Now showing items 1-10 of 11
Changes in endosome-lysosome pH accompanying pre-malignant transformation.
The mechanisms by which altered processing, distribution and secretion of proteolytic enzymes occur, facilitating degradation of the extracellular matrix in invasive and metastatic cells, are not fully understood. Studies ...
Recombinant expression of, and characterisation of antibodies against variable surface glycoproteins : LiTat 1.3 and LiTat 1.5 of Trypanosoma brucei gambiense.
Human African Trypanosomiasis (HAT), also known as sleeping sickness is one of the many life threatening tropical diseases posing a serious risk to livelihoods in Africa. The disease is restricted to the rural poor across ...
Characterisation of infectious bursal disease virus (IBDV) polyprotein processing.
Infectious bursal disease virus (IBDV) is a birnavirus that infects the B-cells in the bursa of Fabricius of young chickens, causing Gumboro disease. The IBDV 114 kDa polyprotein (NH2-pVP2-VP4-VP3-COOH) is thought to be ...
Evaluation of congopain and Oligopeptidase B as anti-disease vaccines for African Trypanosomiasis.
The protozoan parasite Trypanosoma congolense is one of the aetiological agents of African animal trypanosomiasis that is transmitted by the tsetse fly. The parasite causes nagana in animals and affects livestock throughout ...
Antibody-mediated inhibition of proteases of African trypanosomes.
The protozoan parasites Trypanosoma congolense and T. vivax cause trypanosomosis in cattle. The major lysosomal cysteine proteinase of T. congolense, congopain, may contribute to pathogenesis of the disease, and ...
Heterologous expression of invariant surface glycoproteins, ISG75 of Trypanosoma brucei brucei and T.b. gambiense, for antibody production and diagnosis of African Trypanosomiasis.
Accurate diagnosis of the presence of an infectious organism is very important for therapeutic interventions and consequently the recovery of the individual. There is a need for identifying new diagnostic antigens for the ...
Studies on the structural and biological functions of the Cu3 and Cu4 domains of IgM.
No abstract available.
The detection of two plasmodium falciparum metabolic enzymes using chicken antibodies.
Three protein targets are used in malaria rapid diagnostic tests (RDTs). These are Plasmodium falciparum histidine rich protein 2, Plasmodium lactate dehydrogenase and aldolase. A thrust of research in RDTs is to improve ...
Dye-protein interactions : protein staining and dye-IgY, dye-dextran-IgY complexes for antigen detection.
In order to develop a cheaper alternative to the conventional enzyme-linked immunosorbent assay system, application of dye molecules as labels in immunoassay was investigated in this study. This chromogenic dye-antibody ...
Coupling dyes to chicken IgY antibodies for the development of immunodiagnostic tests.
The aim of this study was to develop a highly simplified, sensitive and specific malarial diagnostic test at the lowest possible cost. Initial work and optimisation of procedures was achieved with chicken antibodies by ...