• An investigation into the neurochemical and behavioural patterns of C57Bl6 mice exposed to "Sugars" and its constituents. 

  Chetty, Yvette Yolanda. (2020)

  “Sugars” is an illicit drug cocktail that is a low-grade mixture of heroin and other opioids. The composition of this cocktail is highly varied as other ingredients are added during its manufacturing process to add bulk ...

• A descriptive analysis of the routine use of genotype MTBDRsl in a high HIV/TB prevalent region in South Africa. 

  Lutchminarain, Keeren. (2020)

  Background. Since the implementation of shortened drug regimens for the management of drug resistant tuberculosis (TB), there is a growing need for rapid detection of resistance to second line antimycobacterial drugs. The ...

• The effect of HIV and Neisseria gonorrhoeae on the tight junctions of cervical epithelial cells. 

  Maharaj, Shevani. (2020)

  Introduction: Neisseria gonorrhoeae and HIV are major public health concerns globally. The interaction between these diseases is unclear. To determine the effect that N. gonorrhoeae and HIV have on the tight junctions of ...

• The effect of isolated and nanoencapsulated flavonoids from Eriocephalus africanus on apoptotic factors and microRNA expression in cancer. 

  Magura, Judie. (2020)

  Cancer continues to be a major health burden worldwide, with millions of new cases being diagnosed each year. Among women breast cancer remains a leading cause of cancer-related morbidity and mortality globally, despite ...

• Evaluation of the therapeutic properties of a Ruthenium(ll) uracil-derived diimine complex on selected complications associated with diet-induced pre-diabetes. 

  Mabuza, Lindokuhle Patience. (2019)

  Pre-diabetes is a chronic metabolic condition where blood glucose levels are above the upper threshold considered normal but below the threshold for a diagnosis of diabetes. Pre-diabetes predisposes individuals to a high ...

• A comparison of 24-hour urine versus random urine samples for determination and quantification of Bence Jones protein in a South African population. 

  Reddy, Ashandree. (2019)

  Objectives: The International Myeloma Working Group (IMWG) and College of American Pathologists recommend a 24-hour collection for Bence Jones proteins(BJP). Although a 24-hour urine collection is a definitive means to ...

• Identifying novel transcriptional regulatory elements of HLA-A alleles through the evaluation of the 5’ un-translated region sequences. 

  Singh, Saiyuri. (2020)

  Sub-Saharan Africa holds approximately half the population living with human immunodeficiency virus (HIV) in the world (~19.6 million), of which around 7.2 million cases are found in South Africa. Although antiretroviral ...

• The HIV-1 gag and protease: exploring the coevolving nature and structural implications of complex drug resistance mutational patterns in subtype C. 

  Marie, Veronna. (2019)

  Due to the high prevalence of HIV-1 subtype C infection coupled with increasing antiretroviral (ARV) drug treatment failure, the elucidation of complex resistance mutational patterns arsing through protein coevolution is ...

• Identifying the cellular HIV-1 reservoir in lymph nodes of antiretroviral therapy suppressed individuals. 

  Ferreira, Isabella Anna Theresa Markham. (2019)

  HIV-1 infection is suppressed but not cured in the face of antiretroviral therapy (ART). Pinpointing the cellular HIV-1 reservoir, which allows HIV-1 to persist, is key to the eradication of the virus. Lymph nodes are known ...

• The differential influence of HIV-1 subtype C,nucleoside analog resistance mutations: K65R, A62V, S68N and Y115F susceptibility to tenofovir. 

  Didamson, Onyisi Christiana. (2019)

  The use of Tenofovir Disoproxil Fumerate (TDF) for the treatment of HIV-1 infection has been recommended for the first-line as well as a second-line antiretroviral regimen in South Africa, due to its high antiretroviral ...

• Evaluating the role of maternal separation stress on the development of autistic-like behaviour in Sprague-Dawley rats. 

  Heeralall, Chanel. (2020)

  Autism Spectrum Disorders (ASD) are a category of neurodevelopmental disorders that have become more prevalent, causing much concern. Autistic individuals display symptoms ranging from repetitive behaviours to communication ...

• The role of soluble e-selectin and thrombospondin-2 in HIV associated preeclampsia. 

  Naidoo, Girija. (2019)

  Objective: HIV infection and hypertensive disorders of pregnancy are common causes of maternal mortality in South Africa. Preeclampsia (PE) is a pregnancy-specific disorder that contributes to the majority of maternal ...

• Evaluating immune activation and cellular determinants of thrombosis in pre-diabetes. 

  Mkandla, Zibusiso. (2018)

  Introduction Platelet dysregulation in pre-diabetes plays a major role in the progression of prothrombotic and pro-inflammatory conditions. Cardiovascular disease (CVD), which may occur at the pre-diabetic stage, are a ...

• Investigating the effects of bredemolic acid on selected markers of some prediabetes-associated dysfunctions in diet-induced prediabetic rats. 

  Akinnuga, Akinjide Moses. (2019)

  Prediabetes is an abnormal glycaemic state between normoglycaemia and chronic hyperglycaemia which is currently prevalent in developing and developed countries due to increased consumption of high caloric diet coupled with ...

• Investigating the biomarker potential of exosomes in preeclampsia. 

  Pillay, Preenan. (2019)

  Preeclampsia is a hypertensive disorder of pregnancy and one of the leading causes of maternal and perinatal morbidity, affecting up to 7 -10% of pregnancies globally which results in 50 000-76 000 maternal deaths per year ...

• Effects of antipsychotic dose reduction on metabolic syndrome in patients with first episode psychosis treated with a long-acting injectable antipsychotic. 

  Ndlangisa, Ziyanda Lynn. (2019)

  Background: The introduction of antipsychotics has been a significant milestone in the treatment of schizophrenia. However, these agents have several important side effects, such as metabolic syndrome. Options to curb these ...

• The role of Vascular Endothelial growth factor receptor-3 in the placenta in HIV associated preeclampsia. 

  Pillay, Saieshni. (2019)

  Summary: PE and HIV dualism in pregnant HAART women are yet to be investigated. Furthermore, the effect on VEGFR-3 and subsequent downstream influence on angiogenesis is poorly understood. Therefore, this investigation ...

• Effects of momordica balsamina on glucose handling in high fat high carbohydrate induced prediabetic rat model and glucose handling in C2C12 induced insulin resistant cell lines: effects on selected metabolic markers. 

  Khumalo, Bongiwe. (2020)

  Increased consumption of fat and high carbohydrate coincided with increased prevalence in type 2 diabetes, a condition whose onset is always preceded by prediabetes. Prediabetes is best characterised by hyperglycaemia, ...

• The cytotoxic effects, anti-iflammatory, antioxidant, antibacterial, and antidiabetic properties of eight selected South African plants for medicinal purposes. 

  Nkala, Bongani Alphouse. (2020)

  People from the Southern African region have been using the fauna and flora of the region in their homes for millennia to treat all sorts of ailments and complaints with great success. This knowledge transfer was done ...

• An evaluation of the chemical composition and the in vitro and in vivo antihypertensive activity of extracts of Tulbaghia acutiloba Harv. in an L-NAME induced hypertensive model. 

  Arhin, Isaiah. (2019)

  The increasing prevalence of hypertension over the years has been identified as a major contributor to high morbidity and mortality, globally and locally, in Africa, posing a serious global health threat. The demand for ...

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