Physiology
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An investigation into the neurochemical and behavioural patterns of C57Bl6 mice exposed to "Sugars" and its constituents.
(2020)“Sugars” is an illicit drug cocktail that is a low-grade mixture of heroin and other opioids. The composition of this cocktail is highly varied as other ingredients are added during its manufacturing process to add bulk ... -
The effect of isolated and nanoencapsulated flavonoids from Eriocephalus africanus on apoptotic factors and microRNA expression in cancer.
(2020)Cancer continues to be a major health burden worldwide, with millions of new cases being diagnosed each year. Among women breast cancer remains a leading cause of cancer-related morbidity and mortality globally, despite ... -
Evaluation of the therapeutic properties of a Ruthenium(ll) uracil-derived diimine complex on selected complications associated with diet-induced pre-diabetes.
(2019)Pre-diabetes is a chronic metabolic condition where blood glucose levels are above the upper threshold considered normal but below the threshold for a diagnosis of diabetes. Pre-diabetes predisposes individuals to a high ... -
Evaluating the role of maternal separation stress on the development of autistic-like behaviour in Sprague-Dawley rats.
(2020)Autism Spectrum Disorders (ASD) are a category of neurodevelopmental disorders that have become more prevalent, causing much concern. Autistic individuals display symptoms ranging from repetitive behaviours to communication ... -
Evaluating immune activation and cellular determinants of thrombosis in pre-diabetes.
(2018)Introduction Platelet dysregulation in pre-diabetes plays a major role in the progression of prothrombotic and pro-inflammatory conditions. Cardiovascular disease (CVD), which may occur at the pre-diabetic stage, are a ... -
Investigating the effects of bredemolic acid on selected markers of some prediabetes-associated dysfunctions in diet-induced prediabetic rats.
(2019)Prediabetes is an abnormal glycaemic state between normoglycaemia and chronic hyperglycaemia which is currently prevalent in developing and developed countries due to increased consumption of high caloric diet coupled with ... -
Investigating the biomarker potential of exosomes in preeclampsia.
(2019)Preeclampsia is a hypertensive disorder of pregnancy and one of the leading causes of maternal and perinatal morbidity, affecting up to 7 -10% of pregnancies globally which results in 50 000-76 000 maternal deaths per year ... -
Effects of antipsychotic dose reduction on metabolic syndrome in patients with first episode psychosis treated with a long-acting injectable antipsychotic.
(2019)Background: The introduction of antipsychotics has been a significant milestone in the treatment of schizophrenia. However, these agents have several important side effects, such as metabolic syndrome. Options to curb these ... -
Effects of momordica balsamina on glucose handling in high fat high carbohydrate induced prediabetic rat model and glucose handling in C2C12 induced insulin resistant cell lines: effects on selected metabolic markers.
(2020)Increased consumption of fat and high carbohydrate coincided with increased prevalence in type 2 diabetes, a condition whose onset is always preceded by prediabetes. Prediabetes is best characterised by hyperglycaemia, ... -
The cytotoxic effects, anti-iflammatory, antioxidant, antibacterial, and antidiabetic properties of eight selected South African plants for medicinal purposes.
(2020)People from the Southern African region have been using the fauna and flora of the region in their homes for millennia to treat all sorts of ailments and complaints with great success. This knowledge transfer was done ... -
An evaluation of the chemical composition and the in vitro and in vivo antihypertensive activity of extracts of Tulbaghia acutiloba Harv. in an L-NAME induced hypertensive model.
(2019)The increasing prevalence of hypertension over the years has been identified as a major contributor to high morbidity and mortality, globally and locally, in Africa, posing a serious global health threat. The demand for ... -
The effects of prenatal stress on the preoptic nuclei of febrile seizure rat models.
(2019)Febrile seizures are a neurological abnormality that occurs after an underlying systemic infection, leading to fever and followed by convulsions due to neuronal hyper-excitability. Although regarded as benign, prenatal ... -
Effects of Momordica balsamina methanolic extract on cardiovascular and haematological function in streptozotocin-induced diabetic rats : effects on selected markers.
(2018)Background The hyperglycaemia-induced haemanetic changes reduces the oxygen-carrying capacity of erythrocytes, thus aggravating cardiovascular disorders in diabetic patients. The conventional therapies have been shown to ... -
Investigating changes to the insulin signalling pathway in a diet-induced pre-diabetic rat model: effects on selected markers.
(2019)No abstract available. -
Fungal endophytes: isolation, identification and assessment of bioactive potential of their natural products.
(2017)Fungal endophytes produce a broad variety of bioactive compounds with potential to address some of the unmet human needs. Medicinal plants have an important role to play in the search for new strains of endophytes ... -
A voice-centered relational analysis of the career development narratives of six Black African professionals in KwaZulu-Natal, South Africa.
(2018)Career Psychology and career education is not a new concept in the South African context, it is evident dating back as far as 1943. Literature shows that career guidance was first introduced in White schools and later ... -
HIV-1 transactivator of transcription (TAT) protein causes neurotoxicity via astrocyte activation.
(2015)HIV is most well-known for its negative effects on the immune system and the resulting development of AIDS, however it also has severe damaging effects on the central nervous system. Many infected individuals exhibit ... -
Prenatal stress and febrile seizures effects on the epigenetic mechanisms involved in cognitive function following treatment with Searsia chirindensis.
(2016)Febrile seizures are of growing concern in the health fraternity within the African continent. These seizures predominantly affect children between the ages of 3 months and 5 years of age. Stress during pregnancy may ... -
The efficacy of manual versus local vibratory massage in promoting recovery from post-exercise muscle damage - a systematic review.
(2016)Background. It is well established that unaccustomed activity/exercise with a large eccentric component causes the development of muscle damage which results in soreness and a decline in the functional capacity of muscle. ... -
Insulin resistance and salt sensitivity in the rat model of hypertension
(2002)Abstract available in PDF file.
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