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A green, solvent-free one-pot synthesis of disubstituted quinolines via A3-coupling using 1 mol% FeCl3.

dc.contributor.advisorJeena, Vineet.
dc.contributor.authorNaidoo, Shivani.
dc.date.accessioned2017-02-22T11:23:24Z
dc.date.available2017-02-22T11:23:24Z
dc.date.created2016
dc.date.issued2016
dc.descriptionMaster of Science in Chemistry. University of KwaZulu-Natal, Pietermaritzburg 2016.en_US
dc.description.abstractQuinoline derivatives are important compounds due to their broad range of applications in medicinal, synthetic and industrial chemistry. However, current synthetic techniques such as the classical Skraup, Döebner-Miller, Friedländer and Pfitzinger reactions have numerous drawbacks such as the use of expensive reagents/catalysts, strong acidic conditions, long reaction times, high temperatures and the use of environmentally unfriendly solvents. As a result, the development of new synthetic routes to access quinoline derivatives is vital. One such approach is the coupling between an aldehyde, amine and alkyne, known as A3-coupling, which results in the formation of propargylamine, which has been well documented in the literature. The synthesized propargylamines have multiple reaction sites and in the presence of a Lewis acid catalyst results in the formation of quinoline derivatives.en_US
dc.identifier.urihttp://hdl.handle.net/10413/14110
dc.language.isoen_ZAen_US
dc.subjectQuinolinic acid.en_US
dc.subjectIron compounds.en_US
dc.subjectTheses -- Chemistry.en_US
dc.titleA green, solvent-free one-pot synthesis of disubstituted quinolines via A3-coupling using 1 mol% FeCl3.en_US
dc.typeThesisen_US

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