Masters Degrees (Pharmaceutical Sciences): Recent submissions
Now showing items 1-20 of 110
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Molecular modelling approaches in Parkinson’s disease: enhancing Domperidone oral availability through nanopolymers.
(2019)Parkinson’s disease is symbolized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies, and a decent response to levodopa. However, ... -
Price, availability and affordability of antineoplastic medicines in Harare’s public and private institutions: implications for access.
(2020)Background: Antineoplastic medicines are increasingly becoming more vital in many public health setups. There has been significant progress made in terms of newer molecules since the advent of chemotherapy. Despite the ... -
Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.
(2020)Objective Reporting of adverse drug reactions (ADRs) in Namibian public health facilities is routinely done through safety yellow forms which are forwarded to the Therapeutics Information and Pharmacovigilance Centre ... -
The use and safety of antibiotic therapy in pregnant women.
(2020)Background Antibiotic therapy in pregnant women has significantly increased in the effort to reduce maternal and neonatal deaths. However, antibiotic exposure may negatively affect the developing foetus. Information on ... -
Computationally aided direct electrophilic trifluoromethylation and trifluoromethylthiolation via sulfonimidamides.
(2020)Fluorination chemistry is of interest due to fluorine being recognized as a crucial element in pharmaceuticals, and agrochemicals, with 30% of new small molecule drugs incorporating fluorine. The trifluoromethylation and ... -
The safety profile of Vilazodone: a study on post-marketing surveillance.
(2020)Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of the drug. Being a relatively new drug, it is ... -
Molecular analysis of human immuno-deficiency virus-1 (South African subtype C) protease drug resistance mutations emerging on Darunavir therapy.
(2020)Human immunodeficiency virus as the causative agent of acquired immune deficiency syndrome remains a serious infectious disease and the leading cause of deaths worldwide. According to UNAIDS, approximately 37 million ... -
Comparison of the costs of treating prostate cancer with standard chemotherapy regimens versus targeted nuclear medicines.
(2020)Background: Healthcare costs for the treatment of mCRPC continue to rise year on year. However, with the advent of targeted Nuclear medicine and continued treatment with standard chemotherapy regimen for the treatment ... -
A comparison study between public and private healthcare sector medicine prices in South Africa.
(2020)Introduction The adoption of medicine pricing regulations was established to counter the on-going global struggle of high medicine prices. South Africa’s healthcare is divided into the private and public sector and each ... -
Annual costs incurred on managing adverse drug reactions attributable to fixed-dose combination Highly Active Anti-Retroviral Therapy (HAART) in an outpatient ARV clinic in Gauteng.
(2020)Objective The aim of the study is to identify adverse drug reactions attributable to tenofovir- and zidovudine-based fixed-dose combinations of highly active anti-retroviral therapy and, subsequently, to determine the ... -
Theoretical study on the esterification of methanol with acetic acid and acid halides.
(2015)Esters are a unique class of organic compounds whose production and reactivity are examined in chemical industries and research laboratories throughout the world on a daily basis. An ongoing advancement in esterification ... -
Matching a chelator (DOTA) with ions for radio-pharmaceutical applications using DFT study.
(2016)Organometallic chelators can be potentially used for radiometal-based pharmaceuticals. The bifunctional chelator, which is covalently bound to a lead compound, forms a stable chelator―ion complex to deliver an isotope, as ... -
The impact of the introduction of generics and generic references pricing and candesartan and rosuvastatin utilisation, price and expenditure in South Africa.
(2017)Rationale for the study The growth of pharmaceutical expenditure as a percentage of total health care expenditure has stagnated, both locally and globally, despite increasing consumption. Two factors that contributed ... -
Exploring trends in antibiotic use and resistance in a district, regional and tertiary hospital in the uMgungundlovu District.
(2017)Antibiotics play an important role in overcoming life-threatening bacterial infections. However, the increasing rate of antibiotic resistance is a serious threat to public health. Undoubtedly the indiscriminate use of ... -
Trend analysis of antibiotic resistance in KwaZulu-Natal : a retrospective study 2011- 2015.
(2017)Objective: Antimicrobial resistance is a global phenomenon which is limiting treatment options for common infections resulting in poor clinical outcomes, increased mortality and increased cost of healthcare. Antibiotic ... -
Experiences of Implanon NXT® users at public health facilities in South Africa.
(2018)Background and aim: Implanon NXT® was introduced in South Africa (SA) in the public health sector in February 2014. There exist concerns with premature Implanon NXT® user discontinuation in SA however, the true extent ... -
Comparison of adherence to treatment and effectiveness of fixed dose combination ARV drugs to multiple dose regimens in adult patients in public sector.
(2018)Background As antiretroviral medicines have become increasingly available and affordable for the treatment of HIV infected patients in South Africa, the adoption of a fixed dose combination (FDC) was implemented in 2013 ... -
Adenosine monophosphate-activated protein kinase as a potential target for synthetic chalco-naringenin analogs and putative therapeutic applications.
(2017)Introduction: Diabetes mellitus is a multifactorial chronic metabolic disorder that is characterized by defects in endogenous insulin secretion or action, or both, resulting in chronic hyperglycemia, a clinical hallmark ... -
New disulfide reducing reagent for solid phase peptide synthesis.
(2019)The special physical and chemical properties of sulfur atom make thiols and disulphide bonds of vital importance in many biological processes. For instance, it is well known, the role of cysteine residues in proteins, ... -
Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital.
(2016)Background and Aim Antibiotics are one of the most troublesome classes of drugs contributing to adverse drug reactions. These adverse drug reactions are generally under reported. This study aimed to evaluate the adverse ...