• Login
    View Item 
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Laboratory Medicine & Medical Sciences
    • Medical Microbiology
    • Masters Degrees (Medical Microbiology)
    • View Item
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Laboratory Medicine & Medical Sciences
    • Medical Microbiology
    • Masters Degrees (Medical Microbiology)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Microbial profile and antimicrobial susceptibility patterns of neonatal blood stream infections in Durban, South Africa.

    Thumbnail
    View/Open
    Pillay_Dharshni_2020.pdf (6.839Mb)
    Date
    2020
    Author
    Pillay, Dharshni.
    Metadata
    Show full item record
    Abstract
    Objectives Antimicrobial resistance (AMR) has emerged as a global threat to healthcare resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third highest cause of neonatal demise globally, in which AMR accounted for 31.0% of deaths. This study analysed the aetiology and antimicrobial resistance patterns of bloodstream infections within the neonatal intensive care unit (NICU) at a tertiary hospital in Durban, South Africa. Methods A retrospective data review was conducted on all positive blood cultures at three time periods: 2014, 2016 and 2018. The organisms and antimicrobial susceptibilities were analysed for significant trends using Poisson and logistic regression. Results A preponderance of gram-positive organisms (68.7%) over gram-negatives (26.8%) and fungi (4.5%) was detected. Common pathogens included coagulase-negative staphylococci (53.5%), Klebsiella pneumoniae (11.6%), enterococci (9.3%), and Acinetobacter baumannii (7.7%). Late-onset sepsis (86.8%) predominated over early-onset sepsis (13.2%). High rates of resistance to first- and second-line antibiotics were noted among gram-positive and gramnegative organisms. Multidrug resistant organisms included extended-spectrum betalactamase (ESBL) K. pneumoniae (7.6%) and multi-drug resistant A. baumannii (7.0%). A statistically significant decrease in ESBL-producing organisms was documented between 2014 and 2018 (p = 0.005). Conclusion High resistance rates were seen for first- and second-line antibiotics used for the treatment of neonatal sepsis. Ongoing microbial surveillance is essential to tailor empiric antimicrobial choices in individual units.
    URI
    https://researchspace.ukzn.ac.za/handle/10413/20541
    Collections
    • Masters Degrees (Medical Microbiology) [66]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisorsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisorsType

    My Account

    LoginRegister

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV