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Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.

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dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorSeoighe, Cathal.
dc.contributor.authorMartin, Darren Patrick.
dc.contributor.authorWood, N.
dc.contributor.authorAbrahams, Melissa-Rose.
dc.contributor.authorde Assis Rosa, Debra.
dc.contributor.authorBredell, Helba.
dc.contributor.authorWoodman, Zenda.
dc.contributor.authorHide, Winston.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorGray, Clive M.
dc.contributor.authorWilliamson, Carolyn.
dc.date.accessioned2012-11-28T07:09:34Z
dc.date.available2012-11-28T07:09:34Z
dc.date.created2009
dc.date.issued2009
dc.description.abstractIt is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential “transmission signatures”, we compared 20 full-length HIV-1 subtype C genomes from primary infections, with 66 sampled from ethnically and geographically matched individuals with chronic infections. Controlling for recombination and phylogenetic relatedness, we identified 39 sites at which amino acid frequency spectra differed significantly between groups. These sites were predominantly located within Env, Pol and Gag (14/39, 9/39 and 6/39 respectively) and were significantly clustered (33/39) within known immunoreactive peptides. Within 6 months of infection, we detected reversion-to-consensus mutations at 14 sites and potential CTL escape mutations at seven. Here we provide evidence that frequent reversion mutations probably allows the virus to recover replicative fitness which, together with immune escape driven by the HLA alleles of the new hosts, differentiate sequences from chronic infections from those sampled shortly after transmission.en
dc.identifier.citationTreurnicht, F.K. et al. 2010. Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure. Virology 396 (2), pp. 213–225.en
dc.identifier.issn0042-6822
dc.identifier.urihttp://dx.doi.org/10.1016/j.virol.2009.10.002en
dc.identifier.urihttp://hdl.handle.net/10413/8030
dc.language.isoenen
dc.publisherElsevier.en
dc.subjectHIV infections--Transmission.en
dc.subjectHIV (Viruses)--Transmission.en
dc.titleAdaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.en
dc.typeJournal articleen

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