• Login
    View Item 
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Health Sciences
    • Pharmaceutical Sciences
    • Masters Degrees (Pharmaceutical Sciences)
    • View Item
    •   ResearchSpace Home
    • College of Health Sciences
    • School of Health Sciences
    • Pharmaceutical Sciences
    • Masters Degrees (Pharmaceutical Sciences)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Pharmaceutical availability on newly formulated oral sustained release pellets containing the antihistamine, chlorpheniramine maleate.

    Thumbnail
    View/Open
    Thesis (9.465Mb)
    Date
    1991
    Author
    Mathir, Zohra Mohamed.
    Metadata
    Show full item record
    Abstract
    The main objective of the present study was to determine the feasibility of obtaining aqueous polymer-coated pellet formulations using EudragitR NE 30 D dispersion and chlorpheniramine maleate as the model drug. Many factors influence the rate of drug release from coated beads including, the substrate, the coating formulation and the coating process. A drug release profile that was comparable to that of the reference standard, DykatussR Capsules was obtained with a formulation employing 8.3% EudragitR NE 30 D, 0.5% talc and 1% polyethylene glycol. In vitro dissolution tests on this formulation showed drug release to be predictable, reproducible and independent of the dissolution methods or media. Short term storage confirmed the stability at room temperature (20°C) and low temperature (5C). Scanning electron micrographs of pellets stored at elevated temperatures i.e. 37°C with 80% relative humidity and 40°C illustrated the phenomenon of 'further gradual coalescence' which corresponded to the decrease in release of drug from the pellets.
    URI
    http://hdl.handle.net/10413/8017
    Collections
    • Masters Degrees (Pharmaceutical Sciences) [110]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisorsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisorsType

    My Account

    LoginRegister

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV