Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa.
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Date
Authors
Loveday, Marian Patricia.
Wallengren, Kristina.
Voce, Anna Silvia.
Margot, Bruce.
Reddy, T.
Master, Iqbal.
Brust, James C. M.
Chaiyachati, K.
Padayatchi, Nesri.
Journal Title
Journal ISSN
Volume Title
Publisher
International Union against Tuberculosis and Lung Disease.
Abstract
Setting—In KwaZulu-Natal, South Africa, a TB and HIV endemic setting, prolonged hospitalisation for the treatment of the growing number of MDR-TB patients is not possible or effective.
Objective—We compared early treatment outcomes in patients with MDR-TB, with and without HIV co infection, at a central, urban, referral hospital with four decentralised rural sites.
Design—This is an operational, prospective cohort study of patients between 1 July 2008 to 30 November 2009, where culture conversion, time-to-culture-conversion, survival and predictors of these outcomes were analysed.
Results—Of the 860 patients with MDR-TB, 419 were at the decentralised sites and 441 at the central hospital. Overall, 71% were HIV co-infected.
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Citation
Loveday, M. et al. 2012. Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 16(2) pp. 209–215.