Determinants of optimal adherence over time to antiretroviral therapy amongst HIV positive adults in South Africa : a longitudinal study.
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Verlag.
Abstract
Highly active antiretroviral therapy (HAART) requires strict adherence to achieve optimal clinical
and survival benefits. A study was done to explore the factors affecting HAART adherence among
HIV positive adults by reviewing routinely collected patient information in the Centre for the
AIDS Programme of Research in South Africa’s (CAPRISA) AIDS Treatment Programme.
Records of 688 patients enrolled between 2004 and 2006 were analysed. Patients were considered
adherent if they had taken at least 95% of their prescribed drugs. Generalized estimating equations
were used to analyse the data. The results showed that HAART adherence increased over time,
however, the rate of increase differed by some of the socio-demographic and behavioural
characteristics of the patients. For instance, HAART adherence increased in both urban and rural
treatment sites over time, but the rate of increase was higher in the rural site. This helped identify
sub-populations, such as the urban population, that required ongoing adherence counseling.
Description
Keywords
Highly active antiretroviral therapy., HIV infections-Drug therapy., Patient compliance., Longitudinal method.
Citation
Published in final edited form as: Maqutu, D., et al. 2011. Determinants of optimal adherence over time to antiretroviral therapy amongst HIV positive adults in South Africa : a longitudinal study. AIDS Behav. 15 (7) pp. 1465–1474.