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Browsing by Author "Alter, Galit."

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    Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.
    (Elsevier., 2012) Archary, Derseree.; Rong, Rong.; Gordon, Michelle Lucille.; Boliar, Saikat.; Madiga, Maphuti C.; Gray, Elin Solomonovna.; Dugast, Anne-Sophie.; Hermanus, Tandile.; Goulder, Philip Jeremy Renshaw.; Coovadia, Hoosen Mahomed.; Werner, Lise.; Morris, Lynn.; Alter, Galit.; Derdeyn, Cynthia A.; Ndung'u, Peter Thumbi.
    Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher than contemporaneous responses at study entry (p=0.002) and exit (p=0.01). NAb breadth and potencies against subtype C viruses were significantly higher than for subtype A (p=0.03 and p=0.01) or B viruses (p=0.03; p=0.05) respectively. Gp41-IgG binding affinity was higher than gp120-IgG (p=0.0002). IgG–FcγR1 affinity was significantly higher than FcγRIIIa (p<0.005) at study entry and FcγRIIb (p<0.05) or FcγRIIIa (p<0.005) at study exit. Evolving IgG binding suggests alteration of immune function mediated by binding antibodies. Evolution of nAbs was a potential marker of HIV-1 disease progression.
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    HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.
    (Public Library of Science., 2018) Richardson, Simone I.; Chung, Amy W.; Natarajan, Harini.; Mabvakure, Batsirai.; Mkhize, Nonhlanhla N.; Garrett, Nigel Joel.; Abdool Karim, Salim Safurdeen.; Moore, Penelope L.; Ackerman, Margaret E.; Alter, Galit.; Morris, Lynn.
    Abstract available in pdf.