Doctoral Degrees (Physiology)
Recent Submissions
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The effect of isolated and nanoencapsulated flavonoids from Eriocephalus africanus on apoptotic factors and microRNA expression in cancer.
(2020)Cancer continues to be a major health burden worldwide, with millions of new cases being diagnosed each year. Among women breast cancer remains a leading cause of cancer-related morbidity and mortality globally, despite ... -
Evaluation of the therapeutic properties of a Ruthenium(ll) uracil-derived diimine complex on selected complications associated with diet-induced pre-diabetes.
(2019)Pre-diabetes is a chronic metabolic condition where blood glucose levels are above the upper threshold considered normal but below the threshold for a diagnosis of diabetes. Pre-diabetes predisposes individuals to a high ... -
Evaluating immune activation and cellular determinants of thrombosis in pre-diabetes.
(2018)Introduction Platelet dysregulation in pre-diabetes plays a major role in the progression of prothrombotic and pro-inflammatory conditions. Cardiovascular disease (CVD), which may occur at the pre-diabetic stage, are a ... -
Investigating the effects of bredemolic acid on selected markers of some prediabetes-associated dysfunctions in diet-induced prediabetic rats.
(2019)Prediabetes is an abnormal glycaemic state between normoglycaemia and chronic hyperglycaemia which is currently prevalent in developing and developed countries due to increased consumption of high caloric diet coupled with ... -
Investigating the biomarker potential of exosomes in preeclampsia.
(2019)Preeclampsia is a hypertensive disorder of pregnancy and one of the leading causes of maternal and perinatal morbidity, affecting up to 7 -10% of pregnancies globally which results in 50 000-76 000 maternal deaths per year ... -
The cytotoxic effects, anti-iflammatory, antioxidant, antibacterial, and antidiabetic properties of eight selected South African plants for medicinal purposes.
(2020)People from the Southern African region have been using the fauna and flora of the region in their homes for millennia to treat all sorts of ailments and complaints with great success. This knowledge transfer was done ... -
An evaluation of the chemical composition and the in vitro and in vivo antihypertensive activity of extracts of Tulbaghia acutiloba Harv. in an L-NAME induced hypertensive model.
(2019)The increasing prevalence of hypertension over the years has been identified as a major contributor to high morbidity and mortality, globally and locally, in Africa, posing a serious global health threat. The demand for ... -
Fungal endophytes: isolation, identification and assessment of bioactive potential of their natural products.
(2017)Fungal endophytes produce a broad variety of bioactive compounds with potential to address some of the unmet human needs. Medicinal plants have an important role to play in the search for new strains of endophytes ... -
Insulin resistance and salt sensitivity in the rat model of hypertension
(2002)Abstract available in PDF file. -
An EM investigation of skeletal muscle regeneration in cultured explants.
(1995)Abstract available in PDF file. -
Monitoring the change in health behaviour of learners in selected health promoting schools in KwaZulu-Natal.
(2009)Abstract available in PDF file. -
Mechanisms of the cardiovascular effects of some medicinal plants : an experimental study.
(2008)Abstract available in PDF file. -
Effects of maslimic acid and related triterpene derivatives on kidney function of male Sprague-Dawley rats.
(2014)Reports indicate that hyperglycaemia leads to development of kidney complications which result in sodium retention, decrease in glomerular filtration rate (GFR) and high blood pressure. Various biochemical processes such ... -
Transdermal delivery of insulin and Syzygium aromaticum-derived oleanolic acid by dermal patches in streptozotocin-induced diabetic rats : effects on some selected metabolic parameters.
(2014)The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus often requires numerous daily injections of bolus insulin. Typically insulin is administered by subcutaneous needle ... -
Syzygium aromaticum-derived triterpenes modulate intestinal glucose handling in streptozotocin-induced diabetic rats.
(2014)Polyphagia in diabetes mellitus ascribed to elevated plasma ghrelin concentrations is associated with prolonged postprandial hyperglycaemia due to increased activities of intestinal carbohydrate hydrolyzing enzymes and ... -
Mechanisms of cardiovascular effects of oleanolic acid and related synthetic oleanane derivatives : an experimental study.
(2014)Introduction Despite the various conventional treatments that are available to treat hypertension, this disease continues to be globally responsible for approximately 9.4 million deaths each year. The high mortality can ... -
The effects of insulin and Syzygium aromaticum-derived oleanolic acid containing dermal patches on kidney function and renal expression of glucose transporters in streptozotocin-induced diabetic rats.
(2014)Introduction The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus requires multiple daily injections of bolus insulin which have been reported to be associated with Na+ ... -
The role of antioxidants in atherogenesis and salt-sensitive hypertension.
(2003)Abstract available in PDF file. -
Hypoglycaemic effects of some medicinal plant extracts in streptozotocin-induced diabetic rats.
(2007)Abstract available in PDF file. -
Immunohistochemical and ultrastructural evaluation of the pathology and aetiopathogenesis of keloid formation.
(2013)Introduction Keloids are formed by the excessive production of scar tissue, which extends beyond the margins of the original injury, often resulting in lesions of grotesque dimensions. Keloids present a major dilemma ...
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