Browsing Masters Degrees (Virology) by Title
Now showing items 21-33 of 33
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Innovative and affordable HIV-1 drug resistance testing for resource limited settings.
(2022)Background: HIV drug resistance (HIVDR) remains a major threat to achieving sustainable viral suppression on antiretroviral treatment (ART). Most countries including those in resource limited settings (RLS) have adopted ... -
Investigating the impact of HIV infection on ILC3s in human lymph nodes.
(2022)People living with HIV (PLWH) develop extensive fibrosis and collagen deposition throughout their lymphoid tissues not reversed by antiretroviral therapy (ART). Innate lymphoid cells (ILCs) play essential roles in tissue ... -
An investigation into the serological and molecular diagnosis of Jaagsiekte Sheep Retrovirus (JSRV)
(2005)The Jaagsiekte Sheep Retrovirus (JSRV), an exogenous type B/D-retrovirus with about 10-15 endogenous counterparts in all normal sheep genomes, causes Jaagsiekte (JS) or ovine pulmonary adenocarcinoma (OPA), a contagious ... -
An investigation of virologic failure and the spectrum of drug resistance mutations in a paediatric ART programme in rural KZN, SA.
(2014)Background Better understanding of drug resistance patterns in HIV-infected children on antiretroviral therapy (ART) is required to inform public health policies in high prevalence settings. The aim of this study was to ... -
Measuring HLA-B allele expression across differential cell types.
(2018)Background: The human leukocyte antigen (HLA) region has shown to have the strongest disease associations and recent studies have shown that expression levels of these HLA molecules play a major role in the clinical course ... -
Minority HIV-1 drug resistance mutations in patients failing highly active antiretroviral therapy (HAART).
(2014)Abstract not available. -
Molecular diagnosis and typing of HTLV-I in KwaZulu-Natal.
(1998)Two areas of the HTLV-I genome were targeted for an in-house molecular diagnostic test, namely the pol and env regions. The pol primers proved the most sensitive (100%)and specific (100%). Amplification using the env primer ... -
Molecular epidemiology of HIV-2 infection in KwaZulu-Natal Provnce, South Africa.
(2013)Infection with HIV-2 has important implications for the diagnosis, treatment and management of the infection. The objective of this study was to describe the seroprevalence and molecular epidemiology of HIV-2 in KwaZulu-Natal ... -
Nucleoside reverse transcriptase inhibitors-associated mutations in the RNase H region of HIV-1 isolates in South African adults and children failing highly active antiretroviral therapy.
(2012)Background: The South African national treatment program includes NRTIs in both first and second line highly active antiretroviral therapy regimens. Recently, mutations in the RNase H domain have been associated with ... -
Prevalence of minority HIV-1 drug resistant quasi-species in children patients at virologic failure in a rural KwaZulu-Natal cohort.
(2016)Abstract available in PDF file. -
The role of Nef-mediated SERINC5 down-regulation on HIV-1 disease progression.
(2021)HIV-1 Nef is a small accessory protein that plays a vital role in enhancing HIV-1 pathogenesis, evidenced by a strongly attenuated disease course following infection with a virus with gross Nef defects. Nef has multiple ... -
The role of the protease cleavage sites in viral fitness and drug resistance in HIV-1 subtype C.
(2010)There is an increasing number of patients failing second line highly active antiretroviral therapy (AZT, DDI and LPV/r) in South Africa, where HIV-1 subtype C predominates. Mutations at gag cleavage sites (CS) have ... -
Sequence analysis of an HIV-1 subtype C acutely infected cohort from Durban, South Africa.
(2018)The Human Immunodeficiency Virus is a global public health concern. The Joint United Nations Programme on HIV/AIDS estimated that 36.9 million people were infected with HIV globally at the end of 2017. Almost 20% of these ...