Repository logo
 

Design, synthesis and biological evaluation of antimicrobial agents: bromopyrrole-cinnamaldehyde hybrids.

Thumbnail Image

Date

2018

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Antimicrobial resistance threatens the effective prevention and treatment of an increasing range of Infections. The ongoing discovery of newer antimicrobial resistance has been a driving energy in the design, synthesis and development of newer antimicrobial agents. As a contribution to these efforts, we synthesized novel Bromopyrrole-Cinnamaldehyde Hybrids compounds. A series of fifteen Bromopyrrole-Cinnamaldehyde Hybrids molecules were synthesized by molecular hybridization approach. In vitro anti-mycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, 4(b-e) exhibited activity (MIC >20 μM; IC50 = >20 μM) furthermore the sythesised hybrids displayed promising activity against tested fungal strains, in particular for clinical isolate of C. neoformans with MIC values ranging from 12.5 – 25 μg/mL. All synthesized compounds were confirmed by melting point, FT-IR, 1H-NMR and 13C-NMR spectroscopy. The yield of these compounds obtained ranged from 40% to 80%.

Description

Masters Degree. University of KwaZulu-Natal, Durban.

Keywords

Citation

DOI