• T cell function and immune checkpoint inhibition in chronic lymphocytic leukaemia. 

  Mkhwanazi, Zekhethelo Alondwe. (2021)

  Background: The global burden of lymphoid malignancies gradually increased over the past decade, with chronic lymphocytic leukaemia (CLL) accounting for a quarter of the burden of all haematological malignancies. ...

• The effect of prenatal Mycobacterium tuberculosis infection on offspring neurodevelopment and autistic-like behaviours in a valproic acid mouse model of autism. 

  Manjeese, Wadzanai. (2021)

  Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted repetitive patterns, communication challenges and lack of social skills. ASD has no distinct biomarkers, with symptoms overlapping ...

• The acute effects of dioxidovanadium on blood glucose concentration and oxidative stress in the hippocampus of non-diabetic male Sprague Dawley rats and the chronic effects of dioxidovanadium on selected markers associated with hippocampal dysfunction in male streptozotocin-induced diabetic rats. 

  Dayanand, Yalka. (2022)

  Diabetes mellitus is a disease associated with derangements in glucose metabolism and chronic hyperglycaemia. Chronic hyperglycaemia induces oxidative stress and inflammation that affect glucose sensitive hippocampal neurons ...

• Evaluation of the potential benefits of L-ergothioneine on selected complications associated with type-2 diabetes in a rat model. 

  Dare, Ayobami. (2021)

  Several pathogenic factors promote type-2 diabetic complications in patients, including cardiomyopathy, nephropathy, and non-alcoholic fatty liver disease (NAFLD). Specific nutraceuticals from food may act as a medicinal ...

• Investigating the effects of diet-induced pre-diabetes on calcium homeostasis in male Sprague Dawley rats. 

  Naidoo, Karishma. (2022)

  Diabetes mellitus (DM) affects over 400 million people worldwide with 90-95% being type 2 diabetes mellitus (T2DM) in South Africa. T2DM is positively correlated with the chronic consumption of a high caloric diet, often ...

• Local experience of patients with connective tissue associated interstitial lung disease who were treated with cyclophosphamide. 

  Singh, Swasti Gitesh. (2021)

  Introduction: Interstitial lung disease (ILD) is a major cause of death amongst individuals with connective tissue diseases (CTD). Although there is no cure for CTD-ILD the need to retard disease progression is vital, ...

• The impact of semen exposure on cytokine response and bacterial vaginosis in the female genital tract. 

  Mngomezulu, Khanyisile Happiness. (2018)

  Background: Diverse microbial communities and inflammatory cytokine responses in the lower female genital tract (FGT) are closely associated with increased human immunodeficiency virus (HIV-1) risk, possibly through ...

• Molecular surveillance of Staphylococcus aureus on frequently touched sites in public hospitals in KwaZulu-Natal, South Africa. 

  Mkhize, Siyethaba. (2021)

  There is an escalation in the prevalence of hospital-acquired infections (HAI) due to the transfer of pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), within the hospital environment. Pathogens ...

• Distribution, virulence and antimicrobial resistance profile of Bacillus species from the environment of four public hospitals in South Africa. 

  Mbhele, Zamile Nompumelelo. (2021)

  Hospital-acquired infections (HAIs) are counted as the most crucial global health crisis. The hospital environment may be colonized by opportunistic pathogens, which can lead to HAIs in hospitalized patients. As a result, ...

• The impact of semen exposure on the immune and microbial environments of the female genital tract. 

  Jewanraj, Janine. (2021)

  Background: Semen is an immunomodulatory fluid that induces mucosal changes at the female genital tract (FGT) for sperm survival and conception. Semen-induced alterations necessary for reproduction may also modulate the ...

• Molecular epidemiology of antibiotic-resistant Escherichia coli and Enterococcus spp. from agricultural soil fertilized with chicken litter in uMgungundlovu district, KwaZulu-Natal Province, South Africa. 

  Fatoba, Dorcas Oladayo. (2021)

  The application of animal manure contaminated with antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) represents a major route by which antibiotic resistance is transmitted into the soil environment. ...

• Prevention of HIV-1 acquisition and determinants of disease progression. 

  Moyano De Las Muelas, Ana. (2021)

  Introduction HIV-1 infection can be managed using multiple strategies, including preventative approaches and therapeutic approaches. Current preventative and treatment strategies are suboptimal and there is a need ...

• A pilot study: bisphenol A-glucuronide and their association with sex steroid hormones and 25 Hydroxy vitamin D among mother and child pairs. 

  Gounden, Verena. (2021)

  Bisphenol A (BPA) is an endocrine disruptor that has become ubiquitous in our environment. It is utilised in numerous consumer products related to the manufacture of plastics. Exposure to BPA has been linked to a wide ...

• The role of Nef-mediated SERINC5 down-regulation on HIV-1 disease progression. 

  Naicker, Marshlin Delon. (2021)

  HIV-1 Nef is a small accessory protein that plays a vital role in enhancing HIV-1 pathogenesis, evidenced by a strongly attenuated disease course following infection with a virus with gross Nef defects. Nef has multiple ...

• The impact of antiretroviral therapy and Immunological factors on preterm and small for gestational age deliveries in HIV infected pregnant women. 

  Mdletshe, Nontlantla Cecilia. (2020)

  Introduction Antiretroviral therapy (ART) during pregnancy may be associated with an increased risk of adverse pregnancy outcomes, including preterm delivery (PTD) and small-for-gestational-age (SGA) but the underlying ...

• Developmental changes of the facial skeleton from birth to 18 years within a South African cohort: a computed tomography study. 

  Niemann, Kristen. (2021)

  Introduction: The facial skeleton or viscerocranium has been recently noted as a method for age estimation as its development is influenced not only by the developing paranasal air sinuses and tooth eruption, but also the ...

• Impact of Duffy Antigen Receptor for Chemokine (DARC)-null polymorphism on T cell function and pro-inflammatory cytokine responses during HIV-1 infection. 

  Shangase, Zesuliwe Barbrah. (2018)

• Hydrogen sulfide (H2S) production by mycobacteria. 

  Kunota, Tafara Takunda Remigio. (2020)

  The gasotransmitter hydrogen sulfide (H2S) has been recognized as a physiological mediator with a variety of functions across all domains of life. Many prokaryotic bacterial species endogenously generate H2S in their ...

• HIV cell-to-cell spread leads to a differential transcriptional response and slows evolution of drug resistance relative to cell-free infection. 

  Hunter, Jessica Rose. (2020)

  HIV transmits between hosts but also transmits between cells in the same host. How this latter, cellular transmission occurs has been the subject of extensive study. Yet why HIV transmits between cells using two different ...

• Mucosal-associated invariant T (MAIT) cell heterogeneity in peripheral blood and bronchoalveolar compartment: implications for TB and HIV immunity. 

  Khuzwayo, Sharon Jabu. (2020)

  Tuberculosis (TB) is the leading cause of infectious mortality globally and the leading cause of death in people living with human immunodeficiency virus (HIV). Understanding the mechanisms leading to impaired anti-TB ...

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