Browsing Doctoral Degrees (Biochemistry) by Issue Date
Now showing items 21-40 of 76
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Endolysosomal proteolysis and its regulation.
(2003)The endolysosomal system is a multifunctional system and is involved in catabolism, antigen presentation and regulation of hormones. The descriptions of, and functions assigned to organelles within the system are often ... -
Changes in endosome-lysosome pH accompanying pre-malignant transformation.
(2005)The mechanisms by which altered processing, distribution and secretion of proteolytic enzymes occur, facilitating degradation of the extracellular matrix in invasive and metastatic cells, are not fully understood. Studies ... -
Using student difficulties to identify and model factors influencing the ability to interpret external representations of IgG-antigen binding.
(2005)Scientific external representations (ERs), such as diagrams, images, pictures, graphs and animations are considered to be powerful teaching and learning tools, because they assist learners in constructing mental models ... -
Targeted gene transfer to mammalian systems using liposome constructs containing cholesterol components with or without biotinylated molecular accessories.
(2005)Abstract available in PDF file. -
The presentation and interpretation of arrow symbolism in biology diagrams at secondary-level.
(2006)The literature contains conflicting ideas about the effectiveness of diagrams, and their constituent symbolism as teaching and learning tools. In addition, only limited research has been specifically conducted on the ... -
Biochemistry students' difficulties with the symbolic and visual language used in molecular biology.
(2007)This study reports on recurring difficulties experienced by undergraduate students with respect to understanding and interpretation of certain symbolism, nomenclature, terminology, shorthand notation, models and other ... -
Plasmodium yoelii acetyl-coa carboxylase : detection and characterisation of the recombinant biotinoyl domain.
(2008)Human malaria, caused by four species of the intracellular protozoan parasite Plasmodium, is a major health and economic burden in the tropics where the disease is endemic. The biotindependent enzyme acetyl-CoA carboxylase ... -
Effect of c-Ha-ras(V12) on protease trafficking in invasive breast cancer cells.
(2009)Effect of c-Ha-ras(V12) on cathepsin trafficking in invasive breast cancer cells. Various mutations of Ha-ras together with lack of p53-related control over cell cycle progression, result in an immortal, tumorigenic ... -
Effect of antimalarial drugs and malaria pigment ( *-haematin) on monocyte phagocytosis and GTP-cyclohydrolase 1 gene expression.
(2009)During the erythrocytic stage, the malaria parasite digests host cell haemoglobin into amino acids. Toxic haeme is released and is incorporated into an insoluble non-toxic crystal called haemozoin. Haemozoin is released ... -
Identification and characterisation of novel pathogenic factors of Trypanosoma congolense.
(2010)Trypanosoma congolense is a major causative agent of the bovine disease trypanosomosis which has a considerable economic impact on sub-Saharan Africa. Current control methods for trypanosomosis are unsatisfactory and ... -
Characterisation of infectious bursal disease virus (IBDV) polyprotein processing.
(2011)Infectious bursal disease virus (IBDV) is a birnavirus that infects the B-cells in the bursa of Fabricius of young chickens, causing Gumboro disease. The IBDV 114 kDa polyprotein (NH2-pVP2-VP4-VP3-COOH) is thought to be ... -
Gene disruption of TcoCATL (Congopain) and oligopeptidase B, pathogenic factors of African trypanosomes.
(2011)African trypanosomosis is a parasitic disease in man and animals caused by protozoan parasites of the genus Trypanosoma. T. congolense, T. vivax and T. brucei brucei cause nagana in cattle. The variable nature of the ... -
Quantitative imaging of tyrosine kinase-drug interactions in cells.
(2012)Kinases play a crucial role in regulating cellular signaling cascades, making them therapeutic targets for several human diseases. In human cancers, mis-regulation and mutations of kinases such as EGFR (epidermal growth ... -
The extracellular matrix regulates myoblast migration during wound healing.
(2012)Mammalian skeletal muscle can regenerate after injury and this response is primarily mediated by the satellite cell, a muscle stem cell. Following injury, satellite cells are activated to myoblasts, undergo rapid ... -
Some aspects of development and cell wall properties of the desiccation-sensitive embryos of Encephalartos natalensis (Zamiaceae)
(2013)The present investigation can be divided into two main sections: the first dealing with the post-shedding embryogenesis of Encephalartos natalensis and the second concerned with the cell wall properties of immature and ... -
Ecophysiological studies of the invasive weed Chromolaena odorata (L.) King and Robinson and its control in KwaZulu-Natal.
(2013)Despite increased interest in the control and spread of the alien weed, Chromolaena odorata, little is known of its photosynthetic characteristics under field conditions. The aim of the study was to obtain a better ... -
A biochemical and immunological comparison of the Jaagsiekte and two related retroviruses.
(1987)Jaagsiekte is a contagious cancer affecting the lungs of sheep. Although the etiological agent is Jaagsiekte retrovirus (JSRV), two other retroviruses viz South African maedi visna virus ( SA - OMVV) and a novel Bovine ... -
Effect of nitrate upon the digestibility of kikuyu grass (Pennisetum clandestinum)
(1985)The factors affecting the accumulation of nitrate in kikuyu grass pastures and the effect of elevated nitrate levels upon digestion in the ruminant were investigated. A high potassium level in the soil seems to be the ... -
Proteinases and extracellular matrix degradation in breast cancer.
(1996)A variety of proteases have been shown to promote the progression of cancer by virtue of their ability to degrade extracellular proteinaceous barriers, such as basement membrane and interstitial stroma. At the outset of ... -
Antibody-mediated inhibition of proteases of African trypanosomes.
(2006)The protozoan parasites Trypanosoma congolense and T. vivax cause trypanosomosis in cattle. The major lysosomal cysteine proteinase of T. congolense, congopain, may contribute to pathogenesis of the disease, and ...