Browsing by Author "O'Donnell, Max Roe."

Now showing 1 - 7 of 7

Adherence in the treatment of patients with extensively drug-resistant tuberculosis and HIV in South Africa: a prospective cohort study.
(Lippincott Williams & Wilkins., 2014) O'Donnell, Max Roe.; Wolf, Allison.; Werner, Lise.; Horsburgh, Charles Robert.; Padayatchi, Nesri.
Abstract available in pdf.
Antiretroviral switching and bedaquiline treatment of drug-resistant tuberculosis HIV co-infection.
(Elsevier., 2019) Padayatchi, Nesri.; Daftary, Amrita.; Orrell, Catherine.; Dooley, Kelly E.; O'Donnell, Max Roe.; Amico, Kathy Rivet.; Friedland, Gerald H.
Abstract available in PDF.
Clofazimine in the treatment of extensively drug-resistant tuberculosis with HIV coinfection in South Africa: a retrospective cohort study.
(Oxford University Press., 2014) Padayatchi, Nesri.; Gopal, Murali.; Naidoo, Rowena.; Werner, Lise.; Naidoo, Kimesh.; Master, Iqbal.; O'Donnell, Max Roe.
Abstract available in pdf.
Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal.
(Public Library of Science., 2015) Cohen, Keira A.; Abeel, Thomas.; McGuire, Abigail Manson.; Desjardins, Christopher A.; Munsamy, Vanisha.; Shea, Terrance P.; Walker, Bruce J.; Bantubani, Nonkqubela.; Almeida, Deepak V.; Alvarado, Lucia.; Chapman, Sinéad B.; Mvelase, Nomonde R.; Duffy, Eamon Y.; Fitzgerald, Michael G.; Govender, Pamla.; Gujja, Sharvari.; Hamilton, Susanna.; Howarth, Clinton.; Larimer, Jeffrey D.; Maharaj, Kashmeel.; Pearson, Matthew D.; Priest, Margaret E.; Zeng, Qiandong.; Padayatchi, Nesri.; Grosset, Jacques H.; Young, Sarah K.; Wortman, Jennifer.; Mlisana, Koleka Patience.; O'Donnell, Max Roe.; Birren, Bruce W.; Bishai, William R.; Pym, Alexander S.; Earl, Ashlee M.
Abstract available in pdf.
Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa.
(BioMed Central., 2018) Bionghi, Neda.; Daftary, Amrita.; Maharaj, Bhavna.; Msibi, Zama Princess N.; Rivet Amico, K.; Friedland, Gerald H.; Orrell, Catherine.; Padayatchi, Nesri.; O'Donnell, Max Roe.
Abstract available in pdf.
TB/HIV: an orphan disease?
(American Thoracic Society., 2011) Brust, James C. M.; O'Donnell, Max Roe.; Metcalfe, John Z.
No abstract available.
Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection.
(U.S. National Center for Infectious Diseases., 2013) O'Donnell, Max Roe.; Padayatchi, Nesri.; Kvasnovsky, Charlotte.; Werner, Lise.; Master, Iqbal.; Horsburgh, Charles Robert.
High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3–9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) defaulted from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.