• Evaluation of teixobactin derivatives as potential antimicrobial agents. 

  Ramchuran, Estelle Juanita. (2017)

  Methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus (VRE) are on the World Health Organization (WHO) high priority list of pathogens that require serious attention. Therefore, the ...

• Genetic characterization of viral blips in patients following suppressive HIV ART. 

  Jhamba, Lindiwe Amanda. (2021)

  Antiretroviral therapy (ART) has resulted in the decline of HIV-related mortality worldwide. On initiating treatment, most patients can suppress plasma viral RNA to undetectable levels (<20 copies/mL). Patients on ART ...

• Impact of Chlamydia trachomatis on inhibitory capabilities of broadly neutralizing antibodies in vitro. 

  Magini, Stanley Nzuzo. (2021)

  Abstract available in PDF.

• HIV-1 integrase inhibitor mutations: analysis of structural and biochemical effects. 

  Mbhele, Nokuzola Brightness. (2021)

  Introduction. Combination antiretroviral therapy (cART), composed of drugs from different drug classes, is an effective HIV-1 treatment strategy. As part of cART, integrase strand transfer inhibitors (INSTIs) have become ...

• Biochemical characterization of highly mutated South African HIV-1 subtype C protease. 

  Eche, Simeon. (2021)

  Understanding the underlying molecular mechanism of HIV-1 protease (PR) inhibition by HIV-1 protease inhibitors (PIs) is essential to gain mechanistic insight into the evolution of resistance to HIV-1 PIs. HIV-1 PIs have ...

• Terminalia phanerophlebia crude aqueous leaf extract activates the NRF2-mediated antioxidant defence to prevent oxidative stress in human hepatocellular carcinoma cells. 

  Nyahada, Marcilyn Rutendo. (2021)

  Abstract available in PDF.

• Causes of meningitis in the era of HIV. 

  Ramjathan, Praksha. (2021)

  No abstract available.

• Microbial profile and antimicrobial susceptibility patterns of neonatal blood stream infections in Durban, South Africa. 

  Pillay, Dharshni. (2020)

  Objectives Antimicrobial resistance (AMR) has emerged as a global threat to healthcare resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third highest cause of neonatal demise globally, ...

• Molecular epidemiology of antibiotic resistant salmonella spp. from farm to fork in an intensive pig production system in KwaZulu-Natal South Africa. 

  Tshakane, Nozipho Pamela. (2021)

  Antibiotic resistance (ABR) is a worldwide challenge, and, if not resolved, can be a danger to humans, animals and the ecosystem. The inappropriate use and misuse of antibiotics in food animal production creates selection ...

• Defining the role of high-dose isoniazid in the treatment of multi-drug resistance tuberculosis: isoniazid resistant profiling. 

  Ngema, Senamile Lale. (2021)

  Background: High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (MDR-TB). However, there is no substantial evidence supporting its use in the presence of INH resistant mutations. ...

• Using neutrophil-specific biomarkers as a measure of Mycobacterium tuberculosis burden, lung damage and treatment response kinetics. 

  Ndlovu, Lerato Noluthando. (2021)

  The spectrum of TB disease remains poorly characterized impacting case identification and linkage to care. Furthermore, the absence of simple, sensitive and easy to measure biomarkers of disease severity and treatment ...

• The role of Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) on global in vitro bacterial transcriptomics. 

  Naidoo, Tarien Jael. (2021)

  Background/Aim: Tuberculosis (TB), is an infectious, airborne disease caused by Mycobacterium tuberculosis (M. tuberculosis). TB remains one of the most devastating bacterial causes of human mortality, especially in ...

• Fosfomycin: an oral treatment option for multi drug resistant uropathogens. 

  Naidoo, Alicia. (2021)

  Introduction Urinary tract infections (UTIs) are commonplace in both the community and hospital environment where it is accepted clinical practice to treat empirically. Consequently, this has led to an alarming increase ...

• The prevalence of Methicillin-resistant Staphylococcus aureus in blood product hampers at the South African National Blood Service. 

  Seoraj, Varsha. (2021)

  Background: Methicillin-resistant Staphylococcus aureus (MRSA), are strains of the Gram-positive cocci known to cause various health conditions. Patients suffer from abscesses, skin infections and more severe conditions ...

• Exploring Iso-mukaadial acetates and other small compounds as inhibitors of recombinant Plasmodium falciparum lactate dehydrogenase. 

  Mabaso, Nonduduzo Hlengiwe. (2021)

  Malaria is a major killer disease in Sub-Saharan Africa, this disease is caused by a protozoan parasite of genus Plasmodium. It is a pressing health issue the public is facing, and the effectiveness of every treatment ...

• Anterior synostotic plagiocephaly: a quantitative analysis of craniofacial features using computed tomography. 

  Mohan, Nivana. (2021)

  Anterior synostotic plagiocephaly (ASP) is caused by the premature fusion of one coronal suture, which results in severe craniofacial asymmetry that can be challenging to correct. The various methods of the surgical ...

• Scaphocephaly in a select South African population: a morphometric analysis of the cranial fossae and ventricular access points. 

  Bisetty, Vensuya. (2021)

  Scaphocephaly is a cranial deformity that results from premature fusion of the sagittal suture and is characterized by an elongated and narrowed skull. Patients with this condition present with varying clinical features ...

• An anatomical investigation of intracranial meningiomas. 

  Anirudh, Ezra Earl. (2021)

  Meningiomas are generally benign, highly vascularised, slow-growing tumours arising from the arachnoid cap cells of the arachnoid villi. The clinical presentation of these tumours is usually location dependant due to the ...

• A morphologic and immunohistochemical appraisal of invasive breast carcinomas with neuroendocrine differentiation. 

  Naicker, Nimallen. (2021)

  Background: Invasive breast carcinomas with neuroendocrine differentiation (IBCNED) are a heterogenous group of tumours first recognised, as a distinct entity, by the World Health Organisation (WHO) in 2003. The classification ...

• Identification of mutations in genes associated with metronidazole resistance and susceptibility in Trichomonas vaginalis. 

  Mzenda, Tumelo. (2021)

  Trichomonas vaginalis is the most common non-viral, sexually transmitted pathogen worldwide. Although, metronidazole cure rates are high for T. vaginalis infection, resistance has been reported. Mutations in the nitroreductase ...

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