Doctoral Degrees (Pharmaceutical Sciences)
Recent Submissions
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Combinatorial in-silico modeling and bioinformatics analysis of immune proteins and small-molecular weight inhibitors: a potential for cancer chemotherapy.
(2020)The immune system carries out pivotal functions in the protection of the body from damaging substances, microbes, and cellular alteration that could affect the health of an individual. The component of the immune system ... -
The in silico investigation of the perplexity of synergistic duality: inter-molecular mechanisms of communication in Bcr–Abl.
(2019)Due to their important role in normal cellular physiology, protein kinase activity is tightly regulated and their aberrant activation can lead to cancer. Chronic myeloid leukaemia (CML) is a blood cancer described by ... -
Evaluating the impact of the change in regulations related to medicine pricing and pharmacy ownership in the private pharmaceutical sector of South Africa.
(2020)One of the imperatives of the post-1994 government was to improve access to medicines and related pharmaceutical services to previously disadvantaged areas. The government implemented multiple strategies to achieve this ... -
Design, synthesis and spectral characterization of quinazoline and benzoxazine derivatives as novel DNA gyrase inhibitors.
(2020)Tuberculosis (TB) has remained one of the leading causes of the death worldwide and recently surpassed HIV/AIDS as lethal disease caused by a single infectious agent. Further, development of resistance against frontline ... -
Evaluation of the management of HIV/AIDs with diabetes as a comorbid condition in public health facilities in eThekwini Metro of KwaZulu-Natal: defining contributory factors to patient outcomes.
(2020)Introduction HIV/AIDS has remained a huge burden. It is still affecting large population of people globally with mortality of over 35 million people. South Africa is the most affected country. Substantial progress has ... -
Development of a framework for the standardization of management of diabetes and hypertension: the case of Tswanas and Zulus of South Africa.
(2019)Introduction: In sub-Saharan Africa, available World Health Organization data indicate an increase in the prevalence rate of non-communicable diseases such as diabetes and hypertension. Dwindling economies, rising costs ... -
Synthesis, characterization and application of novel composite nano-materials for the electrochemical detection of MRSA and related drugs.
(2020)This thesis reports the development of electroanalytical methods applicable for detection of MRSA and selected antibacterial drugs; vancomycin and ciprofloxacin. The detection techniques used to carryout all electrochemical ... -
Sub/supercritical fluid chromatography purification of biologics.
(2020)Peptide and protein drugs are highly versatile with numerous therapeutic properties such as anti-cancer, anti-diabetic, anti-hypertensive, and anti-microbial; which are therefore ideal candidates for the development of ... -
The mechanistic modelling of HIV-1 protease and its natural substrates: a theoretical perspective.
(2020)An epidemic that has had profound impact on humanity both culturally and health-wise in recent decades is the Acquired immunodeficiency syndrome (AIDS) triggered by the Human immunodeficiency virus (HIV). The developments ... -
Innovative self-assembling nanodelivery systems to combat bacterial infections.
(2020)The rising surge of bacterial resistance puts an immense economic and social strain on the healthcare system worldwide. Unfortunately, the production of new antibiotics is significantly outstripped by existing therapies ... -
Insight into cancer targets and ligand binding landscape using bioinformatics and integrated molecular modeling tools.
(2017)The alarming rate of varying types of cancer diseases in human remains a global burden requiring drastic treatment in which, a prominent method of combating it is through enzymebased drug design. Metastatic castration-resistant ... -
Novel series of dehydrozingerone inspired potential antimycobacterial agents: design, synthesis, spectral studies and in vitro biological evaluation.
(2016)Tuberculosis (TB) is a key health burden globally. With the emergence of resistance issue, the antitubercular research has been challenging. Novel effective drugs are immediately required to treat this serious epidemic ... -
Complexation strategies for the design of novel nano-drug delivery systems to treat bacterial infections caused by superbugs.
(2019)Abstract available in the PDF. -
Novel lipidic materials to enhance the transdermal delivery of tenofovir.
(2017)The global burden of HIV and AIDS coupled with the limitations of current oral tenofovir (TNF) administration drives the need to develop strategies such as the use of alternate routes of administration to improve drug ... -
Neuro-immunological investigation of auto-immune thyroid factors in bipolar disease.
(2017)Introduction: The co-incidence of thyroid auto-immunity and neuro-psychiatric disorders is well-documented. However, the prevailing school of thought implicating auto-immune thyroid disease (AITD) in bipolar disorder is ... -
Molecular profile of gram-negative ESKAPE pathogens from Komfo Anokye Teaching Hospital in Ghana.
(2017)Gram-negative ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp) pathogens are a major healthcare concern globally due to their ... -
Molecular analysis of HIV-1 resistance: biosynthesis, kinetic, and thermodynamic study of resistant HIV-PROTEASE (C-SA) mutants.
(2018)Abstract available in pdf. -
Investigating the inhibition mechanism of L,D- transpeptidase 5 from Mycobacterium tuberculosis computational methods.
(2018)Abstract available in pdf. -
Meeting South Africa's pharmacovigilance challenges in the face of rapidly increasing public health treatment programmes.
(2016)Among South Africa‘s (SA‘s) many public health challenges, having the largest treatment programmes globally is a significant challenge. The latter requires a robust pharmacovigilance (PV) programme. The purpose of this ...
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