Now showing items 1-10 of 17
The impact of aromatic ring count on the bioavailability of chemical compounds.
Aromatic rings are a negative contributing factor in the bioavailability of chemical compounds in drug discovery. Due to the inevitable effect the aromatic rings possess on the bioavailability of chemical compounds, methods ...
Development of a novel biochemical assay for the identification of promiscuous compounds.
Promiscuous compounds, specifically aggregate-based inhibitors that result in false positives in biochemical activity assays present a serious and increasing interference to early-stage drug discovery processes. Although ...
Developing in vitro multi co-culture models and analysis tools for muscle regeneration.
Skeletal muscle regeneration represents a complex process mediated by non-myogenic cell types. These cells, such as macrophages and fibroblasts, display a range of interactions with muscle stem cells (myoblasts) during ...
Recombinant expression of plasmodium falciparum histidine rich protein-2 (PfHRP-2) and characterisation of chicken anti-PfHRP-2 antibodies.
The diagnosis of malaria using rapid diagnostic tests (RDTs) targets three Plasmodial proteins namely, Plasmodium falciparum histidine rich protein-2 (PfHRP-2); lactate dehydrogenase (LDH) and aldolase. Early diagnosis is ...
Screening for biosurfactant production amongst aerobic endospore forming bacteria isolated from Mfabeni peatland sediment core.
Abbstract available in pdf.
Recombinant expression, purification, analysis and immunization of mice with plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase (rPyGAPDH) and lactate dehydrogenase (rPyLDH) and evaluation of protection against P. berghei challenge.
The principal focus in malaria research is the development of an effective malaria vaccine which will help to prevent death and eliminate the disease. This study investigated two plasmodial glycolytic enzymes as possible ...
Expression and evaluation of a 297-amino acid fragment of the blood stage protein PfC0760c from Plasmodium falciparum.
Abstract available in pdf.
Quantification of time-dependent redox signalling in the Tpx1/Pap1 pathway in Schizosaccharomyces pombe.
Reactive oxygen species (ROS) can damage cellular components leading to cell death, but paradoxically, ROS also play essential roles in metabolism and signalling in eukaryotic cells. Dysregulation of this balance is ...