Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.
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Dezzutti, Charlene S.
Richardson, Barbra Ann.
Marrazzo, Jeanne M.
Tugetman, Jessica.
Ramjee, Gita.
Taha, Taha E.
Chirenje, Zvavahera Mike.
Abdool Karim, Salim Safurdeen.
Hillier, Sharon Louise.
Herold, Betsy C.
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Oxford University Press on behalf of the Infectious Diseases Society of America.
Abstract
The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.
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Citation
Dezzutti, C.S. et al. 2012. Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. J Infect Dis. 206 (12) pp. 1931-1935.