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Cytochrome p450 monooxygenase cyp139 family involved in the synthesis of secondary metabolites in mycobacterial species.

dc.contributor.advisorKarpoormath, Rajshekhar.
dc.contributor.authorSyed, Puleng Rosinah.
dc.date.accessioned2023-06-30T14:11:36Z
dc.date.available2023-06-30T14:11:36Z
dc.date.created2019
dc.date.issued2019
dc.descriptionMasters Degree. University of KwaZulu-Natal, Durban.en_US
dc.description.abstractTuberculosis (TB) is one of the top infectious diseases causing numerous human deaths in the world. Despite enormous efforts, the physiology of the causative agent, Mycobacterium tuberculosis, is still poorly understood. To contribute to better understanding the physiological capacity of these microbes, we have carried out extensive in silico analyses of the 1111 mycobacterial species genomes focusing on revealing the role of the orphan cytochrome P450 monooxygenase (CYP) CYP139 family. We have found that CYP139 members are present in 894 species belonging to three mycobacterial groups: M. tuberculosis complex (850-species), Mycobacterium avium complex (34-species), and non-tuberculosis mycobacteria (10-species), with all CYP139 members belonging to the subfamily “A”. CYP139 members have unique amino acid patterns at the CXG motif. Amino acid conservation analysis placed this family in the 8th among CYP families belonging to different biological domains and kingdoms. Biosynthetic gene cluster analyses have revealed that 92% of CYP139As might be associated with producing different secondary metabolites. Such enhanced secondary metabolic potentials with the involvement of CYP139A members might have provided mycobacterial species with advantageous traits in diverse niches competing with other microbial or viral agents, and might help these microbes infect hosts by interfering with the hosts’ metabolism and immune system.en_US
dc.identifier.urihttps://researchspace.ukzn.ac.za/handle/10413/21707
dc.language.isoenen_US
dc.subject.otherTuberculosis.en_US
dc.subject.otherDrug discovery.en_US
dc.subject.otherMycobacterium tuberculosis.en_US
dc.subject.otherGenome data mining.en_US
dc.subject.otherBiosynthetic gene clusters.en_US
dc.subject.otherHost metabolism.en_US
dc.titleCytochrome p450 monooxygenase cyp139 family involved in the synthesis of secondary metabolites in mycobacterial species.en_US
dc.typeThesisen_US

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