Repository logo

Browsing by Author "Mofenson, Lynne Meryl."

Filter results by typing the first few letters
Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Benefits and risks of antiretroviral therapy for perinatal HIV prevention.
    (Massachusetts Medical Society., 2016) Fowler, Mary Glenn.; Qin, Min.; Fiscus, Susan A.; Currier, Judith S.; Flynn, Patricia M.; Chipato, Tsungai.; McIntyre, James.; Gnanashanmugam, Devasena.; Siberry, George K.; Coletti, Anne S.; Taha, Taha E.; Klingman, Karin L.; Martinson, Francis E.; Owor, Maxensia.; Violari, Avy.; Moodley, Dhayendre.; Theron, Gerhard.; Bhosale, Ramesh.; Bobat, Raziya Ahmed.; Chi, Benjamin H.; Strehlau, Renate.; Mlay, Pendo.; Loftis, Amy J.; Browning, Renee.; Fenton, Terence.; Purdue, Lynette.; Basar, Michael.; Shapiro, David E.; Mofenson, Lynne Meryl.
    Abstract available in pdf.
  • Thumbnail Image
    Item
    Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized, double-blind, placebo-controlled trial.
    (Lippincott Williams & Wilkins., 2013) Fowler, Mary Glenn.; Coovadia, Hoosen Mahomed.; Herron, Casey M.; Maldonado, Yvonne.; Chipato, Tsungai.; Moodley, Dhayendre.; Musoke, Philippa.; Aizire, Jim.; Manji, Karim.; Stranix-Chibanda, Lynda.; Fawzi, Wafaie.; Chetty, Vani.; Msweli, Lindiwe.; Kisenge, Rodrick Richard.; Brown, Elizabeth R.; Mwatha, Anthony.; Eshleman, Susan H.; Richardson, Paul.; Allen, Melissa.; George, Kathleen.; Andrew, Philip.; Zwerski, Sheryl.; Mofenson, Lynne Meryl.; Jackson, Jay Brooks.
    Abstract available in PDF file.
  • Thumbnail Image
    Item
    Impact of maternal and infant antiretroviral drug regimens on drug resistance in HIV-infected breastfeeding infants.
    (Pediatric Infectious Disease Journal, 2013) Fogel, Jessica M.; Mwatha, Anthony.; Brown, Elizabeth R.; Richardson, Paul.; Chipato, Tsungai.; Alexandre, Michel.; Moodley, Dhayendre.; Elbireer, Ali.; Mirochnick, Mark.; George, Kathleen.; Mofenson, Lynne Meryl.; Zwerski, Sheryl.; Eshleman, Susan H.; Coovadia, Hoosen Mahomed.
    Background: The HIV Prevention Trials Network (HPTN) 046 trial evaluated the efficacy of extended infant nevirapine (NVP) administration for prevention of HIV transmission through breastfeeding. Infants received daily NVP up to 6 weeks of age. HIV-uninfected infants (the intent-to-treat group) received daily NVP or placebo up to 6 months of age. We analyzed emergence of NVP resistance in infants who acquired HIV infection despite prophylaxis. Methods: HIV genotyping was performed using the ViroSeq HIV Genotyping System. Medians and proportions were used to summarize data. Two-sided Fisher exact tests were used to evaluate associations between categorical variables. Results: NVP resistance was detected in 12 (92.3%) of 13 infants who were HIV-infected by 6 weeks and in 7 (28%) of 25 infants who were HIVuninfected at 6 weeks and HIV-infected at 6 months of age (6/8 = 75% in the NVP arm, 1/17 = 5.9% in the placebo arm, P = 0.001). Among those 25 infants, 4 had mothers who initiated an antiretroviral treatment regimen by 6 months postpartum. In all 4 cases, the treatment regimen included a nonnucleoside reverse transcriptase inhibitor (NVP or efavirenz). NVP resistance was detected in all 4 of those infants by 6 months of age (4/4 = 100%). In contrast, only 3 (14.2%) of the remaining 21 HIV-infected infants whose mothers did not initiate antiretroviral treatment developed NVP resistance (P = 0.003). Conclusions: Extended NVP prophylaxis significantly increased the risk of NVP resistance in infants who acquired HIV infection after 6 weeks of age. Treatment of maternal HIV infection was also associated with emergence of NVP resistance in HIV-infected, breastfed infants.
  • Thumbnail Image
    Item
    Prevention of HIV-1 transmission through breastfeeding: efficacy and safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE): a randomized, open label, clinical trial.
    (Wolters Kluwer., 2018) Flynn, Patricia M.; Taha, Taha E.; Cababasay, Mae.; Fowler, Mary Glenn.; Mofenson, Lynne Meryl.; Owor, Maxensia.; Fiscus, Susan A.; Stranix-Chibanda, Lynda.; Coutsoudis, Anna.; Gnanashanmugam, Devasena.; Chakhtoura, Nahida.; McCarthy, Katie.; Mukuzunga, Cornelius.; Makanani, Bonus.; Moodley, Dhayendre.; Nematadzira, Teacler.; Kusakara, Bangini.; Patil, Sandesh.; Vhembo, Tichaona.; Bobat, Raziya Ahmed.; Mmbaga, Blandina T.; Masenya, Maysseb.; Nyati, Mandisa M.; Theron, Gerhard.; Mulenga, Helen.; Butler, Kevin.; Shapiro, David E.
    Abstract available in pdf.