Browsing by Author "McKinnon, Lyle R."
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Item Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells.(Lippincott Williams & Wilkins., 2015) McKinnon, Lyle R.; Nyanga, Billy.; Kim, Connie J.; Izulla, Preston.; Kwatampora, Jessie.; Kimani, Makobu.; Shahabi, Kamnoosh.; Mugo, Nelly.; Smith, Jennifer S.; Anzala, Omu.; Kimani, Joshua.; Kaul, Rupert.Abstract available in pdf.Item Ex vivo HIV entry into blood CD4+ T cells does not predict heterosexual HIV acquisition in women.(Public Library of Science., 2018) Joag, Vineet.; Sivro, Aida.; Yende-Zuma, Fortunate Nonhlanhla.; Imam, Hajra.; Samsunder, Natasha.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; McKinnon, Lyle R.; Kaul, Rupert.Abstract available in pdf.Item Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.(Nature Publishing Group., 2018) McKinnon, Lyle R.; Liebenberg, Lenine Julie.; Yende-Zuma, Fortunate Nonhlanhla.; Archary, Derseree.; Ngcapu, Sinaye.; Sivro, Aida.; Nagelkerke, Nico.; Garcia Lerma, Gerardo.; Kashuba, Angela D. M.; Masson, Lindi.; Mansoor, Leila Essop.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.Abstract available in pdf.Item Genital—systemic chemokine gradients and the risk of HIV acquisition in women.(Wolters Kluwer Health., 2017) Liebenberg, Lenine Julie.; Masson, Lindi.; Arnold, Kelly B.; McKinnon, Lyle R.; Werner, Lise.; Proctor, Elizabeth.; Archary, Derseree.; Mansoor, Leila Essop.; Lauffenburger, Douglas A.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.Abstract available in pdf.Item Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.(Nature., 2016) Arnold, Kelly B.; Burgener, Adam D.; Birse, Kenzie D. M.; Romas, Laura.; Dunphy, Laura J.; Shahabi, Kamnoosh.; Abou, Max.; Westmacott, Garrett R.; McCorrister, Stuart J.; Kwatampora, Jessie.; Nyanga, Billy.; Kimani, Joshua.; Masson, Lindi.; Liebenberg, Lenine Julie.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.; Lauffenburger, Douglas A.; Kaul, Rupert.; McKinnon, Lyle R.Abstract available in pdf.Item Interleukin 1-Beta (IL-1β) production by innate cells following TLR stimulation correlates with TB recurrence in art-treated HIV-infected patients.(Wolters Kluwer Health., 2017) Thobakgale, Christina Fanesa.; Naidoo, Kewreshini Kasturi.; McKinnon, Lyle R.; Werner, Lise.; Samsunder, Natasha.; Abdool Karim, Salim Safurdeen.; Ndung'u, Peter Thumbi.; Altfeld, Marcus.; Naidoo, Kogieleum.Abstract available.Item Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive.(Elsevier., 2015) Ngcapu, Sinaye.; Masson, Lindi.; Sibeko, Sengeziwe.; Werner, Lise.; McKinnon, Lyle R.; Mlisana, Koleka Patience.; Shey, Muki Shehu.; Samsunder, Natasha.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Passmore, Jo-Ann Shelley.Abstract available in pdf.Item Microbial translocation and microbiome dsybiosis in HIV-associated immune activation.(Wolters Kluwer., 2016) Zevin, Alexander S.; McKinnon, Lyle R.; Klatt, Nichole R.; Burgener, Adam D.Abstract available in pdf.Item Mucosal HIV shedding during ART.(Oxford University Press., 2017) Sivro, Aida.; McKinnon, Lyle R.Abstract available in pdf.Item Mx2 expression is associated with reduced susceptibility to HIV infection in highly exposed HIV seronegative Kenyan sex workers.(Wolters Kluwer., 2015) Stein, Derek R.; Shaw, Souradet Y.; McKinnon, Lyle R.; Abou, Max.; McCorrister, Stuart J.; Westmacott, Garrett R.; Fowke, Keith R.; Plummer, Francis A.; Ball, Terry Blake.Abstract available in pdf.Item Non-cationic proteins are associated with HIV neutralizing activity in genital secretions of female sex workers.