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dc.creatorWei, Xierong.
dc.creatorHunt, Gillian.
dc.creatorAbdool Karim, Salim Safurdeen.
dc.creatorNaranbhai, Vivek.
dc.creatorSibeko, Sengeziwe.
dc.creatorAbdool Karim, Quarraisha.
dc.creatorLi, Jin-fen.
dc.creatorKashuba, Angela D. M.
dc.creatorWerner, Lise.
dc.creatorPassmore, Jo-Ann Shelley.
dc.creatorMorris, Lynn.
dc.creatorHeneine, Walid.
dc.creatorJohnson, Jeffrey A.
dc.date.accessioned2016-10-27T06:52:50Z
dc.date.available2016-10-27T06:52:50Z
dc.date.created2014
dc.date.issued2014
dc.identifier.citationWei, X., Hunt, G., Karim, S.S.A., Naranbhai, V., Sibeko, S., Karim, Q.A., Li, J.F., Kashuba, A.D., Werner, L., Passmore, J.A.S. Morris, L., Heneine, W., and Johnson, J.A. 2014. Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial. Journal of Infectious Diseases 209(12), 1916-1920.en_US
dc.identifier.urihttp://dx.doi.org/10.1093/infdis/jiu026en_US
dc.identifier.urihttp://hdl.handle.net/10413/13546
dc.descriptionCAPRISA, 2014.en_US
dc.description.abstractThe Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction-based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.en_US
dc.language.isoenen_US
dc.publisherOxford University Press.en_US
dc.subjectVaginal microbicide.en_US
dc.subjectHIV prevention.en_US
dc.subjectPre-preexposure.en_US
dc.subjectTenofovir gel.en_US
dc.subjectTopical PrEP.en_US
dc.titleSensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.en_US
dc.typePeer reviewed journal articleen_US


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