Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology.
Abstract
Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.
Description
CAPRISA, 2014.
Keywords
HIV Infections/immunology., HIV-1/genetics., Cohort Studies.
Citation
Riou, C., Burgers, W.A., Mlisana, K., Koup, R.A., Roederer, M., Karim, S.S.A., Williamson, C. and Gray, C.M. 2014. Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. Journal of virology 88(3), 1819-1824.