Doctoral Degrees (Physiology)
Recent Submissions
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Fungal endophytes: isolation, identification and assessment of bioactive potential of their natural products.
(2017)Fungal endophytes produce a broad variety of bioactive compounds with potential to address some of the unmet human needs. Medicinal plants have an important role to play in the search for new strains of endophytes ... -
Insulin resistance and salt sensitivity in the rat model of hypertension
(2002)Abstract available in PDF file. -
An EM investigation of skeletal muscle regeneration in cultured explants.
(1995)Abstract available in PDF file. -
Monitoring the change in health behaviour of learners in selected health promoting schools in KwaZulu-Natal.
(2009)Abstract available in PDF file. -
Mechanisms of the cardiovascular effects of some medicinal plants : an experimental study.
(2008)Abstract available in PDF file. -
Effects of maslimic acid and related triterpene derivatives on kidney function of male Sprague-Dawley rats.
(2014)Reports indicate that hyperglycaemia leads to development of kidney complications which result in sodium retention, decrease in glomerular filtration rate (GFR) and high blood pressure. Various biochemical processes such ... -
Transdermal delivery of insulin and Syzygium aromaticum-derived oleanolic acid by dermal patches in streptozotocin-induced diabetic rats : effects on some selected metabolic parameters.
(2014)The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus often requires numerous daily injections of bolus insulin. Typically insulin is administered by subcutaneous needle ... -
Syzygium aromaticum-derived triterpenes modulate intestinal glucose handling in streptozotocin-induced diabetic rats.
(2014)Polyphagia in diabetes mellitus ascribed to elevated plasma ghrelin concentrations is associated with prolonged postprandial hyperglycaemia due to increased activities of intestinal carbohydrate hydrolyzing enzymes and ... -
Mechanisms of cardiovascular effects of oleanolic acid and related synthetic oleanane derivatives : an experimental study.
(2014)Introduction Despite the various conventional treatments that are available to treat hypertension, this disease continues to be globally responsible for approximately 9.4 million deaths each year. The high mortality can ... -
The effects of insulin and Syzygium aromaticum-derived oleanolic acid containing dermal patches on kidney function and renal expression of glucose transporters in streptozotocin-induced diabetic rats.
(2014)Introduction The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus requires multiple daily injections of bolus insulin which have been reported to be associated with Na+ ... -
The role of antioxidants in atherogenesis and salt-sensitive hypertension.
(2003)Abstract available in PDF file. -
Hypoglycaemic effects of some medicinal plant extracts in streptozotocin-induced diabetic rats.
(2007)Abstract available in PDF file. -
Immunohistochemical and ultrastructural evaluation of the pathology and aetiopathogenesis of keloid formation.
(2013)Introduction Keloids are formed by the excessive production of scar tissue, which extends beyond the margins of the original injury, often resulting in lesions of grotesque dimensions. Keloids present a major dilemma ... -
The effect of sildenafil citrate and kraussianone-2 on pre-eclampsia-like manifestations in Sprague-Dawley rats.
(2011)Pre-eclampsia, often described as toxaemia of pregnancy, historically represents one of the most widely investigated conditions relating to human reproduction. To date no firm cure has been found and a clear, well defined ... -
The value of morphological analysis in duodenal ulcer therapy
(1994)This study was designed to examine two premises: that the morphological "severity" of duodenal ulcers (DU) may influence the incidence of drug mediated healing and the morphological "quality" of healing after curative ... -
Endotoxaemia in intestinal dysfunction in experimental animals : intestinal ischaemia and hyperthermia.
(1988)Endotoxins or lipopolysaccharides (LPS), highly toxic component of the outer membrane of gram-negative bacteria, are normally present in the mammalian gut lumen.In this thesis, I investigated, in laboratory animals, whether ... -
The synthesis of xanthone derivatives and their enzymatic conversion and inhibition of aflatoxin biosynthesis.
(1996)The biosynthesis of Aflatoxin B1 (AFB1) has been the subject of conflicting speculation and numerous reviews. The currently accepted scheme for the aflatoxin pathway is based on data obtained from feeding studies using ... -
The possible implication of selected Fusarium Mycotoxins in the aetiology of brain cancer.
(2004)The central nervous system is a potential site of action for the Fusarium mycotoxin Fumonisin B1 (FB1), and is exemplified in horses by the disease equine leukoencephalomalacia. Structurally resembling sphingoid bases, FB1 ... -
Chemical investigation of isihlambezo or traditional pregnancy-related medicines.
(2004)This study was undertaken to redress the scant knowledge regarding the chemistry and mode of action of pregnancy-related traditional medicines, or isihlambezo (Zulu), which are used by 60 to 80% of women in South Africa. ... -
The role of angiotensin ll and oxidative stress in the spontaneously hypertensive rat.
(2011)Oxidative stress resulting from an imbalance between free radicals and antioxidants is considered to be an important etiological factor in the development and maintenance of hypertension. Angiotensin II (Ang II) has been ...
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