Doctoral Degrees (Pharmaceutical Sciences)
Recent Submissions
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Insight into cancer targets and ligand binding landscape using bioinformatics and integrated molecular modeling tools.
(2017)The alarming rate of varying types of cancer diseases in human remains a global burden requiring drastic treatment in which, a prominent method of combating it is through enzymebased drug design. Metastatic castration-resistant ... -
Novel series of dehydrozingerone inspired potential antimycobacterial agents: design, synthesis, spectral studies and in vitro biological evaluation.
(2016)Tuberculosis (TB) is a key health burden globally. With the emergence of resistance issue, the antitubercular research has been challenging. Novel effective drugs are immediately required to treat this serious epidemic ... -
Complexation strategies for the design of novel nano-drug delivery systems to treat bacterial infections caused by superbugs.
(2019)Abstract available in the PDF. -
Novel lipidic materials to enhance the transdermal delivery of tenofovir.
(2017)The global burden of HIV and AIDS coupled with the limitations of current oral tenofovir (TNF) administration drives the need to develop strategies such as the use of alternate routes of administration to improve drug ... -
Neuro-immunological investigation of auto-immune thyroid factors in bipolar disease.
(2017)Introduction: The co-incidence of thyroid auto-immunity and neuro-psychiatric disorders is well-documented. However, the prevailing school of thought implicating auto-immune thyroid disease (AITD) in bipolar disorder is ... -
Molecular profile of gram-negative ESKAPE pathogens from Komfo Anokye Teaching Hospital in Ghana.
(2017)Gram-negative ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp) pathogens are a major healthcare concern globally due to their ... -
Molecular analysis of HIV-1 resistance: biosynthesis, kinetic, and thermodynamic study of resistant HIV-PROTEASE (C-SA) mutants.
(2018)Abstract available in pdf. -
Investigating the inhibition mechanism of L,D- transpeptidase 5 from Mycobacterium tuberculosis computational methods.
(2018)Abstract available in pdf. -
Meeting South Africa's pharmacovigilance challenges in the face of rapidly increasing public health treatment programmes.
(2016)Among South Africa‘s (SA‘s) many public health challenges, having the largest treatment programmes globally is a significant challenge. The latter requires a robust pharmacovigilance (PV) programme. The purpose of this ... -
Synthesis and evaluation of peptides for radiopharmaceutical applications.
(2017)Bacterial infection is considered as one of the major threats to human life as well as to the global economy; especially with the increasing number of new multidrug resistant strains. Timely as well as accurate diagnosis ... -
A Computational perspective on the concerted cleavage mechanism of the natural targets of HIV-1 protease.
(2018)One infectious disease that has had both a profound health and cultural impact on the human race in recent decades is the Acquired Immune Deficiency Syndrome (AIDS) caused by the Human Immunodeficiency Virus (HIV). A ... -
Molecular epidemiology of livestock-associated Methicillin resistant Staphylococcus aureus (LA-MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in pigs and exposed workers in Cameroon and South Africa.
(2017)Livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) and extendedspectrum β-Lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) are amongst the main resistant bacteria of serious public health ... -
Design, synthesis and pharmacological evaluation of novel fused pyrimidine analogues as anticancer agents.
(2018)Cancer is a multifaceted disease considered as the most serious health burden all over the world. Due to existing of limited anticancer drugs and detrimental side effects, the anticancer research has been challenging. ... -
An investigation into the use of complementary and alternative medicine for atopic eczema.
(2016)Atopic eczema (AE) is one of the most common skin diseases that patients frequently present with to dermatological practices in South Africa (SA). It has shown to impact negatively on the quality of life of many patients ... -
Mass spectrometric imaging for Tuberculosis drug development.
(2017)For many years, Tuberculosis (TB) has plagued the human race claiming millions, if not billions, of lives. With the advent of short-course chemotherapy TB has become a manageable disease, however in recent times Mycobacterium ... -
Design of advanced materials and nano delivery approaches for enhancing activity against Methicillin resistant Staphylococcus aureus.
(2018)Infectious diseases, including bacterial infections, continue to be a significant cause of morbidity and mortality globally, antimicrobial resistance has further made them fatal. Limitations of conventional dosage forms ... -
The methyltransferase and helicase enzymes as therapeutic targets of Zika virus : a bio- computational analysis of interactions with potential inhibitors.
(2019)The rampant Zika virus has received worldwide attention after becoming a global crisis following the Brazilian epidemic in 2015. From an obscure and neglected pathogen, Zika virus is now a notorious virus associated with ... -
In silico investigation of hepatitis c virus: a novel perspective into targeted viral inhibition of NS3 helicase, NS 3/4a protease and NS5b RNA dependent RNA polymerase.
(2019)Hepatitis C Virus (HCV) is an escalating global healthcare and economic burden that requires extensive intervention to alleviate its control. Over the years, drug design efforts have produced many anti-HCV drugs; however, ...
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