Masters Degrees (Physiology)
Recent Submissions
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Evaluating the role of maternal separation stress on the development of autistic-like behaviour in Sprague-Dawley rats.
(2020)Autism Spectrum Disorders (ASD) are a category of neurodevelopmental disorders that have become more prevalent, causing much concern. Autistic individuals display symptoms ranging from repetitive behaviours to communication ... -
Effects of antipsychotic dose reduction on metabolic syndrome in patients with first episode psychosis treated with a long-acting injectable antipsychotic.
(2019)Background: The introduction of antipsychotics has been a significant milestone in the treatment of schizophrenia. However, these agents have several important side effects, such as metabolic syndrome. Options to curb these ... -
Effects of momordica balsamina on glucose handling in high fat high carbohydrate induced prediabetic rat model and glucose handling in C2C12 induced insulin resistant cell lines: effects on selected metabolic markers.
(2020)Increased consumption of fat and high carbohydrate coincided with increased prevalence in type 2 diabetes, a condition whose onset is always preceded by prediabetes. Prediabetes is best characterised by hyperglycaemia, ... -
The effects of prenatal stress on the preoptic nuclei of febrile seizure rat models.
(2019)Febrile seizures are a neurological abnormality that occurs after an underlying systemic infection, leading to fever and followed by convulsions due to neuronal hyper-excitability. Although regarded as benign, prenatal ... -
Effects of Momordica balsamina methanolic extract on cardiovascular and haematological function in streptozotocin-induced diabetic rats : effects on selected markers.
(2018)Background The hyperglycaemia-induced haemanetic changes reduces the oxygen-carrying capacity of erythrocytes, thus aggravating cardiovascular disorders in diabetic patients. The conventional therapies have been shown to ... -
Investigating changes to the insulin signalling pathway in a diet-induced pre-diabetic rat model: effects on selected markers.
(2019)No abstract available. -
A voice-centered relational analysis of the career development narratives of six Black African professionals in KwaZulu-Natal, South Africa.
(2018)Career Psychology and career education is not a new concept in the South African context, it is evident dating back as far as 1943. Literature shows that career guidance was first introduced in White schools and later ... -
HIV-1 transactivator of transcription (TAT) protein causes neurotoxicity via astrocyte activation.
(2015)HIV is most well-known for its negative effects on the immune system and the resulting development of AIDS, however it also has severe damaging effects on the central nervous system. Many infected individuals exhibit ... -
Prenatal stress and febrile seizures effects on the epigenetic mechanisms involved in cognitive function following treatment with Searsia chirindensis.
(2016)Febrile seizures are of growing concern in the health fraternity within the African continent. These seizures predominantly affect children between the ages of 3 months and 5 years of age. Stress during pregnancy may ... -
The efficacy of manual versus local vibratory massage in promoting recovery from post-exercise muscle damage - a systematic review.
(2016)Background. It is well established that unaccustomed activity/exercise with a large eccentric component causes the development of muscle damage which results in soreness and a decline in the functional capacity of muscle. ... -
Evaluation of the efficacy of maslinic acid on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats : effects on blood glucose and renal fluid and electrolyte handling.
(2014)Introduction Malaria remains a major socio-economic burden in Africa despite the numerous global efforts to control and manage the disease through prevention and drug intervention. Clinical studies have shown that malaria ... -
Effect of highly active antiretroviral therapy (HAART) on HIV-1 tat protein-induced neurotoxicity.
(2014)Background: HIV-1-trans-activating (Tat) protein has been associated with development of HIVassociated neurocognitive disorder (HAND). Previous studies have demonstrated that Tat protein causes neurotoxicity through an ... -
Contractile effects of Gunnera perpensa and Rhoicissus tridentata bioactive extracts in isolated rat uterine muscles.
(2014)Abstract available in PDF file. -
Exercise and type 2 diabetes mellitus : peripheral sensory neuropathy in humans and regulation of blood glucose control in rodents.
(2014)PART ONE A prospective cohort study was conducted on eight previously inactive diabetic volunteers (34 – 47 yr) with a mean pre-trial HbA1c of 7.45 (±1.34) %, who completed an 8-week endurance exercise intervention of ... -
The effects of oxidovanadium complexes on glucose metabolism in liver and skeletal muscle cell lines.
(2014)Abstract available in PDF file. -
Tat protein induced neurocognitive dysfunction.
(2013)Human immunodeficiency virus type 1 (HIV-1) is a major health threat in South Africa. Studies have shown that HIV affects the central nervous system (CNS), and can initiate a progressive neurodegenerative process culminating ... -
Evaluation of the efficacy of transdermal delivery of chloroquine on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats : effects on blood glucose and renal electrolyte handling.
(2013)Malaria remains a leading cause of morbidity and mortality in tropical regions of the world despite the numerous global efforts to control and manage the disease through prevention and drug intervention. An estimated 300–500 ... -
Evaluation of the efficacy of Syzygium aromaticum-derived Oleanolic acid on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats and effects on blood glucose and renal electrolyte handling.
(2014)Introduction Malaria continues to be one of the major causes of morbidity and mortality worldwide even though the disease is treatable. This is as a result of malaria parasites developing resistance to current antimalarial ... -
Evaluating a new drug to combat alzheimer's disease.
(2014)Alzheimer’s disease (AD), a progressive neurodegenerative disorder that affects mostly the limbic system and the neocortical areas of the brain, is the most prevalent form of dementia affecting the elderly population. ... -
The optimisation of a preeclampsia-like L-NAME rat model : a focus on utero-placental dysfunction.
(2014)Preeclampsia is a multi-system pregnancy syndrome characterized by the sudden onset of hypertension, escalated proteinuria and in some cases oedema usually after 20 weeks of gestation. Preeclampsia is further categorized ...
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