Multidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa.
| dc.contributor.author | Patel, Vinod B. | |
| dc.contributor.author | Padayatchi, Nesri. | |
| dc.contributor.author | Bhigjee, Ahmed Iqbal. | |
| dc.contributor.author | Allen, J. | |
| dc.contributor.author | Bhagwan, B. | |
| dc.contributor.author | Moodley, A. A. | |
| dc.contributor.author | Mthiyane, T. | |
| dc.date.accessioned | 2013-04-29T08:45:51Z | |
| dc.date.available | 2013-04-29T08:45:51Z | |
| dc.date.created | 2003 | |
| dc.date.issued | 2003 | |
| dc.description.abstract | Multidrug-resistant (MDR) pulmonary tuberculosis (TB) is well described in the literature. Reports of MDR TB meningitis (MDR-TBM), however, are limited to case reports and a single case series. During the period of 1999-2002, 350 patients with TBM were identified by cerebrospinal fluid culture for TB. Thirty patients (8.6%) had TB that was resistant to at least isoniazid and rifampicin. All 30 patients were included in this study. We reviewed hospital charts of the patients with MDR-TBM and describe our experience. Seventeen patients with MDR-TBM died, and, of those who were known to be alive, many experienced significant morbidity. Eighteen patients were HIV positive. Twenty-two patients had been treated for TB in the past, 3 patients had received no previous treatment for TB, and the history of TB treatment was unknown for 5 patients. The study highlights the prevalence of MDR-TBM and identifies new challenges in the management of affected patients. | en |
| dc.identifier.citation | Patel, V.B., et al. 2004. Multidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa. Clin Infect Dis. 38(6) pp. 851-6. | en |
| dc.identifier.issn | 1058-4838 | |
| dc.identifier.uri | http://dx.doi.org/10.1086/381973 | en |
| dc.identifier.uri | http://hdl.handle.net/10413/8807 | |
| dc.language.iso | en | en |
| dc.publisher | The Infectious Diseases Society of America. | en |
| dc.subject | Multidrug-resistant tuberculosis--KwaZulu-Natal. | en |
| dc.subject.other | Multidrug-resistant tuberculous meningitis. | en |
| dc.subject.other | MDR-TBM. | en |
| dc.title | Multidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa. | en |
| dc.type | Peer reviewed journal article | en |