Physiology
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Investigating the association between diet-induced “leaky gut” and the development of prediabetes.
(2023)Introduction Type 2 diabetes (T2D) is the most common type of diabetes mellitus, which is reported to be associated with life-threatening co-morbidities. This condition is characterized by hyperglycaemia due to a defect of ... -
The association between incretin hormones concentrations and the development of diet-induced Prediabetes.
(2023)The increase in the prevalence of type two diabetes mellitus(T2DM) is attributed to unhealthy lifestyles and high-calorie diets. T2DM is a chronic metabolic condition characterised by impaired insulin function and high ... -
Investigating Genetic Predisposition to Gestational Diabetes Mellitus Among Black Women Residing eThekwini, KwaZulu-Natal, South Africa.
(2023)Gestational Diabetes Mellitus (GDM) is regarded as a “silent killer” determined by an abnormal glucose tolerance firstly recognised at any time during pregnancy and disappear after delivery. Carrying a large baby (>4000g), ... -
The influences of paternal prenatal chronic stress on offspring selected metabolic, behavioural and neurochemistry changes.
(2022)Exposure to past stress and trauma during early developmental stages can permanently affect the performance and advancements of core systems in humans. Whilst many studies are investigating the lasting effects of maternal ... -
Respiratory patterns and cytokine profiles among recreational athletes and a sedentary group.
(2021)Background: An increasing trend in sedentary lifestyles and physical inactivity has contributed to a higher incidence of obesity, a major health concern. Despite the fact that a sedentary lifestyle poses a considerable ... -
The experiences and social factors influencing the behavior of incarcerated rapists in a male prison in KwaZulu-Natal, South Africa.
(2022)Introduction: South Africa is amongst the leading countries in the world to record high rate of sexual violence against women and children. South Africa has been labelled “the rape capital of the world” with 116 rape ... -
The role of neuroinflammation, serotonin deficiency and gene expression in the pathology of L-dopa-induced dyskinesia with prolonged Levodopa treatment in a Parkinsonian rat model.
(2023)Parkinson’s disease (PD) is a neurodegenerative disorder, which globally affects 2% of the population above 65 years old. It is characterized by motor symptoms (bradykinesia, tremor, and rigidity) and nonmotor symptoms ... -
Investigating platelet and endothelial activation in ART-treated women living with HIV and obesity.
(2022)Background: Antiretroviral therapy (ART) has reduced morbidity and mortality in people living with Human immunodeficiency virus (PLWH). However, metabolic and thrombotic complications have now become prevalent in the ... -
Alzheimer’s disease dementia risk in post-traumatic stress disorder: identification of common underlying mechanisms using rat models.
(2021)Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that can develop from exposure to a trauma. Studies have shown that people who have PTSD are susceptible to developing dementia, mostly Alzheimer’s ... -
Investigating markers of T-Cell activation due to chronic inflammation in Type 2 Diabetes.
(2020)Background: Type 2 diabetes (T2D) is amongst the leading causes of mortality associated with non-communicable diseases. Insulin resistance, low-grade chronic inflammation, together with T cell activation, play an essential ... -
Effects of moderate treadmill activity on cardiovascular factors in spontaneously hypertensive rats.
(2016)Hypertension is a major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular disease. Oxidative stress due to either increase of reactive oxygen species ... -
Effect of titanium dioxide nanoparticle aggregation on mouse myoblast cellular cytotoxicity and nitric oxide synthesis.
(2017)ABSTRACT Introduction: The emerging interest of engineered titanium dioxide nanoparticles (TiO2 NPs) in medical, agricultural, industrial and manufacturing sectors have raised health questions worldwide. Therefore, the ... -
Evaluating plasmodium berghei infection influence and asiaticacid administration efficacy in sprague dawley male rats: effects on parasitamia, glucose homeostasis and renal electrolyte handling.
(2016)Abstract Introduction: Five human-infecting Plasmodium species orchestrate varied pathophysiology culminating in malaria. Despite being treatable, malaria has high mortality and morbidity in pregnant women and children ... -
The effects of multivitamin-multimineral supplementation on the spontaneously hypertensive rat model of hypertension.
(2015)ABSTRACT The nutraceutical industry has proliferated in recent years with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has ... -
Developmental methylmercury toxicity in a 6- hydroxydopamine Parkinsonian rat model: evaluating Searsia chirindensis as a potential neuroprotectant.
(2017)Methylmercury (MeHg) pollution in South Africa has escalated due to increased demand from industrial sources such as coal-fired power stations. This had led to a growing interest in the effects of this metal toxin on ... -
Characterising epigenetic alterations following cocaine consumption.
(2017)Complementary data from clinical and animal research have converged on the hypothesis that persistent use of psychostimulant drugs such as cocaine may not only involve pathological alterations in neural processes that ... -
Comparison of the effects of oral and transdermal adminstration of chloroquine on selected haematological parameters and inflammatory cytokines in P.berghei- infected male Sprague-Dawley rats.
(2016)Introduction Chloroquine (CHQ), the mainstay antimalarial drug accumulates in organs and alters physiological function. Hypoglycaemia, impairment of kidney function and anaemia are among an array of pathophysiological ... -
T cell function and immune checkpoint inhibition in chronic lymphocytic leukaemia.
(2021)Background: The global burden of lymphoid malignancies gradually increased over the past decade, with chronic lymphocytic leukaemia (CLL) accounting for a quarter of the burden of all haematological malignancies. ... -
The effect of prenatal Mycobacterium tuberculosis infection on offspring neurodevelopment and autistic-like behaviours in a valproic acid mouse model of autism.
(2021)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted repetitive patterns, communication challenges and lack of social skills. ASD has no distinct biomarkers, with symptoms overlapping ... -
The acute effects of dioxidovanadium on blood glucose concentration and oxidative stress in the hippocampus of non-diabetic male Sprague Dawley rats and the chronic effects of dioxidovanadium on selected markers associated with hippocampal dysfunction in male streptozotocin-induced diabetic rats.
(2022)Diabetes mellitus is a disease associated with derangements in glucose metabolism and chronic hyperglycaemia. Chronic hyperglycaemia induces oxidative stress and inflammation that affect glucose sensitive hippocampal neurons ...
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