Browsing Masters Degrees (Virology) by Title
Now showing items 25-33 of 33
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Measuring HLA-B allele expression across differential cell types.
(2018)Background: The human leukocyte antigen (HLA) region has shown to have the strongest disease associations and recent studies have shown that expression levels of these HLA molecules play a major role in the clinical course ... -
Minority HIV-1 drug resistance mutations in patients failing highly active antiretroviral therapy (HAART).
(2014)Abstract not available. -
Molecular diagnosis and typing of HTLV-I in KwaZulu-Natal.
(1998)Two areas of the HTLV-I genome were targeted for an in-house molecular diagnostic test, namely the pol and env regions. The pol primers proved the most sensitive (100%)and specific (100%). Amplification using the env primer ... -
Molecular epidemiology of HIV-2 infection in KwaZulu-Natal Provnce, South Africa.
(2013)Infection with HIV-2 has important implications for the diagnosis, treatment and management of the infection. The objective of this study was to describe the seroprevalence and molecular epidemiology of HIV-2 in KwaZulu-Natal ... -
Nucleoside reverse transcriptase inhibitors-associated mutations in the RNase H region of HIV-1 isolates in South African adults and children failing highly active antiretroviral therapy.
(2012)Background: The South African national treatment program includes NRTIs in both first and second line highly active antiretroviral therapy regimens. Recently, mutations in the RNase H domain have been associated with ... -
Prevalence of minority HIV-1 drug resistant quasi-species in children patients at virologic failure in a rural KwaZulu-Natal cohort.
(2016)Abstract available in PDF file. -
The role of Nef-mediated SERINC5 down-regulation on HIV-1 disease progression.
(2021)HIV-1 Nef is a small accessory protein that plays a vital role in enhancing HIV-1 pathogenesis, evidenced by a strongly attenuated disease course following infection with a virus with gross Nef defects. Nef has multiple ... -
The role of the protease cleavage sites in viral fitness and drug resistance in HIV-1 subtype C.
(2010)There is an increasing number of patients failing second line highly active antiretroviral therapy (AZT, DDI and LPV/r) in South Africa, where HIV-1 subtype C predominates. Mutations at gag cleavage sites (CS) have ... -
Sequence analysis of an HIV-1 subtype C acutely infected cohort from Durban, South Africa.
(2018)The Human Immunodeficiency Virus is a global public health concern. The Joint United Nations Programme on HIV/AIDS estimated that 36.9 million people were infected with HIV globally at the end of 2017. Almost 20% of these ...