Synthesis, characterisation and antibacterial activity of substituted 2-quinoline thiosemicarbazones.
dc.contributor.advisor | Koorbanally, Neil Anthony. | |
dc.contributor.author | Shezi, Siboniso Sibusiso. | |
dc.date.accessioned | 2020-04-07T17:26:12Z | |
dc.date.available | 2020-04-07T17:26:12Z | |
dc.date.created | 2017 | |
dc.date.issued | 2017 | |
dc.description | Masters Degree. University of KwaZulu-Natal, Durban. | en_US |
dc.description.abstract | Fifteen quinoline-2-thiosemicarbazone hybrid derivatives were synthesised in a three step reaction involving formation of the quinoline, oxidation of the 2-methyl group and condensation to the thiosemicarbazones. The phenylhydrazines were prepared in an additional step prior to the condensation. Twelve of the fifteen hybrid molecules were novel. A full structural elucidation of all synthesised compounds were carried out using amongst others 1D and 2D NMR spectroscopy and mass spectrometry. The data presented here will provide a basis for the identification of further molecules of this type. The hybrid molecules were then subjected to antibacterial bioassays against Gram -ve and Gram +ve bacterial strains. Unfortunately, only one compound, the 6-bromo-4'-fluoro derivative on the (E)-2-quinoline-2- yl)methylene-N-phenylhydrazinecarbothiamide framework showed any antibacterial activity. They were active against both Staphylococus aureus and methicillin resistant Staphylococcus aureus (MRSA) at 387 uM. | en_US |
dc.identifier.uri | https://researchspace.ukzn.ac.za/handle/10413/17767 | |
dc.language.iso | en | en_US |
dc.subject.other | Quinoline-2-thiosemicarbazone. | en_US |
dc.subject.other | Antibacterial. | en_US |
dc.subject.other | Doebner-von miller. | en_US |
dc.subject.other | Structural elucidation. | en_US |
dc.title | Synthesis, characterisation and antibacterial activity of substituted 2-quinoline thiosemicarbazones. | en_US |
dc.type | Thesis | en_US |
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