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dc.creatorPatel, V. B.
dc.creatorPadayatchi, Nesri.
dc.creatorBhigjee, Ahmed Iqbal.
dc.creatorAllen, J.
dc.creatorBhagwan, B.
dc.creatorMoodley, A. A.
dc.creatorMthiyane, T.
dc.date.accessioned2013-04-29T08:45:51Z
dc.date.available2013-04-29T08:45:51Z
dc.date.created2003
dc.date.issued2003
dc.identifier.citationPatel, V.B., et al. 2004. Multidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa. Clin Infect Dis. 38(6) pp. 851-6.en
dc.identifier.issn1058-4838
dc.identifier.urihttp://dx.doi.org/10.1086/381973en
dc.identifier.urihttp://hdl.handle.net/10413/8807
dc.description.abstractMultidrug-resistant (MDR) pulmonary tuberculosis (TB) is well described in the literature. Reports of MDR TB meningitis (MDR-TBM), however, are limited to case reports and a single case series. During the period of 1999-2002, 350 patients with TBM were identified by cerebrospinal fluid culture for TB. Thirty patients (8.6%) had TB that was resistant to at least isoniazid and rifampicin. All 30 patients were included in this study. We reviewed hospital charts of the patients with MDR-TBM and describe our experience. Seventeen patients with MDR-TBM died, and, of those who were known to be alive, many experienced significant morbidity. Eighteen patients were HIV positive. Twenty-two patients had been treated for TB in the past, 3 patients had received no previous treatment for TB, and the history of TB treatment was unknown for 5 patients. The study highlights the prevalence of MDR-TBM and identifies new challenges in the management of affected patients.en
dc.language.isoenen
dc.publisherThe Infectious Diseases Society of America.en
dc.subjectMultidrug-resistant tuberculosis--KwaZulu-Natal.en
dc.subject.otherMultidrug-resistant tuberculous meningitis.en
dc.subject.otherMDR-TBM.en
dc.titleMultidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa.en
dc.typePeer reviewed journal articleen


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