• Login
    View Item 
    •   ResearchSpace Home
    • Caprisa (Centre for the Aids programme of research in South Africa)
    • Research papers (Caprisa)
    • View Item
    •   ResearchSpace Home
    • Caprisa (Centre for the Aids programme of research in South Africa)
    • Research papers (Caprisa)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Microbicide clinical trial adherence: insights for introduction.

    Thumbnail
    View/Open
    Peer reviewed journal article (150.7Kb)
    Date
    2012
    Author
    Woodsong, Cynthia.
    MacQueen, Kathleen M.
    Amico, Kathy Rivet.
    Friedland, Barbara A.
    Gafos, Mitzy.
    Mansoor, Leila Essop.
    Tolley, Elizabeth E.
    McCormack, Sheena.
    Metadata
    Show full item record
    Abstract
    After two decades of microbicide clinical trials it remains uncertain if vaginally- delivered products will be clearly shown to reduce the risk of HIV infection in women and girls. Furthermore, a microbicide product with demonstrated clinical efficacy must be used correctly and consistently if it is to prevent infection. Information on adherence that can be gleaned from microbicide trials is relevant for future microbicide safety and efficacy trials, pre-licensure implementation trials, Phase IV post-marketing research, and microbicide introduction and delivery. Drawing primarily from data and experience that has emerged from the large-scale microbicide efficacy trials completed to-date, the paper identifies six broad areas of adherence lessons learned: (1) Adherence measurement in clinical trials, (2) Comprehension of use instructions/Instructions for use, (3) Unknown efficacy and its effect on adherence/Messages regarding effectiveness, (4) Partner influence on use, (5) Retention and continuation and (6) Generalizability of trial participants’ adherence behavior. Each is discussed, with examples provided from microbicide trials. For each of these adherence topics, recommendations are provided for using trial findings to prepare for future microbicide safety and efficacy trials, Phase IV post-marketing research, and microbicide introduction and delivery programs.
    URI
    http://dx.doi.org/10.7448/IAS.16.1.18505
    http://hdl.handle.net/10413/9991
    Collections
    • Research papers (Caprisa) [456]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisorsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisorsType

    My Account

    LoginRegister

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV