remains a major threat to human population as currently Mycobacterium tuberculosis (MTB) infects nearly 33% of the global population. Annually, about one and a half million deaths are caused by tuberculosis ... -
Effectiveness of a monovalent human rotavirus vaccine among children of 5 years and under in KwaZulu-Natal.
(2016)Human rotavirus infection is the leading cause of gastroenteritis in infants and young children worldwide. In South Africa, gastroenteritis is a major cause of childhood morbidity and mortality in children less than 5 ... -
Fitness of multi-and extensively drug-resistant mycobacterium tuberculosis clinical strains.
(2015)The biological fitness of a pathogen is defined as its ability to reproduce, survive, cause disease and be transmitted. Drug-resistant M. tuberculosis isolates often exhibit reduced competitive ability against susceptible ... -
Genetic and microrna polymorphisms in young South African Indians with coronary artery disease.
(2015)The global burden of cardiovascular disease (CVD) is on the increase with coronary artery disease (CAD) estimated to become the leading cause of mortality worldwide by 2020. The age of onset of this chronic disorder is on ... -
The impact of sexually transmitted infections (STI) and genital tract inflammation on HIV-1 acquisition and rate of disease progression in subtype C infected women.
(2014)Introduction: Women carry more than half the burden of HIV disease globally and this burden is even higher in sub-Saharan Africa (SSA). Young women, in particular, are at disproportionate risk of HIV infection in South ... -
Immunopathogenesis of vulvo-vaginal candidiasis in human immunodeficiency virus infected women.
(2014)Vulvovaginal candidiasis (VVC) is an important cause of lower genital tract infections in women. There are currently numerous clinical observations linking increased cases of symptomatic VVC to the progression of HIV ... -
Susceptibility of Trichomonas vaginalis to metronidazole and other compounds.
(2015)Trichomonas vaginalis is the most common sexually transmitted infection caused by a single known organism worldwide; and has been associated with an increased risk of HIV acquisition and transmission. Despite its high ... -
The role of APOBEC3G in acute and early HIV-1 subtype C infection.
(2014)Introduction APOBEC3G and other related cellular cytosine deaminase family members have potent antiviral activity. In the absence of HIV-1 Vif, APOBEC3G mutates the viral DNA during viral reverse transcription. Our knowledge ... -
Host induced microevolution of ESX secretion systems of M. Tuberculosis.
(2013)The ESX family of genes (esxA-W) in Mycobacterium tuberculosis (Mtb) encodes 23 effector molecules influencing immunogenicity and pathogenicity. This study was aimed at identifying and evaluating variations in ESX sequence ... -
Development of novel reagents for tuberculosis detection.
(2013-10-24)Tuberculosis (TB) is one of the most prevalent infectious diseases worldwide and causes high morbidity and mortality, despite the widespread availability of effective antibiotics against most strains of Mycobacterium ... -
A pharmacokinetic study of rifabutin and its interaction with antiretrovirals in African patients with TB-HIV co-infection.
(2013-10-23)The management of HIV-associated tuberculosis (TB) is complicated by the pharmacokinetic interactions between rifampicin (RMP) and co-administered protease inhibitors (PIs) and non-nucleoside reverse transcriptase ...
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