Masters Degrees (Biochemistry)
Recent Submissions
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The stabilisation of the cysteine protease of Carica papaya (papain) and the catalytic domain of the Cathepsin L-like cysteine protease of Trypanosoma congolense (TcoCATL)
(2019)Proteases play an intricate role in the numerous functions of a living organism. Proteases are responsible for the cleavage of proteins into smaller fragments by catalysing the hydrolysis of peptide bonds. The class of ... -
Transferrin receptor-mediated gene delivery using functionalised gold nanoparticles.
(2018)Gene therapy strategies have shown their potential in treating numerous central nervous system (CNS) disorders, including highly aggressive brain cancers. Gold nanoparticles (AuNPs) are popular vectors for gene delivery, ... -
Expression and evaluation of a 297-amino acid fragment of the blood stage protein PfC0760c from Plasmodium falciparum.
(2019)Abstract available in pdf. -
Evaluating the effect of nitric oxide on myoblast proliferation, migration and differentiation.
(2018)Wound healing is the process of restoring tissue integrity in response to injury. This process involves four major phases namely; haemostasis, inflammation, regeneration and remodelling. These phases are regulated by ... -
Mechanisms behind the anti-diabetic effects of caffeine in a Type 2 diabetes model of rats.
(2018)Caffeine has been used for many years and is one of the most extensively consumed active food ingredient throughout the world. Caffeine has been broadly studied in a variety of areas regarding human health and performance. ... -
Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
(2018)Emerging drug resistance hinders the efforts to control malaria and so novel antimalarial drugs are required. Copper is essential for the survival of plasmodial parasites but the proteins involved in copper homeostasis are ... -
Recombinant expression, purification, analysis and immunization of mice with plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase (rPyGAPDH) and lactate dehydrogenase (rPyLDH) and evaluation of protection against P. berghei challenge.
(2019)The principal focus in malaria research is the development of an effective malaria vaccine which will help to prevent death and eliminate the disease. This study investigated two plasmodial glycolytic enzymes as possible ... -
The impact of aromatic ring count on the bioavailability of chemical compounds.
(2019)Aromatic rings are a negative contributing factor in the bioavailability of chemical compounds in drug discovery. Due to the inevitable effect the aromatic rings possess on the bioavailability of chemical compounds, methods ... -
Development of a novel biochemical assay for the identification of promiscuous compounds.
(2019)Promiscuous compounds, specifically aggregate-based inhibitors that result in false positives in biochemical activity assays present a serious and increasing interference to early-stage drug discovery processes. Although ... -
The evaluation of novel metal -based compounds as potential BACE1 ligands.
(2018)The proposed primary cause of Alzheimer’s disease (AD) is the cleavage of the Amyloid-β precursor protein by the β- Amyloid cleavage enzyme 1 (BACE1). As such it has been proposed that inhibiting this enzyme would help ... -
Antiplasmodial activity of Warburgia salutaris (Bertol. F.) Chiov. (Cannelaceae).
(2017)Abstract available in PDF file. -
Recombinant expression optimisation and characterisation of peptidases for diagnosis of animal African Trypanosomosis.
(2018)Abstract available in PDF file. -
Silver nanoparticles from biological extracts and their antimicrobial activities.
(2017)The increasing incidence of multi-drug resistant organisms has led to the resurgence in application of Ag-based compounds. Accordingly, increased efforts have been made in the field of nanotechnology to develop silver ... -
Identification of infectious bursal disease virus (IBDV) receptors through the use of recombinant capsid protein, VP2.
(2014)Infectious bursal disease virus (IBDV) is a non-enveloped Birnavirus which infects the immature antibody producing B-cells of the bursa of Fabricius in young chickens. The virus causes infectious bursal disease (IBD) which ... -
Antidiabetic activity of Warburgia salutaris (Bertol. f.) Chiov. (Canellaceae).
(2017)Abstract available in PDF file. -
A novel in vitro anticancer drug delivery strategy using platinum encapsulated gold nanoparticles.
(2017)Abstract available in PDF file. -
Recombinant expression and bioinformatic analysis of plasmodium falciparum lactate dehydrogenase and heat shock protein 70-1.
(2017)Malaria remains a serious human health problem and the disease is particularly prevalent in developing countries. Malaria is caused by a parasite of the genus Plasmodium. Diagnosis of malaria is required before any treatment ... -
The application of layered double hydroxide nanoparticles (LDHs) as potential anticancer drug delivery systems.
(2016)Chemotherapy being one of the principle techniques used in cancer treatment, has been applied in the treatment of a wide spectrum of cancers. However, this mode of treatment is fraught with a myriad of challenges, reducing ...
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