Browsing Caprisa (Centre for the Aids programme of research in South Africa) by Title
Now showing items 219-238 of 447
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HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.
(Elsevier., 2006)The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries and regions of the world, and is undoubtedly the defining public-health crisis of our time. Research has deepened our understanding ... -
Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis.
(Public Library of Science., 2015)Abstract available in pdf. -
How ethical is your clinical trial?
(John Wiley & Sons., 2010)Is Institutional Review Board (IRB) approval and a rigorous informed consent process enough? It is our view that this is no longer the case. Conventional research ethics emphasise the importance of weighing the risks and ... -
Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point.
(American Society for Microbiology., 2008)It is unknown whether patterns of human immunodeficiency virus (HIV)-specific T-cell responses during acute infection may influence the viral set point and the course of disease. We wished to establish whether the magnitude ... -
Humanitarian access to unapproved interventions in public health emergencies of international concern.
(Public Library of Science., 2015)Abstract available in pdf. -
Identification and validation of a multi-assay algorithm for cross-sectional HIV incidence estimation in populations with subtype C infection.
(International AIDS Society., 2018)Abstract available in pdf. -
Identification of broadly neutralizing antibody epitopes in 1 the HIV-1 envelope glycoprotein using evolutionary models.
(Virology Journal, 2013)Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a computational ... -
Immune evaluation of HIV-infected and noninfected pre-eclamptics.
(MedPharm, 2009)No abstract available. -
The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.
(American College of Physicians., 2012)Background: Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients. Objective: To ... -
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.
(Cell Press., 2014)Abstract available in pdf. -
Impact of an adherence intervention on the effectiveness of tenofovir gel in the CAPRISA 004 trial.
(Springer., 2014)Abstract not available in pdf. -
Impact of antiretroviral therapy on health-related quality of life among South African women in the CAPRISA 002 acute infection study.
(Springer., 2014)Abstract available in pdf. -
Impact of blood processing variations on natural killer cell frequency, activation, chemokine receptor expression and function.
(Elsevier for Association of Medical Laboratory Immunologists., 2010)Understanding the role of natural killer (NK) cells in human disease pathogenesis is crucial and necessitates study of patient samples directly ex vivo. Manipulation of whole blood by density gradient centrifugation or ... -
The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa.
(Lippincott Williams & Wilkins., 2004)This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide ... -
Impact of maternal and infant antiretroviral drug regimens on drug resistance in HIV-infected breastfeeding infants.
(Pediatric Infectious Disease Journal, 2013)Background: The HIV Prevention Trials Network (HPTN) 046 trial evaluated the efficacy of extended infant nevirapine (NVP) administration for prevention of HIV transmission through breastfeeding. Infants received daily ... -
The impact of missing data on clinical trials : a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
(Springer., 2014)Rationale and objective Hypericum perforatum (St John's wort) is used to treat depression, but the effectiveness has not been established. Recent guidelines described the analysis of clinical trials with missing data, ... -
Implementation of adolescent-friendly voluntary medical male circumcision using a school based recruitment program in rural KwaZulu-Natal, South Africa.
(Public Library of Science., 2014)Background: Epidemiological data from South Africa demonstrate that risk of human immunodeficiency virus (HIV) infection in males increases dramatically after adolescence. Targeting adolescent HIV-negative males may be an ... -
Implementing isoniazid preventive therapy in a tuberculosis treatment-experienced cohort on ART.
(International Union against Tuberculosis and Lung Disease., 2017)Abstract available in pdf. -
Implementing microbicides in low-income countries.
(Elsevier., 2012)The magnitude of the global human immunodeficiency virus (HIV) epidemic is determined by women from lower income countries, specifically sub-Saharan Africa. Microbicides offer women who are unable to negotiate safe sex ...