Biotechnology
Recent Submissions
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The stabilisation of the cysteine protease of Carica papaya (papain) and the catalytic domain of the Cathepsin L-like cysteine protease of Trypanosoma congolense (TcoCATL)
(2019)Proteases play an intricate role in the numerous functions of a living organism. Proteases are responsible for the cleavage of proteins into smaller fragments by catalysing the hydrolysis of peptide bonds. The class of ... -
Investigation of multiple concurrent Human papillomavirus infections, oncogenicity, and STI co-infection as risk factors for Human immunodeficiency virus infection.
(2017)Background: Human papillomavirus (HPV) is one of the most common sexually transmitted infections (STIs) globally and a necessary factor for cervical cancer development. While HPV infection has been associated with increased ... -
Transferrin receptor-mediated gene delivery using functionalised gold nanoparticles.
(2018)Gene therapy strategies have shown their potential in treating numerous central nervous system (CNS) disorders, including highly aggressive brain cancers. Gold nanoparticles (AuNPs) are popular vectors for gene delivery, ... -
Synthesis, detection and quantification of inulooligosaccharides and fructooligosaccharides by extracellular and intracellular inulinase and fructosyltransferase enzymes isolated from coprophilous fungi.
(2018)Exploration of fungal biodiversity capable of producing fructosyltransferase and inulinase enzymes in significant amounts is crucial for the production of oligofructans. Indigenous coprophilous fungi are predominantly ... -
Study on Fusarium toxins contamination of cereal grains in Jiangsu Province, China.
(2018)Jiangsu Province is located in the transition zone from subtropical to warm temperate zone, with the characteristics of monsoon climate. The province's natural ecological conditions are suitable for the production of winter ... -
Treatment of lipid-rich wastewater using free and immobilized bioemulsifier and hydrolytic enzymes from indigenous bacterial isolates.
(2017)The production and discharge of raw and poorly treated lipid-rich wastewater increase yearly due to rapid urbanization and industrial growth. This results in severe environmental and health hazards by affecting the normal ... -
Quantification of time-dependent redox signalling in the Tpx1/Pap1 pathway in Schizosaccharomyces pombe.
(2019)Reactive oxygen species (ROS) can damage cellular components leading to cell death, but paradoxically, ROS also play essential roles in metabolism and signalling in eukaryotic cells. Dysregulation of this balance is ... -
Isolation and evaluation of autochthonous microalgae strains for biodiesel production and wastewater treatment.
(2018)The current depletion of global fossil fuel reserves and increasing CO2 emission are generating global climate change concerns hence, the increasing calls for the development of renewable biofuels with low CO2 emission. ... -
Methylation profiling and validation of candidate tDMRs for identification of human blood, saliva, semen and vaginal fluid and its application in forensics.
(2017)Identification of body fluids and tissues is an essential step in forensic investigation because it can be used as strong evidence in identifying suspects and victims. Currently in forensic investigations, catalytic, ... -
Expression and evaluation of a 297-amino acid fragment of the blood stage protein PfC0760c from Plasmodium falciparum.
(2019)Abstract available in pdf. -
Evaluating the effect of nitric oxide on myoblast proliferation, migration and differentiation.
(2018)Wound healing is the process of restoring tissue integrity in response to injury. This process involves four major phases namely; haemostasis, inflammation, regeneration and remodelling. These phases are regulated by ... -
Mechanisms behind the anti-diabetic effects of caffeine in a Type 2 diabetes model of rats.
(2018)Caffeine has been used for many years and is one of the most extensively consumed active food ingredient throughout the world. Caffeine has been broadly studied in a variety of areas regarding human health and performance. ... -
The endosymbiotic bacteria of the South African bird cherry-oat aphid, rhopalosiphum padi.
(2018)Cereal crops play a major role in human diet as staple foods, especially in developing countries. These crops are a part of a few edible crops that are widely cultivated globally. However, the production of these crops is ... -
Genetic characterization of resistance and virulence genes in Enterococcus species from animal isolates in Durban.
(2018)Misuse of antimicrobials in animal agriculture has given rise to strains of bacteria that are resistant to multiple antibiotics. Enterococci bacteria have emerged among such antibiotic-resistant strains of bacteria and ... -
Investigating the quorum-sensing inhibitory and potential HIV activity of indigenous South African sponge-associated bacterial extracts.
(2018)With bacterial antimicrobial resistance on the rise, alternative therapeutic agents are being sought. One such alternative is the use of anti-virulence strategies such as quorum-sensing inhibition (QSI), which has been ... -
Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
(2018)Emerging drug resistance hinders the efforts to control malaria and so novel antimalarial drugs are required. Copper is essential for the survival of plasmodial parasites but the proteins involved in copper homeostasis are ... -
Anti-c-myc cholesterol-based lipoplexes: development, characterisation and evaluation as Onconanotherapeutic agents in vitro.
(2018)Strategies aimed at inhibiting the expression of the c-myc oncogene could provide the basis for alternative cancer treatment. In this regard, silencing c-myc expression using small interfering RNA (siRNA) is an attractive ... -
Screening for biosurfactant production amongst aerobic endospore forming bacteria isolated from Mfabeni peatland sediment core.
(2019)Abbstract available in pdf. -
Screening, purification and characterisation of anti-pseudomonas aeruginosa compounds produced by endophytic fungi from Kigelia Africana.
(2018)The emergence of new diseases and drug resistant pathogens coupled with the side effects presented by conventional or synthetic drug use calls for the discovery of new antibiotics and chemotherapeutics. Pseudomonas aeruginosa ...
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