Physiology
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T cell function and immune checkpoint inhibition in chronic lymphocytic leukaemia.
(2021)Background: The global burden of lymphoid malignancies gradually increased over the past decade, with chronic lymphocytic leukaemia (CLL) accounting for a quarter of the burden of all haematological malignancies. ... -
The effect of prenatal Mycobacterium tuberculosis infection on offspring neurodevelopment and autistic-like behaviours in a valproic acid mouse model of autism.
(2021)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted repetitive patterns, communication challenges and lack of social skills. ASD has no distinct biomarkers, with symptoms overlapping ... -
The acute effects of dioxidovanadium on blood glucose concentration and oxidative stress in the hippocampus of non-diabetic male Sprague Dawley rats and the chronic effects of dioxidovanadium on selected markers associated with hippocampal dysfunction in male streptozotocin-induced diabetic rats.
(2022)Diabetes mellitus is a disease associated with derangements in glucose metabolism and chronic hyperglycaemia. Chronic hyperglycaemia induces oxidative stress and inflammation that affect glucose sensitive hippocampal neurons ... -
Evaluation of the potential benefits of L-ergothioneine on selected complications associated with type-2 diabetes in a rat model.
(2021)Several pathogenic factors promote type-2 diabetic complications in patients, including cardiomyopathy, nephropathy, and non-alcoholic fatty liver disease (NAFLD). Specific nutraceuticals from food may act as a medicinal ... -
Investigating the effects of diet-induced pre-diabetes on calcium homeostasis in male Sprague Dawley rats.
(2022)Diabetes mellitus (DM) affects over 400 million people worldwide with 90-95% being type 2 diabetes mellitus (T2DM) in South Africa. T2DM is positively correlated with the chronic consumption of a high caloric diet, often ... -
The alteration of dopamine receptors in L-DOPA (L-3,4-dihydroxyphenylalanine) induced dyskinesias.
(2021)L-3,4-dihydroxyphenylalanine (L-DOPA) can ease symptoms of Parkinson’s disease (PD), butextended use of L-DOPA causes abnormal involuntary movements (AIMs) called L-DOPA induced dyskinesias (LIDs). The present study aims ... -
Role of neuroinflammation in an amyloid-beta model of Alzheimer’s disease and the identification of possible biomarker.
(2020)Introduction. Alzheimer's disease (AD) is the most common form of neurodegenerative disorder that results in dementia. It currently affects 75 million people worldwide and is predicted to affect as many as 135 million ... -
Impact of quercetin-3-0-rutinoside on biochemical and reproductive profile of rats prenatally exposed to high fat diet.
(2020)The increasing prevalence of infertility and obesity over the last few decades have become a major public health challenge among individuals within the reproductive age. Consumption of a high-fat diet (HFD) is a harbinger ... -
Biomarkers and histopathologic changes in rats with monocrotaline-induced pulmonary hypertension following administration of antiretroviral medications.
(2020)Pulmonary hypertension (PH) is a progressive life-threatening vasculopathy characterized by dysregulated pulmonary vascular remodelling that results in an increased pulmonary vascular resistance, right ventricular ... -
Investigating immune metabolism and exhaustion in Type 2 Diabetes.
(2020)Introduction In the era of rapid modernisation and urbanisation, the global incidence of non-communicable diseases such as type 2 diabetes (T2D) has significantly increased. This has been attributed to increased sedentary ... -
The determination of unilateral ratios (knee and shoulder muscle strength), of provincial cricketers.
(2002)Abstract available in PDF. -
The effect of infra-red laser therapy on fibroblast activity in cell culture.
(1997)Abstract available in PDF. -
The use of laser doppler fluxmetry in the pre-operative assessment of amputation wound healing in the dysvascular patient.
(1997)Abstract available in PDF. -
An investigation into the neurochemical and behavioural patterns of C57Bl6 mice exposed to "Sugars" and its constituents.
(2020)“Sugars” is an illicit drug cocktail that is a low-grade mixture of heroin and other opioids. The composition of this cocktail is highly varied as other ingredients are added during its manufacturing process to add bulk ... -
The effect of isolated and nanoencapsulated flavonoids from Eriocephalus africanus on apoptotic factors and microRNA expression in cancer.
(2020)Cancer continues to be a major health burden worldwide, with millions of new cases being diagnosed each year. Among women breast cancer remains a leading cause of cancer-related morbidity and mortality globally, despite ... -
Evaluation of the therapeutic properties of a Ruthenium(ll) uracil-derived diimine complex on selected complications associated with diet-induced pre-diabetes.
(2019)Pre-diabetes is a chronic metabolic condition where blood glucose levels are above the upper threshold considered normal but below the threshold for a diagnosis of diabetes. Pre-diabetes predisposes individuals to a high ... -
Evaluating the role of maternal separation stress on the development of autistic-like behaviour in Sprague-Dawley rats.
(2020)Autism Spectrum Disorders (ASD) are a category of neurodevelopmental disorders that have become more prevalent, causing much concern. Autistic individuals display symptoms ranging from repetitive behaviours to communication ... -
Evaluating immune activation and cellular determinants of thrombosis in pre-diabetes.
(2018)Introduction Platelet dysregulation in pre-diabetes plays a major role in the progression of prothrombotic and pro-inflammatory conditions. Cardiovascular disease (CVD), which may occur at the pre-diabetic stage, are a ...
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