School of Laboratory Medicine & Medical Sciences
Sub-communities within this community
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Anatomy [18]
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Chemical Pathology [13]
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HIV Medicine [2]
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Medical Biochemistry [52]
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Medical Microbiology [72]
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Medical Science [30]
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Optics and Imaging [26]
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Physiology [96]
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Virology [38]
Recent Submissions
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The pathophysiology of cholesterol gallstones amongst Black South African women living with HIV.
(2021)Thirteen percent of South Africans are living with HIV and of those infected, 52% are on antiretroviral therapy (ART). ART has changed the course of this terminal illness to one of a chronic illness. However, the longer ... -
An investigation into the molecular and Epigenetic alterations associated with Fumonisin B1-induced toxicity in human liver (HEPG2) cells.
(2020)The contamination of agricultural commodities with Fusarium mycotoxins is a global issue in food safety, with fumonisin B1 (FB1) being the most prevalent contaminant. FB1 is not only phytotoxic, but it induces a wide range ... -
An investigation into the biochemical effects of Kojic acid (KA) on human hepatocellular carcinoma (HepG2) cells.
(2020)Kojic acid (KA) is a secondary metabolite and divalent metal chelator that is widely used in the beauty industry as a skin lightener. However, KA toxicity is not well-established in humans. This study aimed to determine ... -
The alteration of dopamine receptors in L-DOPA (L-3,4-dihydroxyphenylalanine) induced dyskinesias.
(2021)L-3,4-dihydroxyphenylalanine (L-DOPA) can ease symptoms of Parkinson’s disease (PD), butextended use of L-DOPA causes abnormal involuntary movements (AIMs) called L-DOPA induced dyskinesias (LIDs). The present study aims ... -
Role of neuroinflammation in an amyloid-beta model of Alzheimer’s disease and the identification of possible biomarker.
(2020)Introduction. Alzheimer's disease (AD) is the most common form of neurodegenerative disorder that results in dementia. It currently affects 75 million people worldwide and is predicted to affect as many as 135 million ... -
Impact of quercetin-3-0-rutinoside on biochemical and reproductive profile of rats prenatally exposed to high fat diet.
(2020)The increasing prevalence of infertility and obesity over the last few decades have become a major public health challenge among individuals within the reproductive age. Consumption of a high-fat diet (HFD) is a harbinger ... -
Biomarkers and histopathologic changes in rats with monocrotaline-induced pulmonary hypertension following administration of antiretroviral medications.
(2020)Pulmonary hypertension (PH) is a progressive life-threatening vasculopathy characterized by dysregulated pulmonary vascular remodelling that results in an increased pulmonary vascular resistance, right ventricular ... -
Investigating immune metabolism and exhaustion in Type 2 Diabetes.
(2020)Introduction In the era of rapid modernisation and urbanisation, the global incidence of non-communicable diseases such as type 2 diabetes (T2D) has significantly increased. This has been attributed to increased sedentary ... -
The determination of unilateral ratios (knee and shoulder muscle strength), of provincial cricketers.
(2002)Abstract available in PDF. -
Calymmatobacterium granulomatis: culture, electron microscopic studies and molecular analysis.
(1997)Abstract available in PDF. -
The effect of infra-red laser therapy on fibroblast activity in cell culture.
(1997)Abstract available in PDF. -
The activity of nybomycin against mycobacterium tuberculosis.
(2018)Nybomycin was discovered in 1955, but was never developed for clinical use. The compound was noticed again in recent years when it displayed bactericidal activity against certain fluoroquinolone-resistant bacterial species. ... -
The role of heparin binding haemagglutinin adhesin and curli pili on the pathogenicity of Mycobacterium tuberculosis.
(2018)Background: Phagocytic host cells drive both the innate and adaptive arms of the host immune response during Mycobacterium tuberculosis (M. tuberculosis) infection. M. tuberculosis modulates the host immune responses and ... -
The role of immunoglobulin isotypes (IgG1-IgG4, IgA AND IgM) in HIV preeclamptics on highly active anti-retroviral therapy, in South Africa.
(2018)Background: The epicentre of a successful pregnancy lies within the placenta and is nurtured by suppressed immune responses. However, the fragile balance between maternal inflammatory responses and the regulation of maternal ... -
Fumonisin B1 induced antioxidant response in C57BL/6 male mice brain.
(2018)Background: Fumonisin B1 (FB1), a mycotoxin produced by the Fusarium species, contaminates maize. In South Africa maize is a dietary staple and FB1 endangers human and animal health. FB1 is known to have neurodegenerative ... -
The role of basic fibroblast growth factor in HIV associated preeclampsia.
(2018)Background: In South Africa, hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality, however, little is known about the prevalence and distribution of HBV in some regions and populations. Methods: ...
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