• Retail pharmacy prescription medicines availability, prices, and affordability in Eswatini. 

  Shambira, Garikai. (2021)

  Background: The low availability of medicines in public health outlets coupled with unaffordable prices in the private sector can be a major barrier to medicines’ access. Patients in Eswatini may be forced to buy medicines ...

• Effects of Z-venusol and other pure compounds from medicinal plants on prostate, cervical and breast cancer cells. 

  Mathibe, Lehlohonolo John. (2017)

  Introduction According to recent World Health Organisation (WHO) estimates, cancer causes more deaths than coronary heart diseases globally (GLOBOCAN, 2012). While communicable diseases such as HIV/AIDS continue to ...

• Functional and molecular changes associated with intranasal buprenorphine in a healthy rodent model. 

  Xhakaza, Sanelisiwe Penelope. (2020)

  Opioid addiction is a spiralling global epidemic associated with intense drug craving and the compulsive use of opiate drugs such as heroin, oxycodone, oxymorphone amongst others. Buprenorphine (BUP), commercially available ...

• Molecular epidemiology of antibiotic-resistant Enterococcus spp. from farm-to-fork in intensive pig production in KwaZulu-Natal, South Africa. 

  Badul, Sasha. (2021)

  Background: Substantial antibiotic use and high population densities in intensive farming systems results in the emergence and spread of antibiotic-resistant commensals and pathogens. This study investigated the molecular ...

• Molecular epidemiology of carbapenem-resistant Enterobacterales colonization in an intensive care unit. 

  Madni, Osama. (2021)

  Background: Due to the high association with mortality and morbidity, carbapenem-resistant Enterobacterales (CRE) in general, and carbapenem-resistant Klebsiella pneumoniae, in particular, have been listed as high-priority ...

• Mechanistic insights and in silico studies on selected G protein-coupled receptors implicated in HIV and neurological disorders. 

  Appiah-Kubi, Patrick. (2021)

  G protein-coupled receptors (GPCRs) are the largest membrane protein receptor superfamily involved in a wide range of physiological processes. GPCRs form the major class of drug targets for a diverse array of pathophysiological ...

• Design and synthesis of novel pH-responsive fatty acid-based lipids for the development of nano-delivery systems to enhance Vancomycin activity against Methicillin-resistant Staphylococcus aureus (MRSA). 

  Makhathini, Sifiso Sakhiseni. (2020)

  The ability of antimicrobials to prevent and treat infections caused by a range of microorganisms, including bacteria, is threatened by the emergence of drug-resistant microorganisms that is associated with high mortality ...

• The effects of naringenin on oxidative stress parameters in cardiac muscles of diabetic rats. 

  Mcobothi, Nosibusiso Esethu. (2019)

  Introduction: Diabetic cardiomyopathy (DCM) is defined by hypertrophy, oxidative stress, fibrosis and inflammation of the cardiac muscle. Hyperglycemia-associated oxidative stress plays an important role in the development ...

• Synthesis and physiochemical characterization of new siderophore-inspired peptide-chelators with 1-hydroxypridine-2-one (1,2-HOPO). 

  Alshaer, Danah Mahdi Mohammad. (2020)

  Compounds containing hydroxamate moieties (N-hydroxyl amides) in their structure have found a vast range of therapeutic applications such as antibacterial, anti-tumour, anti-immune suppressor, and for iron overloading ...

• The role of kinins and cytokines in rheumatoid arthritis. 

  Cassim, Bilkish. (2001)

  Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by inflammatory synovitis. The histopathological features include synovial hyperplasia, an inflammatory cell infiltration, angiogenesis ...

• An evaluation of knowledge, attitude and behaviour amongst patients regarding antibiotic use and misuse in South Africa. 

  Ballaram, Sholene. (2020)

  Background: Antibiotic misuse is a global problem that presents a threat to public health. Antibiotic misuse and overuse are responsible for the increase and spread of antibiotic resistance. The community plays a fundamental ...

• Therapeutic strategy to end Tuberculosis (TB) world: structural and functional characterization of potential weak hotspots of Mycobacterium tuberculosis molecular targets from combinatorial in silico perspective. 

  Adewumi, Adeniyi Thompson. (2021)

  The world has witnessed several decades of Tuberculosis (TB) pandemic and numerous advanced scientific efforts to control the invasiveness of the newly evolving Mycobacterium tuberculosis strains (Mtb) resulting in drug ...

• Computer-aided approaches in drug design: the exigent way forward: dynamic perspectives into the mechanistic activities of small molecule inhibitors toward antiviral, antitubercular and anticancer therapeutic interventions. 

  Agoni, Clement. (2021)

  The crucial role of CADD in the drug design process is now indisputable and has proven over the years that it can accelerate the discovery potential drug candidates while reducing the associated cost. Using knowledge and ...

• Vasoactive peptides in acute renal allograft rejection and renal diseases: the role of endothelins, atrial natriuretic peptide and kinins. 

  Naicker, Saraladevi. (2001)

  Abstract available in PDF.

• Impact of Duffy Antigen Receptor for Chemokines (DARC)-null linked Neutropenia on Neutrophil and Natural Killer cell Function in HIV-1 Infection. 

  Naidoo, Kewreshini Kasturi. (2018)

  Sub-Saharan Africa carries a disproportionate burden of the HIV-1 epidemic. The Duffy Antigen Receptor for Chemokines (DARC)-null polymorphism is a predictor of ethnic neutropenia which commonly occurs in persons of African ...

• Prevalence and distribution of visual impairment, refractive error and their impact on quality of life among school-going children aged 6-18 years in Sekhukhune District (Limpopo), South Africa. 

  Magakwe, Tshubelela Sello Simon. (2020)

  Background: Refractive error (RE) and visual impairment (VI) remain major problems affecting school going children worldwide and impacting their quality of life. Aim: To determine the prevalence and distribution of RE and ...

• Assessment of visual function amongst motor vehicle drivers in Maseru, Lesotho. 

  Moledi, Zubeta. (2021)

  Background: Driving is a primary mode of travel in many countries. It relies primarily on the function of vision to navigate roads and traffic safely. Ensuring good vision for motor vehicle drivers is therefore important ...

• Validation of selected iPhone optometric screening applications in vision screening. 

  Moodley, Therisha. (2020)

  Introduction: There has been an unprecedent increase in the use of mobile technology to provide health care services. The eye care industry has also adopted the use of these innovative smart-technology devices to provide ...

• A survey of traditional eye practices: a case study of the central region of Ghana. 

  Enimah, Eugene Buah. (2020)

  Background: Once one becomes dependent on the eyes, loss of vision can negatively impact person-social and psychological well-being with added financial constraints. Studies have shown that apart from attending the healthcare ...

• An evaluation of the accuracy of the Moorfields Motion Displacement Test. 

  Chetty, Keshia. (2020)

  Introduction: Recent statistics report a global blind population of 32.4 million and 191 million people with vision impairment, of which more than 90% of the world’s visually impaired live in developing countries. Glaucoma, ...

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