Now showing items 1-10 of 25
Molecular characterisation of metacaspase 5 and the production of oligopeptidase b-specific single chain variable fragment antibodies for potential animal African trypanosomosis chemotherapies and diagnostics.
African trypanosomosis (AT) is a major obstacle in the establishment of agriculture and economic sustainability in Africa. Animal AT is responsible for large numbers of livestock succumbing to the tsetse transmitted ...
Recombinant expression optimisation and characterisation of peptidases for diagnosis of animal African Trypanosomosis.
Abstract available in PDF file.
Genetic diversity of populations of a Southern African millipede, Bicoxidens flavicollis (Diplopoda, Spirostreptida, Spirostreptidae)
The African millipede genus Bicoxidens is endemic to Southern Africa, inhabiting a variety of regions ranging from woodlands to forests. Nine species are known within the genus but Bicoxidens flavicollis is the most dominant ...
An investigation into the analytical, cytotoxicity and immunotoxicity of mycotoxins found in commercially available pelleted pet foods in Durban, South Africa.
Introduction: Dry pelleted dog food in the South African market is available via supermarket, pet stores (standard brands - SB) and veterinary channels (premium brands-PB). Similarly, cat food were viewed in two market ...
Screening, purification and characterisation of anti-pseudomonas aeruginosa compounds produced by endophytic fungi from Kigelia Africana.
The emergence of new diseases and drug resistant pathogens coupled with the side effects presented by conventional or synthetic drug use calls for the discovery of new antibiotics and chemotherapeutics. Pseudomonas aeruginosa ...
Anti-c-myc cholesterol-based lipoplexes: development, characterisation and evaluation as Onconanotherapeutic agents in vitro.
Strategies aimed at inhibiting the expression of the c-myc oncogene could provide the basis for alternative cancer treatment. In this regard, silencing c-myc expression using small interfering RNA (siRNA) is an attractive ...
Investigating the quorum-sensing inhibitory and potential HIV activity of indigenous South African sponge-associated bacterial extracts.
With bacterial antimicrobial resistance on the rise, alternative therapeutic agents are being sought. One such alternative is the use of anti-virulence strategies such as quorum-sensing inhibition (QSI), which has been ...
Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
Emerging drug resistance hinders the efforts to control malaria and so novel antimalarial drugs are required. Copper is essential for the survival of plasmodial parasites but the proteins involved in copper homeostasis are ...
The evaluation of novel metal -based compounds as potential BACE1 ligands.
The proposed primary cause of Alzheimer’s disease (AD) is the cleavage of the Amyloid-β precursor protein by the β- Amyloid cleavage enzyme 1 (BACE1). As such it has been proposed that inhibiting this enzyme would help ...