• Login
    View Item 
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Laboratory Medicine & Medical Sciences
    • Medical Microbiology
    • Masters Degrees (Medical Microbiology)
    • View Item
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Laboratory Medicine & Medical Sciences
    • Medical Microbiology
    • Masters Degrees (Medical Microbiology)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effect of antimicrobials used for genital discharge disease on trichomonas vaginalis.

    Thumbnail
    View/Open
    Mabaso_Nonkululeko_ Gladness_ 2017.pdf (3.197Mb)
    Date
    2017
    Author
    Mabaso, Nonkululeko Gladness.
    Metadata
    Show full item record
    Abstract
    Trichomoniasis is the most common sexually transmitted infection caused by the protozoan, Trichomonas vaginalis. T. vaginalis infection is often asymptomatic. This infection causes vaginal discharge in women and urethritis in men. It has been reported that trichomoniasis is associated with serious health complications and it increases the risk of HIV acquisition and transmission. The gold standard for trichomoniasis diagnosis is culture, however various point of care tests have been approved by the US FDA. Metronidazole is the standard treatment for trichomoniasis. Multiple cases of metronidazole-resistance have been reported since 1962. Syndromic management of STIs is used to treat multiple infections simultaneously based on the signs and symptom with which the patient presents. In South Africa, the vaginal discharge syndrome is managed with ceftriaxone, azithromycin and metronidazole. Ten T. vaginalis isolate were tested. Each isolate was tested against six combinations of two antimicrobials by the checkerboard method, four combinations of three antimicrobials and two combinations of four antimicrobials. The results obtained from the checkerboard of two antimicrobials were used to design the experiments for three and four antimicrobials combinations. The MICs for metronidazole ranged between 0.25 – 1 μg/ml and for doxycycline, they ranged between 64 – 128 μg/ml. Ceftriaxone and fluconazole showed no antitrichomonal activity. All combinations tested has an indifferent effect. Combinations of metronidazole and antimicrobials used in syndromic management including fluconazole has no effect against T. vaginalis. However, in the combination of metronidazole and doxycycline a decrease in the MICs for these antibiotics was observed. Further studies are required to test this combination on a larger sample size.
    URI
    https://researchspace.ukzn.ac.za/handle/10413/16998
    Collections
    • Masters Degrees (Medical Microbiology) [41]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisorsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisorsType

    My Account

    LoginRegister

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV