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Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa.

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Authors

Loveday, Marian Patricia.
Wallengren, Kristina.
Voce, Anna Silvia.
Margot, Bruce.
Reddy, T.
Master, Iqbal.
Brust, James C. M.
Chaiyachati, K.
Padayatchi, Nesri.

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International Union against Tuberculosis and Lung Disease.

Abstract

Setting—In KwaZulu-Natal, South Africa, a TB and HIV endemic setting, prolonged hospitalisation for the treatment of the growing number of MDR-TB patients is not possible or effective. Objective—We compared early treatment outcomes in patients with MDR-TB, with and without HIV co infection, at a central, urban, referral hospital with four decentralised rural sites. Design—This is an operational, prospective cohort study of patients between 1 July 2008 to 30 November 2009, where culture conversion, time-to-culture-conversion, survival and predictors of these outcomes were analysed. Results—Of the 860 patients with MDR-TB, 419 were at the decentralised sites and 441 at the central hospital. Overall, 71% were HIV co-infected.

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Citation

Loveday, M. et al. 2012. Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 16(2) pp. 209–215.