Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
United States National Academy of Sciences.
Abstract
Abstract available in pdf.
Description
CAPRISA, 2015.
Keywords
CCR5., HIV., T cell activation., Methylation., Polymorphism.
Citation
Gornalusse, G.G., Mummidi, S., Gaitan, A.A., Jimenez, F., Ramsuran, V., Picton, A., Rogers, K., Manoharan, M.S., Avadhanam, N., Murthy, K.K., Martinez, H., Murillo, A.M., Chykarenko, Z.A., Hutt, R., Daskalakis, D., Shostakovich-Koretskaya, L., Abdool Karim, S.S., Martin, J.N., Deeks, S.G., Hecht, F., Sinclair, E., Clark, R.A., Okulicz, J., Valentine, F.T., Martinson, N., Tiemessen, C.T., Ndung’u, T., Hunt, P.W., He, W., and Ahuja, S.K. 2015. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proceedings of the National Academy of Sciences 112(34), E4762-E4771.