Masters Degrees (Medical Microbiology)
Recent Submissions
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The phenotypic and clinical characterisation of tigecycline coresistant carbapenem-resistant Enterobacterales observed at Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
(2021)Background Rising rates of carbapenem-resistant Enterobacterales (CRE) and limited therapeutic options have resulted in clinical dependence on tigecycline with subsequent emergence of tigecycline coresistant CRE (TGC ... -
Cytokine immune response profiles during 5 intestinal helminths and Mycobacterium 6 tuberculosis coinfection: An in vitro and human ex vivo study in KwaZulu-Natal.
(2023)Background: There is a striking geographic overlap between helminths and tuberculosis (TB), particularly in developing countries like Africa. Underprivileged communities are more susceptible to these illnesses due to ... -
The impact of point-of-care testing and treatment of sexually transmitted infections and bacterial V aginosis on the genital epithelial barrier integrity.
(2022)In sub-Saharan Africa, women and young girls suffer the highest burden of HIV infections. Inflammation at the genital tract is a factor responsible for the increased susceptibility to HIV risk in women, presumably through ... -
The Impact of vaginal microbiota on human Papillomavirus infection.
(2022)Background: Cervical human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) in sub-Saharan African women of reproductive age. While most women clear HPV infection, persistent infection ... -
The characterization of a putative DNA repair protein in Mycobacterium Tuberculosis, encoded rv2414c.
(2023)Mycobacterium tuberculosis (MTB) is a causative agent of the communicable disease tuberculosis (TB), which is regarded as one of the top ten causes of death worldwide. Globally, TB accounts for over 10 million infections ... -
Activation of silent biosynthetic gene clusters and profiling of secondary metabolites secreted by Endophytic Fungi for use as potential anti-HIV agents.
(2022)The continuous burden of Human Immunodeficiency Virus-1 in Sub-Saharan Africa, coupled with the inability of antiretroviral agents to eradicate HIV-1 from viral reservoirs, the potential risks of drug resistance development, ... -
The role of specific adhesins in the regulation of other adhesin genes associated with Mycobacterium tuberculosis pathogenicity.
(2022)Background/Aim: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains one of the most common causes of death throughout the world. The lack of rapid diagnostics, effective vaccines, and drugs ... -
Characterization of the function of RV1268c, an ATP binding cassette transporter in Mycobacterium tuberculosis.
(2023)Tuberculosis (TB) is an epidemic disease that is caused by a bacterium called Mycobacterium tuberculosis (Mtb). This disease infects and kills millions of people globally. Anti-Tuberculosis (anti-TB) drugs such as ... -
External ventricular drain infections: a retrospective analysis at a central hospital in KwaZulu-Natal, South Africa.
(2022)Objectives We describe clinical, laboratory and microbiological characteristics of patients with suspected EVD-related infections (EVDRIs), colonisation and contamination. Methods An observational analytical retrospective ... -
Characterizing the function of the Rv3218 gene in Mycobacterium tuberculosis.
(2023)Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a primordial affliction that continues to torment humankind since its known history and prehistory. TB is among the major causes of ill-health and death in the ... -
Impact of Chlamydia trachomatis on inhibitory capabilities of broadly neutralizing antibodies in vitro.
(2021)Abstract available in PDF. -
Microbial profile and antimicrobial susceptibility patterns of neonatal blood stream infections in Durban, South Africa.
(2020)Objectives Antimicrobial resistance (AMR) has emerged as a global threat to healthcare resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third highest cause of neonatal demise globally, ... -
Molecular epidemiology of antibiotic resistant salmonella spp. from farm to fork in an intensive pig production system in KwaZulu-Natal South Africa.
(2021)Antibiotic resistance (ABR) is a worldwide challenge, and, if not resolved, can be a danger to humans, animals and the ecosystem. The inappropriate use and misuse of antibiotics in food animal production creates selection ... -
Defining the role of high-dose isoniazid in the treatment of multi-drug resistance tuberculosis: isoniazid resistant profiling.
(2021)Background: High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (MDR-TB). However, there is no substantial evidence supporting its use in the presence of INH resistant mutations. ... -
The role of Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) on global in vitro bacterial transcriptomics.
(2021)Background/Aim: Tuberculosis (TB), is an infectious, airborne disease caused by Mycobacterium tuberculosis (M. tuberculosis). TB remains one of the most devastating bacterial causes of human mortality, especially in ... -
Fosfomycin: an oral treatment option for multi drug resistant uropathogens.
(2021)Introduction Urinary tract infections (UTIs) are commonplace in both the community and hospital environment where it is accepted clinical practice to treat empirically. Consequently, this has led to an alarming increase ... -
Molecular surveillance of Staphylococcus aureus on frequently touched sites in public hospitals in KwaZulu-Natal, South Africa.
(2021)There is an escalation in the prevalence of hospital-acquired infections (HAI) due to the transfer of pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), within the hospital environment. Pathogens ... -
Distribution, virulence and antimicrobial resistance profile of Bacillus species from the environment of four public hospitals in South Africa.
(2021)Hospital-acquired infections (HAIs) are counted as the most crucial global health crisis. The hospital environment may be colonized by opportunistic pathogens, which can lead to HAIs in hospitalized patients. As a result, ... -
Characterization of immunoglobulin (Ig) isotypes, IgG subclasses and cytokines in the blood and genital tracts of HIV infected and healthy women from an observational cohort study (CAPRISA 082)
(2020)Background: Heterosexual transmission remains the dominant route of HIV infections in women. Immune responses that predict HIV acquisition during pre-exposure prophylaxis (PrEP) remain undefined. We hypothesized that ...
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