Masters Degrees (Physiology)
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Browsing Masters Degrees (Physiology) by Author "Burger, F. J."
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Item The effect of dietary egg on human plasma cholesterol and triglyceride levels.(1990) Raidoo, Kogie.; Burger, F. J.No abstract available.Item The effect of vitamin B-6 deficiency on copper, zinc and iron balance in the rat.(1988) Channa, Mahendra Lala.; Burger, F. J.In order to address the contradictory reports on the rat trace element status during a vitamin 8-6 deficiency, Zn, Cu and Fe balance was assessed over 8 weeks in 3 groups of young male rats. Group 1 was the control group fed on a diet supplemented with 3,5 mg/kg of vitamin B-6. Group 2 was the marginally deficient group, fed a diet supplemented with 1,75 mg/kg of vitamin B-6 and Group 3 was the totally deficient group without any vitamin 8-6 in the diet. Diet, urine and fecal samples were analysed to determine the mean daily Zn, Cu and Fe balance for each group during each week of the study. Urinary xanthurenic acid (XA), plasma pyridoxal (PL), and plasma pyridoxal 5' -phosphate (PLP) were also analysed in order to determine the vitamin 8-6 nutritional status of each animal group. The totally deficient Group 3 showed decreased growth and food consumption when compared to the control and marginally deficient groups. There was a significant difference in XA excretion and plasma PLP and PL levels between all 3 groups with a progressive increase in XA excretion and a progressive decrease in PLP and PL levels from Group to Group 3. Although all groups were found to be in a positive balance for Zn, Cu and Fe, the totally deficient group was in a less positive balance compared to Groups 1 and 2. Furthermore, the percentage excretion of Zn and Cu, when compared to the intake, was greater in this group. This increased excretion, coupled with a decreased food intake, accounted for the lowered Zn and Cu balances in the totally deficient group. Fe excretion did not differ significantly between all 3 groups. The marginally deficient Group 2 showed no significant difference in growth, food consumption, trace element balance and excretion when compared to the control group, indicating the beneficial effects of even subminimal levels of vitamin B-6. This study confirms that the nutritional status of t~ace elements, especially that of Zn and CU, is related to the vitamin B-6 status of the animal.Item The effect of vitamin B-6 deficiency on the bioavailability of zinc in the rat.(1990) Moodley, Dhanabaikum.; Burger, F. J.No abstract available.Item The effect of vitamin B-6 deficiency on the levels of tissue copper, iron and zinc in the rat.(1989) Mackraj, Irene.; Burger, F. J.No abstract available.Item The interrelationship of dietary cholesterol, copper and zinc on plasma lipids and tissue copper and zinc levels in the rat.(1992) Nadar, Anand.; Burger, F. J.No abstract available.Item The interrelationship of dietary cholesterol, copper and zinc on plasma lipids and tissue copper and zinc levels in the rat.(1992) Anand, Nadar.; Burger, F. J.No abstract available.Item A quantification of heat load as assessed by indicators of tissue damage in rats.(1984) Manjoo, Mahomed.; Burger, F. J.; Kielblock, Artz Johan.Heatstroke is an illness that occurs when body temperature is grossly elevated, causing widespread tissue damage. The extent of tissue damage depends on the level of body temperature elevation and the duration. Despite the fact that the diagnosis of heatstroke is based on sound scientific principles, namely the elevation of serum enzyme levels as indicators of tissue damage, the sensitivity of these parameters of tissue damage in the prodromal period of heatstroke is less well established, especially for sub-lethal stress conditions. Furthermore, it is not known to what extent given elevations in serum enzyme levels reflect the nature of various combinations of hyperthermia and its duration as sustained during the prodromal period. In an attempt to throw some light on the questions posed above anaesthetized rats were exposed to three different sets of thermal conditions. However, the amount of heat gained over and above baseline levels was controlled to a 20% rise irrespective of the experimental conditions. Above this increment animals did not survive thus indicating excessive stress. Plasma enzyme levels were assayed in each group of animals upon termination of stress, six hours post-stress and 24 hours post-stress in order to investigate the patterns of enzyme release as well as the sensitivity of the respective indicators of tissue damage. On the basis of plasma enzyme assays, the tissue damage sustained during these particular experimental conditions was mild to moderate, completely reversible, not indicative of heatstroke but merely of generalized tissue damage. The results suggest that in addition to the established positive relationship between the level and duration of hyperthermia and tissue damage, a third component,namely the rate of rise in body temperature, nay constitute an important factor in the ultirrate pathology. In this regard, i.e. sub-lethal stress, creatine kinase proved to be the most sensitive and, therefore, the most useful parameter of tissue damage.