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Novel siRNA lipoplexes : their targeted and untargeted delivery to mammalian cells in culture.
The high gene knockdown specificity and efficiency of RNA interference (RNAi) provides a potentially viable avenue for the development of a new class of nucleic acid therapeutics for gene-based disease conditions. However, ...
Novel cationic lipoplexes : characterization in cell culture in vitro and in vivo.
Amongst the more promising non-viral DNA vehicles are liposomes, with those derived from cationic lipids showing significant potential, despite moderate transfection levels in vivo. This study has investigated the effect ...