Design, synthesis and biological evaluation of antimicrobial agents: bromopyrrole-cinnamaldehyde hybrids.

Abstract

Antimicrobial resistance threatens the effective prevention and treatment of an increasing range of Infections. The ongoing discovery of newer antimicrobial resistance has been a driving energy in the design, synthesis and development of newer antimicrobial agents. As a contribution to these efforts, we synthesized novel Bromopyrrole-Cinnamaldehyde Hybrids compounds. A series of fifteen Bromopyrrole-Cinnamaldehyde Hybrids molecules were synthesized by molecular hybridization approach. In vitro anti-mycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, 4(b-e) exhibited activity (MIC >20 μM; IC50 = >20 μM) furthermore the sythesised hybrids displayed promising activity against tested fungal strains, in particular for clinical isolate of C. neoformans with MIC values ranging from 12.5 – 25 μg/mL. All synthesized compounds were confirmed by melting point, FT-IR, 1H-NMR and 13C-NMR spectroscopy. The yield of these compounds obtained ranged from 40% to 80%.