(Public Library of Science., 2015) Birse, Kenzie D. M.; Cole, Amy L.; Hirbod, Taha.; McKinnon, Lyle R.; Ball, Terry Blake.; Westmacott, Garrett R.; Kimani, Joshua.; Plummer, Frank.; Cole, Alexander M.; Burgener, Adam D.; Broliden, Kristina.Abstract available in pdf.Item Rapid disease progression in HIV-1 subtype C–infected South African women.(Oxford University Press., 2014) Mlisana, Koleka Patience.; Werner, Lise.; Garrett, Nigel Joel.; McKinnon, Lyle R.; van Loggerenberg, Francois.; Passmore, Jo-Ann Shelley.; Gray, Clive M.; Morris, Lynn.; Williamson, Carolyn.; Abdool Karim, Salim Safurdeen.Background. Whereas human immunodeficiency virus (HIV) subtype B–infected individuals generally progress to AIDS within 8–10 years, limited data exist for other clades, especially from Africa. We investigated rates of HIV disease progression of clade C–infected South African women. Methods. Prospective seroincidence cohorts in KwaZulu-Natal were assessed for acute HIV infection monthly (n = 245) or every 3 months (n = 594) for up to 4 years. Rapid disease progression was defined as CD4 decline to <350 cells/μL by 2 years postinfection. Serial clinical and laboratory assessments were compared using survival analysis and logistic regression models. Results. Sixty-two women were identified at a median of 42 days postinfection (interquartile range, 34–59), contributing 282 person-years of follow-up. Mean CD4 count dropped by 39.6% at 3 months and 46.7% at 6 months postinfection in women with preinfection measurements. CD4 decline to <350 cells/μL occurred in 31%, 44%, and 55% of women at 1, 2, and 3 years postinfection, respectively, and to <500 cells/μL in 69%, 79%, and 81% at equivalent timepoints. Predictors of rapid progression were CD4 count at 3 months postinfection (hazard ratio [HR], 2.07; 95% confidence interval [CI], 1.31–3.28; P = .002), setpoint viral load (HR, 3.82; 95% CI, 1.51–9.67; P = .005), and hepatitis B coinfection (HR, 4.54; 95% CI, 1.31–15.69; P = .017). Conversely, presence of any of HLAB*1302, B*27, B*57, B*5801, or B*8101 alleles predicted non–rapid progression (HR, 0.19; 95% CI, .05–.74; P = .016). Conclusions. Nearly half of subtype C–infected women progressed to a CD4 count <350 cells/μL within 2 years of infection. Implementing 2013World Health Organization treatment guidelines (CD4 count <500 cells/μL) would require most individuals to start antiretroviral therapy within 1 year of HIV infection.Item The role of dendritic cells in driving genital tract inflammation and HIV transmission risk: are there opportunities to intervene?(Sage Publications., 2015) Shey, Muki Shehu.; Garrett, Nigel Joel.; McKinnon, Lyle R.; Passmore, Jo-Ann Shelley.Abstract available in pdf.Item Strengthening HIV surveillance in the antiretroviral therapy era: rationale and design of a longitudinal study to monitor HIV prevalence and incidence in the uMgungundlovu District, KwaZulu-Natal, South Africa.(BioMed Central., 2015) Kharsany, Ayesha Bibi Mahomed.; Cawood, Cherie.; Khanyile, David.; Grobler, Anna Christina.; McKinnon, Lyle R.; Samsunder, Natasha.; Fröhlich, Janet Ann.; Abdool Karim, Quarraisha.; Puren, Adrian.; Welte, Alex.; George, Gavin Lloyd.; Govender, Kaymarlin.; Toledo, Carlos.; Chipeta, Zawadi.; Zembe, Lycias.; Glenshaw, Mary T.; Madurai, Lorna.; Deyde, Varough M.; Bere, Alfred.Abstract available in pdf.Item Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.(American Association for the Advancement of Science., 2017) Klatt, Nichole R.; Cheu, Ryan.; Birse, Kenzie D. M.; Zevin, Alexander S.; Perner, Michelle.; Noël-Romas, Laura.; Grobler, Anna Christina.; Westmacott, Garrett R.; Xie, Irene Y.; Butler, Jennifer.; Mansoor, Leila Essop.; McKinnon, Lyle R.; Passmore, Jo-Ann Shelley.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Burgener, Adam D.Abstract available in pdf.