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Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.

dc.contributor.authorRiou, Catherine.
dc.contributor.authorBurgers, Wendy A.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorRoederer, Mario.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorWilliamson, Carolyn.
dc.contributor.authorGray, Clive M.
dc.contributor.authorKoup, Richard A.
dc.date.accessioned2016-11-01T08:49:45Z
dc.date.available2016-11-01T08:49:45Z
dc.date.created2014
dc.date.issued2014
dc.descriptionCAPRISA, 2014.en_US
dc.description.abstractDefining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.en_US
dc.identifier.citationRiou, C., Burgers, W.A., Mlisana, K., Koup, R.A., Roederer, M., Karim, S.S.A., Williamson, C. and Gray, C.M. 2014. Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. Journal of virology 88(3), 1819-1824.en_US
dc.identifier.urihttp://dx.doi.org/10.1128/JVI.02968-13en_US
dc.identifier.urihttp://hdl.handle.net/10413/13554
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiology.en_US
dc.subjectHIV Infections/immunology.en_US
dc.subjectHIV-1/genetics.en_US
dc.subjectCohort Studies.en_US
dc.titleDifferential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.en_US
dc.typePeer reviewed journal articleen_US

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