• Evaluating the role of maternal separation stress on the development of autistic-like behaviour in Sprague-Dawley rats. 

  Heeralall, Chanel. (2020)

  Autism Spectrum Disorders (ASD) are a category of neurodevelopmental disorders that have become more prevalent, causing much concern. Autistic individuals display symptoms ranging from repetitive behaviours to communication ...

• The role of soluble e-selectin and thrombospondin-2 in HIV associated preeclampsia. 

  Naidoo, Girija. (2019)

  Objective: HIV infection and hypertensive disorders of pregnancy are common causes of maternal mortality in South Africa. Preeclampsia (PE) is a pregnancy-specific disorder that contributes to the majority of maternal ...

• Evaluating immune activation and cellular determinants of thrombosis in pre-diabetes. 

  Mkandla, Zibusiso. (2018)

  Introduction Platelet dysregulation in pre-diabetes plays a major role in the progression of prothrombotic and pro-inflammatory conditions. Cardiovascular disease (CVD), which may occur at the pre-diabetic stage, are a ...

• Investigating the effects of bredemolic acid on selected markers of some prediabetes-associated dysfunctions in diet-induced prediabetic rats. 

  Akinnuga, Akinjide Moses. (2019)

  Prediabetes is an abnormal glycaemic state between normoglycaemia and chronic hyperglycaemia which is currently prevalent in developing and developed countries due to increased consumption of high caloric diet coupled with ...

• Investigating the biomarker potential of exosomes in preeclampsia. 

  Pillay, Preenan. (2019)

  Preeclampsia is a hypertensive disorder of pregnancy and one of the leading causes of maternal and perinatal morbidity, affecting up to 7 -10% of pregnancies globally which results in 50 000-76 000 maternal deaths per year ...

• Effects of antipsychotic dose reduction on metabolic syndrome in patients with first episode psychosis treated with a long-acting injectable antipsychotic. 

  Ndlangisa, Ziyanda Lynn. (2019)

  Background: The introduction of antipsychotics has been a significant milestone in the treatment of schizophrenia. However, these agents have several important side effects, such as metabolic syndrome. Options to curb these ...

• The role of Vascular Endothelial growth factor receptor-3 in the placenta in HIV associated preeclampsia. 

  Pillay, Saieshni. (2019)

  Summary: PE and HIV dualism in pregnant HAART women are yet to be investigated. Furthermore, the effect on VEGFR-3 and subsequent downstream influence on angiogenesis is poorly understood. Therefore, this investigation ...

• Effects of momordica balsamina on glucose handling in high fat high carbohydrate induced prediabetic rat model and glucose handling in C2C12 induced insulin resistant cell lines: effects on selected metabolic markers. 

  Khumalo, Bongiwe. (2020)

  Increased consumption of fat and high carbohydrate coincided with increased prevalence in type 2 diabetes, a condition whose onset is always preceded by prediabetes. Prediabetes is best characterised by hyperglycaemia, ...

• The cytotoxic effects, anti-iflammatory, antioxidant, antibacterial, and antidiabetic properties of eight selected South African plants for medicinal purposes. 

  Nkala, Bongani Alphouse. (2020)

  People from the Southern African region have been using the fauna and flora of the region in their homes for millennia to treat all sorts of ailments and complaints with great success. This knowledge transfer was done ...

• An evaluation of the chemical composition and the in vitro and in vivo antihypertensive activity of extracts of Tulbaghia acutiloba Harv. in an L-NAME induced hypertensive model. 

  Arhin, Isaiah. (2019)

  The increasing prevalence of hypertension over the years has been identified as a major contributor to high morbidity and mortality, globally and locally, in Africa, posing a serious global health threat. The demand for ...

• The effects of prenatal stress on the preoptic nuclei of febrile seizure rat models. 

  Malik, Yasmin. (2019)

  Febrile seizures are a neurological abnormality that occurs after an underlying systemic infection, leading to fever and followed by convulsions due to neuronal hyper-excitability. Although regarded as benign, prenatal ...

• Gene polymorphisms of uric acid related proteins and the Angiotensin Receptor IV (AT4) in Pre-eclampsia. 

  Khaliq, Olive Pearl. (2019)

  Background: Hypertensive disorders of pregnancy remain one of the major contributions to maternal and fetal morbidity and mortality around the globe. Pre-eclampsia is a hypertensive disorder of pregnancy which complicates ...

• The impact of the introduction of direct first and second-line reflex testing in the management of drug-resistant Tuberculosis at Greytown Hospital, Umzinyathi District, KwaZulu-Natal. 

  Sneyd, Tamara. (2020)

  Background Drug resistant tuberculosis (DR-TB) is a serious public health issue both globally and nationally, with South Africa and Kwazulu-Natal, in particular, being among the regions with the highest burden of DR-TB. ...

• Lung tissue resident memory T and B cells in the immune response to Mycobacterium tuberculosis in humans. 

  Ogongo, Paul Ochieng. (2019)

  Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is the main cause of death from a single infectious agent. Although a quarter of the world population is estimated to be infected with TB, only 5–10% of these ...

• Mycobacterium tuberculosis pili (MTP) modulates pathogen and host metabolomic changes in an A549 epithelial cell model of infection. 

  Reedoy, Kajal Soulakshana. (2020)

  Background/Aim: Mycobacterium tuberculosis, the causative organism of tuberculosis, continues to drive research efforts in the quest to develop novel diagnostics and therapeutics. The complexities associated with drug-resistant ...

• The role of neuroinflammatory markers in a preeclamptic rat model. 

  Ijomone, Olayemi Kafilat. (2020)

  Introduction: Preeclampsia (PE) is a clinical complication of pregnancy characterised with the new onset of hypertension and proteinuria, and/or organ dysfunction. Globally, it is associated with maternal and perinatal ...

• Transepithelial migration of Mycobacterium tuberculosis strains and their affinity for glial cells in vitro. 

  Nkwagatse, Taetso. (2019)

  Background: Tuberculosis is an infectious disease caused by the bacillus M. tuberculosis. It is a disease that mainly infects the lungs, however, almost any other organ of the body can be infected. Central nervous system ...

• The interaction between nutrition, immunity and coinfections with human immunodeficiency virus and intestinal parasites in South African adults: investigating the use of prealbumin as a tool for nutritional assessment. 

  Mkhize, Brenda Thabisile. (2019)

  Highly prevalent HIV and helminth single infections continue to plague a significant proportion of the South African population. The geographic overlap of these infections lands to the expectation that high prevalence of ...

• Systemic lymphocyte trafficking markers in TB and TB/HIV co-infections. 

  Pillay, Kimesha. (2019)

  Background. Several studies demonstrate that immune inflammation and trafficking of immune cells to affected tissues plays a major role in the pathogenesis of tuberculosis (TB) and human immunodeficiency virus (HIV) ...

• The role of Endothelin-1 in HIV associated pre-eclampsia. 

  Mthembu, Mbuso Herald. (2019)

  Introduction and Background: Preeclampsia (PE), a hypertensive disorder specific to human pregnancy, remains a major cause of maternal mortality and morbidity globally. Endothelin-1 (ET-1) is a powerful vasoconstrictor ...

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