Doctoral Degrees (Pharmaceutical Sciences)
Recent Submissions
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Design of advanced materials and nano delivery approaches for enhancing activity against Methicillin resistant Staphylococcus aureus.
(2018)Infectious diseases, including bacterial infections, continue to be a significant cause of morbidity and mortality globally, antimicrobial resistance has further made them fatal. Limitations of conventional dosage forms ... -
The methyltransferase and helicase enzymes as therapeutic targets of Zika virus : a bio- computational analysis of interactions with potential inhibitors.
(2019)The rampant Zika virus has received worldwide attention after becoming a global crisis following the Brazilian epidemic in 2015. From an obscure and neglected pathogen, Zika virus is now a notorious virus associated with ... -
In silico investigation of hepatitis c virus: a novel perspective into targeted viral inhibition of NS3 helicase, NS 3/4a protease and NS5b RNA dependent RNA polymerase.
(2019)Hepatitis C Virus (HCV) is an escalating global healthcare and economic burden that requires extensive intervention to alleviate its control. Over the years, drug design efforts have produced many anti-HCV drugs; however, ... -
The in silico investigation of pharmacological targets of the zika virus : insights into the structural characteristics of the NS5 and NS3 proteins from atomistic molecular simulations.
(2017)The re-emerging Zika virus has evolved into a catastrophic epidemic during the past year, with an estimated 1.5 million reported cases of Zika infections worldwide, since the 2015 outbreak in Brazil. The virus has received ... -
Investigating plasmepsin flexibility as a function of the flap region : a unique structural and dynamic feature of aspartic protease.
(2015)Malaria is one of the most deadly infectious protozoan diseases known to man. It is spread by the Plasmodium parasite through the bite of the female Anopheles mosquito. Increasing resistance to currently available antimalarial ... -
A computational perspective of influenza a virus targets : neuraminidase and endonuclease.
(2016)Through the ages the viruses have plagued mankind claiming the lives of millions, pre-dating any advancements in the medicinal sciences. One such pathogenic virus is influenza A, which has been implicated in the 1918-Spanish ... -
The antibiotic treatment of gram negative bacteremia-pharmacokinetics and dynamics.
Abstract available in PDF file. -
Some pharmacological properties of Harpagophytum procumbens DC [Pedaliaceae] secondary root extract
(2004)Abstract available on PDF file. -
Pharmacokinetics and pharmacodynamics of glibenclamide in type 2 diabetics.
Abstract available in PDF file. -
A study of the relationship between the pharmacokinetics and the pharmacodynamics of atenolol in black and white subjects using an effect modelling technique.
(1991)Abstract is available in PDF file. -
Exploring the buccal delivery potential of an antiretroviral drug.
Whilst antiretroviral drugs (ARVs) have significantly improved treatment of Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome (HIV and AIDS), several limitations exist with their oral route ... -
Diverse computational tools towards the understanding of HIV targets and design of potential drug candidates.
HIV/AIDS still remains to be a challenging epidemic infecting millions of individuals worldwide. The morbidity and mortality rates of HIV-infected patients has been well documented over the years. Despite on-going HIV/AIDS ... -
Grapefruit juice ameliorates nephropathy in streptozotocin induced diabetes.
(2012)Background Diabetic Nephropathy (DN) is the leading cause of end stage renal disease and mortality in diabetic patients. Over the years, medicinal plants have been used to manage diabetes and its complications. Metformin, ... -
Integrating human immunodeficiency virus and tuberculosis drug treatment.
(2014)The human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics are major global public health challenges. Worldwide, approximately 42% of TB patients are also co-infected with HIV, and sub-Saharan Africa (SSA) ... -
Bioavailability studies on various dosage forms of the anorectic, diethylpropion hydrochloride.
(1984)The stereo-chemistry, structure activity relationships and the metabolism of the anorectic drug, diethylpropion hydrochloride, have been reviewed briefly, together with the analytical methods for the determination of this ... -
An investigation of the antidiabetic herbal remedies used by traditional healers in Northern KwaZulu-Natal and their effect on blood glucose levels.
(1998)This research study undertook to investigate and evaluate for efficacy and safety, the herbal remedies used for treating Diabetes mellitus in northern KwaZulu-Natal. In addition, it sought to gain knowledge and better ... -
The pharmacokinetics/pharmacodynamics of theophylline in premature neonates during the first few days after birth.
(2000)Theophylline is one of the few preparations available for the treatment of apnoea of prematurity. Currently little data is available on the pharmacokinetics and the pharmacokinetic/pharmacodynamic relationships of ... -
Studies on some pharmacological properties of Capsicum frutescens-driven capsaicin in experimental animal models.
(2012)The present study investigated pharmacological properties of Capsicum frutescens-derived capsaicin, including its analgesic, anti-inflammatory and coagulatory properties. The effects of capsaicin on gastrointestinal and ...
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