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Monitoring microbicide gel use with real-time notification of the container’s opening events : results of the CAPRISA Wisebag study.

dc.contributor.authorGengiah, Tanuja Narayansamy.
dc.contributor.authorUpfold, Michele.
dc.contributor.authorNaidoo, Anushka.
dc.contributor.authorMansoor, Leila Essop.
dc.contributor.authorFeldblum, Paul J.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.date.accessioned2016-11-03T07:16:39Z
dc.date.available2016-11-03T07:16:39Z
dc.date.created2014
dc.date.issued2014
dc.descriptionCAPRISA, 2014.en_US
dc.description.abstractAccurate estimation of the effectiveness of a microbicide for HIV prevention requires valid measurement of adherence to product use. A microbicide gel applicator container (Wisebag), fitted with cell phone technology to transmit opening events and text message reminders, was developed to monitor each opening event of the container as a proxy for gel use and adherence. Ten women were enrolled in a pilot study and followed for up to 4 months. Wisebag opening (WBO) dates and times were recorded and correlated with self-reported sex acts and gel applicator returns. During the 33 monthly follow-up visits, 47.8% (77/161) of the recorded number of WBO events were concordant with the number of empty (used) applicators returned. The discrepancies were likely due to removal of more than one applicator during a single opening event. When the date and time of the WBO event data was assessed in relation to three different self-report adherence measures, agreement was fairly modest. The Wisebag was found to be acceptable as a storage container and the cell phone reminders generated were useful in supporting the dosing strategy. We recommend that the Wisebag be considered for larger scale and lengthier testing in microbicide trials.en_US
dc.identifier.citationGengiah, T.N., Upfold, M., Naidoo, A., Mansoor, L.E., Feldblum, P.J., Abdool Karim, Q. and Abdool Karim, S.S. 2014. Monitoring microbicide gel use with real-time notification of the container’s opening events: results of the CAPRISA Wisebag study. AIDS and Behavior 18(5), 833-840.en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s10461-014-0750-yen_US
dc.identifier.urihttp://hdl.handle.net/10413/13558
dc.language.isoenen_US
dc.publisherSpringer.en_US
dc.subjectAdherence.en_US
dc.subjectElectronic monitoring.en_US
dc.subjectMicrobicides.en_US
dc.subjectClinical trials.en_US
dc.subjectHIV prevention.en_US
dc.titleMonitoring microbicide gel use with real-time notification of the container’s opening events : results of the CAPRISA Wisebag study.en_US
dc.typePeer reviewed journal articleen_US

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