Browsing Medical Microbiology by Type "Thesis"
Now showing items 1-20 of 65
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Aflatoxin B1 modulates oxidative stress and apoptosis in human embryonic kidney cells.
(2019)Introduction: Aflatoxin B1 (AFB1) is produced by filamentous fungal strains of Aspergillus flavus and Aspergillus parasiticus that infect field crops, therefore AFB1 is a frequent contaminant of dietary staples such as ... -
Antibiotic resistance in mycobacterium tuberculosis : the role of genetic mutations in resistance conferring genes and efflux transporters.
(2016)Two decades after the World Health Organisation (WHO) declaration of tuberculosis (TB) as a global emergency, the disease remains a public health crisis of epic proportions. The emergence of drug resistant strains of ... -
Antimicrobial properties of traditional medicine used for treatment of HIV/AIDS and its opportunistic infections.
(2012)This study was conducted to establish the scientific basis of the reported ethnomedicinal use of Ihlamvu laseAfrika (IHL) against Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Virus (AIDS) related ... -
Cytokine production by ME-180 cells and VK2 E6/E7 cells on exposure to Neisseria gonorrhoeae, HIV, N. gonorrhoeae and HIV.
(2018)Gonorrhoea is a sexually transmitted disease caused by Neisseria gonorrhoeae. Women are more at risk in developing secondary complications due to asymptomatic infections. In 2001, a study was done on the different responses ... -
The cytotoxic effects of fumonisin B1 in human kidney cells and the ability of allicin to ameliorate these effects.
(2019)Fumonisin B1 (FB1) is a widespread contaminant of crops and is produced as a secondary metabolite of fungi. It has been found to disrupt sphingolipid metabolism, cause epigenetic modifications and induce cellular toxicity ... -
A descriptive analysis of the routine use of genotype MTBDRsl in a high HIV/TB prevalent region in South Africa.
(2020)Background. Since the implementation of shortened drug regimens for the management of drug resistant tuberculosis (TB), there is a growing need for rapid detection of resistance to second line antimycobacterial drugs. The ... -
The development and application of a high throughput methodology to determine MICs of Mycobacterium tuberculosis isolates against antimicrobial agents.
(2014)Chapter 1 of this dissertation entails the introduction, aims, objectives and the literature review. Drug susceptibility testing of Mycobacterium tuberculosis is time consuming and expensive. Multi-point inoculation offers ... -
The development of a stratified keratinocyte model for chlamydia trachomatis pathogenesis studies.
(2017)A number of different methods to generate stratified keratinocyte layers have been published. These involved the use of normal human epidermal keratinocytes (NHEKs/NEKS), which have a better ability to stratify compared ... -
Development of an antigen detection based point-of-care test for the diagnosis of primary syphilis.
(2011)Aim: To develop an antigen detection based, point-of-care test that will rapidly exclude syphilitic infection in patients presenting with genital ulcers. Materials and Method: T. pallidum subsp pallidum, Nichols strain, ... -
Development of novel reagents for tuberculosis detection.
(2013)Tuberculosis (TB) is one of the most prevalent infectious diseases worldwide and causes high morbidity and mortality, despite the widespread availability of effective antibiotics against most strains of Mycobacterium ... -
Differences in the susceptibility of mycobacterium tuberculosis to the 1st and 2nd line antituberculosis drugs under aerobic and anaerobic conditions.
(2015)Although Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is now considered a facultative anaerobe, and bacilli isolated from sputum specimen possess morphologies identified from bacilli growing ... -
Drug susceptibility testing of second and third line anti-tuberculosis drugs used in the management of extensively drug resistant tuberculosis.
(2013)Drug resistant tuberculosis is a major contributor to South Africa’s quadruple burden of disease. Management of this infection in a highly HIV endemic area is a constant challenge. There is a paucity of new anti-tuberculosis ... -
The effect of antimicrobials used for genital discharge disease on trichomonas vaginalis.
(2017)Trichomoniasis is the most common sexually transmitted infection caused by the protozoan, Trichomonas vaginalis. T. vaginalis infection is often asymptomatic. This infection causes vaginal discharge in women and urethritis ... -
The effect of genital tract inflammation on HIV-specific binding antibodies, IgG subclass and Isotype transudation.
(2019)Abstract available in PDF file. -
The effect of HIV and Neisseria gonorrhoeae on the tight junctions of cervical epithelial cells.
(2020)Introduction: Neisseria gonorrhoeae and HIV are major public health concerns globally. The interaction between these diseases is unclear. To determine the effect that N. gonorrhoeae and HIV have on the tight junctions of ... -
Effect of the capsular material of cryptococcus neoformans on the interplay between Mmicroglial cells and Neutrophils.
(2019)Cryptococcal meningitis is an important opportunistic infection in immunocompromised patients. It has been well established that a distinguishing feature of this form of meningitis is a relatively low neutrophil count in ... -
Effectiveness of a monovalent human rotavirus vaccine among children of 5 years and under in KwaZulu-Natal.
(2016)Human rotavirus infection is the leading cause of gastroenteritis in infants and young children worldwide. In South Africa, gastroenteritis is a major cause of childhood morbidity and mortality in children less than 5 ... -
Evaluation of the MTT and MABA assays for rapid screening of the in vitro activity of synthetic chalcones against Mycobacterium tuberculosis.
(2014)Background: The chalcone scaffold (1,3-diaryl-2-propen-i-ones) has the advantage of easy chemical modification and has been shown to possess biological activity against a variety of organisms, including a wide range of ... -
Fitness of multi-and extensively drug-resistant mycobacterium tuberculosis clinical strains.
(2015)The biological fitness of a pathogen is defined as its ability to reproduce, survive, cause disease and be transmitted. Drug-resistant M. tuberculosis isolates often exhibit reduced competitive ability against susceptible ...