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Browsing by Author "Tugetman, Jessica."

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    Innate antibacterial activity in female genital tract secretions is associated with increased risk of HIV acquisition.
    (Mary Ann Liebert., 2015) Pellett Madan, Rebecca.; Masson, Lindi.; Tugetman, Jessica.; Werner, Lise.; Grobler, Anna Christina.; Mlisana, Koleka Patience.; Lo, Yungtai.; Che, Denise.; Arnold, Kelly B.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.; Herold, Betsy C.
    Abstract available in pdf.
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    Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.
    (Oxford University Press on behalf of the Infectious Diseases Society of America., 2012) Dezzutti, Charlene S.; Richardson, Barbra Ann.; Marrazzo, Jeanne M.; Tugetman, Jessica.; Ramjee, Gita.; Taha, Taha E.; Chirenje, Zvavahera Mike.; Abdool Karim, Salim Safurdeen.; Hillier, Sharon Louise.; Herold, Betsy C.
    The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.