Browsing by Author "Bibollet-Ruche, F."

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Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection.
(American society for Microbiology., 2007-03-22) Moore, Penelope L.; Decker, Julie M.; Bibollet-Ruche, F.; Li, Hui.; Leseka, N.; Gray, Elin Solomonovna.; Choge, Isaac Ang'Ang'A.; Abdool Karim, Salim Safurdeen.; Treurnicht, Florette K.; Mlisana, Koleka Patience.; Shaw, George M.; Williamson, Carolyn.; Morris, Lynn.
The study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection.