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Type IV collagenase and cathepsins L and H : proteinases involved in tumour invasion.
The collagenolytic proteinases, type IV collagenase and cathepsins Land H, have been implicated in tumour invasion and metastasis, by virtue of their degradative action on the extracellular matrix barriers traversed by ...
Properties of Cathepsin L in relation to a role in invasive cancer.
Cathepsin L, which has been implicated in many tissue degradative pathologies by virtue of its ability to degrade extracellular matrix components, was isolated by a novel, scaled-up protein purification method and purified ...
Proteinases and extracellular matrix degradation in breast cancer.
A variety of proteases have been shown to promote the progression of cancer by virtue of their ability to degrade extracellular proteinaceous barriers, such as basement membrane and interstitial stroma. At the outset of ...