Medical Biochemistry
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Betulinic acid enhances the antioxidant profile in a hyperglycaemic model.
(2019)Type 2 diabetes mellitus (T2DM) is a global pandemic, with prevalence rapidly rising in South Africa. T2DM is characterized by insulin resistance, leading to hyperglycaemia which induces oxidative stress (OS) and inflammation ... -
Fusaric acid-induced epigenetic modifications in vitro and in vivo: alternative mechanisms of hepatotoxicity.
(2019)The Fusarium-produced mycotoxin, Fusaric acid (FA), is a frequent contaminant of agricultural foods that exhibits toxicity in plants and animals with little information on its molecular and epigenetic mechanisms. Epigenetic ... -
Fumonisin B2 induces mitochondrial stress and mitophagy in Hek293 cells.
(2019)Food insecurity poses a significant socio-economic problem in third world economies, particularly in countries that rely heavily on maize and maize products. Ubiquitous soil fungi parasitize agricultural commodities and ... -
An in vitro and in vivo evaluation of the immuno and neurotoxicological effects of fusaric acid on altered protein kinase signalling cascades.
(2019)Mycotoxins are naturally occurring toxins produced by moulds which contaminate numerous crops and foodstuffs including cereals, nuts and fruits. When consumed, mycotoxins pose a serious threat to both human and animal ... -
Fumonisin B1-induced oxidative stress in human liver (HepG2) cells – an alternate mechanism of carcinogenesis.
(2017)Abstract available in pdf. -
An investigation of the anti-hyperglycaemic, biochemical and molecular effects of 4-hydroxyisoleucine and fenugreek seed extract in comparison to metformin in vitro and in vivo.
(2017)Type two diabetes mellitus (T2D) is a significant cause of premature death and disability, accompanied with negative socio-economic impacts. This metabolic disorder is characterized by hyperglycaemia and defective insulin ... -
A biochemical assessment of Ochratoxin A stress responses in vitro, with resveratrol as a possible therapeutic intervention.
(2017)Abstract available in PDF file. -
An investigation of stress-responses in pregnant women exposed to ambient air pollution in Durban, South Africa.
(2017)Living or working within an unhealthy environment is attributed to 12.6 million deaths worldwide and 2.2 million deaths in Africa. Ambient air pollution (AAP) exposure is amongst the major contributors of environmental and ... -
Temporal gene expression of Chlamydia trachomatis in keratinocytes at 37° versus 33°C.
(2017)Abstract available in PDF file. -
An investigation into the clinical outcomes of women with peripartum cardiomyopathy at Klerksdorp/Tshepong Hospital Complex.
(2015)Introduction: Peripartum Cardiomyopathy (PPCM) is defined on the basis of 4 criteria: The development of cardiac failure in the last month of pregnancy and up to 5 months after delivery; Absence of an identifiable ... -
Molecular and biochemical aspects of the kallikrein-kinin system in oesophageal carcinoma.
(1999)Abstract available in PDF file. -
Moringa oleifera crude aqueous leaf extract induces apoptosis in human hepatocellular carcinoma cells via the upregulation of NF-kB and IL-6/STAT3 pathway.
(2016)Abstract available in PDF file. -
Fusaric acid induces DNA damage and post-translational modification Of p53 in hepatocellular carcinoma (HepG2) cells.
(2016)Abstract available in PDF file. -
Quantification of circulating cell free fetal DNA and cell free total DNA in normal pregnancy and in pregnancy-related hypertension in Black South African Women.
(2016)Abstract available in PDF file. -
Atorvastatin induces apoptosis via the P13K/AKT signalling pathway in human hepatocellular carcinoma (HEPG2) cells.
(2016)Abstract available in PDF file. -
Fusaric acid dampens the Nrf2-mediated stress response in human embryonic kidney cells.
(2016)Abstract available in PDF file. -
HMG-CoA reductase inhibitor, atorvastatin induces apoptasis in human lung adenocarcinoma cell (A549).
(2015)Abstract available in PDF file. -
Moringa oleifera crude aqueous leaf extract induces apoptosis in human hepatocellular carcinoma cells via the upregulation of NF-kB and IL-6/STAT3 pathway.
(2016)Abstract available in PDF file. -
Fusaric acid induces oxidative stress and apoptosis in human oesophageal cancer cells.
(2016)Abstract available in PDF file.