Physiology
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HIV-1 transactivator of transcription (TAT) protein causes neurotoxicity via astrocyte activation.
(2015)HIV is most well-known for its negative effects on the immune system and the resulting development of AIDS, however it also has severe damaging effects on the central nervous system. Many infected individuals exhibit ... -
Prenatal stress and febrile seizures effects on the epigenetic mechanisms involved in cognitive function following treatment with Searsia chirindensis.
(2016)Febrile seizures are of growing concern in the health fraternity within the African continent. These seizures predominantly affect children between the ages of 3 months and 5 years of age. Stress during pregnancy may ... -
The efficacy of manual versus local vibratory massage in promoting recovery from post-exercise muscle damage - a systematic review.
(2016)Background. It is well established that unaccustomed activity/exercise with a large eccentric component causes the development of muscle damage which results in soreness and a decline in the functional capacity of muscle. ... -
Insulin resistance and salt sensitivity in the rat model of hypertension
(2002)Abstract available in PDF file. -
An EM investigation of skeletal muscle regeneration in cultured explants.
(1995)Abstract available in PDF file. -
Monitoring the change in health behaviour of learners in selected health promoting schools in KwaZulu-Natal.
(2009)Abstract available in PDF file. -
Mechanisms of the cardiovascular effects of some medicinal plants : an experimental study.
(2008)Abstract available in PDF file. -
Evaluation of the efficacy of maslinic acid on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats : effects on blood glucose and renal fluid and electrolyte handling.
(2014)Introduction Malaria remains a major socio-economic burden in Africa despite the numerous global efforts to control and manage the disease through prevention and drug intervention. Clinical studies have shown that malaria ... -
Effect of highly active antiretroviral therapy (HAART) on HIV-1 tat protein-induced neurotoxicity.
(2014)Background: HIV-1-trans-activating (Tat) protein has been associated with development of HIVassociated neurocognitive disorder (HAND). Previous studies have demonstrated that Tat protein causes neurotoxicity through an ... -
Contractile effects of Gunnera perpensa and Rhoicissus tridentata bioactive extracts in isolated rat uterine muscles.
(2014)Abstract available in PDF file. -
Exercise and type 2 diabetes mellitus : peripheral sensory neuropathy in humans and regulation of blood glucose control in rodents.
(2015-10-16)PART ONE A prospective cohort study was conducted on eight previously inactive diabetic volunteers (34 – 47 yr) with a mean pre-trial HbA1c of 7.45 (±1.34) %, who completed an 8-week endurance exercise intervention of ... -
The effects of oxidovanadium complexes on glucose metabolism in liver and skeletal muscle cell lines.
(2014)Abstract available in PDF file. -
Effects of maslimic acid and related triterpene derivatives on kidney function of male Sprague-Dawley rats.
(2014)Reports indicate that hyperglycaemia leads to development of kidney complications which result in sodium retention, decrease in glomerular filtration rate (GFR) and high blood pressure. Various biochemical processes such ... -
Tat protein induced neurocognitive dysfunction.
(2013)Human immunodeficiency virus type 1 (HIV-1) is a major health threat in South Africa. Studies have shown that HIV affects the central nervous system (CNS), and can initiate a progressive neurodegenerative process culminating ... -
Evaluation of the efficacy of transdermal delivery of chloroquine on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats : effects on blood glucose and renal electrolyte handling.
(2013)Malaria remains a leading cause of morbidity and mortality in tropical regions of the world despite the numerous global efforts to control and manage the disease through prevention and drug intervention. An estimated 300–500 ... -
Evaluation of the efficacy of Syzygium aromaticum-derived Oleanolic acid on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats and effects on blood glucose and renal electrolyte handling.
(2015-09-04)Introduction Malaria continues to be one of the major causes of morbidity and mortality worldwide even though the disease is treatable. This is as a result of malaria parasites developing resistance to current antimalarial ... -
Evaluating a new drug to combat alzheimer's disease.
(2014)Alzheimer’s disease (AD), a progressive neurodegenerative disorder that affects mostly the limbic system and the neocortical areas of the brain, is the most prevalent form of dementia affecting the elderly population. ... -
The optimisation of a preeclampsia-like L-NAME rat model : a focus on utero-placental dysfunction.
(2014)Preeclampsia is a multi-system pregnancy syndrome characterized by the sudden onset of hypertension, escalated proteinuria and in some cases oedema usually after 20 weeks of gestation. Preeclampsia is further categorized ... -
Transdermal delivery of insulin and Syzygium aromaticum-derived oleanolic acid by dermal patches in streptozotocin-induced diabetic rats : effects on some selected metabolic parameters.
(2014)The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus often requires numerous daily injections of bolus insulin. Typically insulin is administered by subcutaneous needle ... -
Syzygium aromaticum-derived triterpenes modulate intestinal glucose handling in streptozotocin-induced diabetic rats.
(2014)Polyphagia in diabetes mellitus ascribed to elevated plasma ghrelin concentrations is associated with prolonged postprandial hyperglycaemia due to increased activities of intestinal carbohydrate hydrolyzing enzymes and ...
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